node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FTCD | GART | ENSOCUP00000020521 | ENSOCUP00000003344 | FTCD_C domain-containing protein. | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | 0.993 |
FTCD | MTHFD1 | ENSOCUP00000020521 | ENSOCUP00000010081 | FTCD_C domain-containing protein. | Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. | 0.989 |
FTCD | MTHFD1L | ENSOCUP00000020521 | ENSOCUP00000002415 | FTCD_C domain-containing protein. | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. | 0.990 |
FTCD | MTHFD2 | ENSOCUP00000020521 | ENSOCUP00000004510 | FTCD_C domain-containing protein. | Uncharacterized protein. | 0.975 |
FTCD | MTHFD2L | ENSOCUP00000020521 | ENSOCUP00000008312 | FTCD_C domain-containing protein. | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like. | 0.973 |
FTCD | MTHFR | ENSOCUP00000020521 | ENSOCUP00000006304 | FTCD_C domain-containing protein. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.751 |
FTCD | MTHFS | ENSOCUP00000020521 | ENSOCUP00000038203 | FTCD_C domain-containing protein. | 5-formyltetrahydrofolate cyclo-ligase; Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5- formyltetrahydrofolate (5-CHO-H(4)PteGlu) to yield 5,10- methenyltetrahydrofolate. It can also use 5-formyltetrahydropteroic acid (5-CHO-H(4)Pte) and 5-formyltetrahydropteroylhistidine (5-CHO- H(4)PteHis) as substrate; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.990 |
FTCD | MTR | ENSOCUP00000020521 | ENSOCUP00000008420 | FTCD_C domain-containing protein. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.941 |
FTCD | SHMT1 | ENSOCUP00000020521 | ENSOCUP00000017814 | FTCD_C domain-containing protein. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.946 |
FTCD | SHMT2 | ENSOCUP00000020521 | ENSOCUP00000019769 | FTCD_C domain-containing protein. | Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial tran [...] | 0.942 |
GART | FTCD | ENSOCUP00000003344 | ENSOCUP00000020521 | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | FTCD_C domain-containing protein. | 0.993 |
GART | MTHFD1 | ENSOCUP00000003344 | ENSOCUP00000010081 | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. | 0.999 |
GART | MTHFD1L | ENSOCUP00000003344 | ENSOCUP00000002415 | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. | 0.999 |
GART | MTHFD2 | ENSOCUP00000003344 | ENSOCUP00000004510 | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | Uncharacterized protein. | 0.999 |
GART | MTHFD2L | ENSOCUP00000003344 | ENSOCUP00000008312 | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like. | 0.999 |
GART | MTHFR | ENSOCUP00000003344 | ENSOCUP00000006304 | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.776 |
GART | MTHFS | ENSOCUP00000003344 | ENSOCUP00000038203 | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | 5-formyltetrahydrofolate cyclo-ligase; Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5- formyltetrahydrofolate (5-CHO-H(4)PteGlu) to yield 5,10- methenyltetrahydrofolate. It can also use 5-formyltetrahydropteroic acid (5-CHO-H(4)Pte) and 5-formyltetrahydropteroylhistidine (5-CHO- H(4)PteHis) as substrate; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.967 |
GART | MTR | ENSOCUP00000003344 | ENSOCUP00000008420 | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.978 |
GART | SHMT1 | ENSOCUP00000003344 | ENSOCUP00000017814 | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.999 |
GART | SHMT2 | ENSOCUP00000003344 | ENSOCUP00000019769 | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial tran [...] | 0.999 |