node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APP | PICALM | ENSOCUP00000009130 | ENSOCUP00000022173 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Phosphatidylinositol binding clathrin assembly protein. | 0.656 |
APP | SORL1 | ENSOCUP00000009130 | ENSOCUP00000009783 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Sortilin-related receptor; Sorting receptor that directs several proteins to their correct location within the cell. Along with AP-1 complex, involved Golgi apparatus - endosome sorting. Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated. May also sort newly produced amyloid-beta peptides to lysosomes for catabolism. Does not affect APP trafficking from the endoplasmic r [...] | 0.996 |
APP | VPS35 | ENSOCUP00000009130 | ENSOCUP00000009037 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. | 0.527 |
CLTA | CLTB | ENSOCUP00000000009 | ENSOCUP00000012745 | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. | 0.971 |
CLTA | CLTC | ENSOCUP00000000009 | ENSOCUP00000042961 | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. | Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. | 0.999 |
CLTA | DNAJC6 | ENSOCUP00000000009 | ENSOCUP00000008633 | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. | DnaJ heat shock protein family (Hsp40) member C6. | 0.922 |
CLTA | GAK | ENSOCUP00000000009 | ENSOCUP00000002563 | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. | Cyclin G associated kinase. | 0.997 |
CLTA | GGA2 | ENSOCUP00000000009 | ENSOCUP00000007283 | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. | Golgi associated, gamma adaptin ear containing, ARF binding protein 2. | 0.447 |
CLTA | IGF2R | ENSOCUP00000000009 | ENSOCUP00000038815 | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. | Insulin like growth factor 2 receptor. | 0.544 |
CLTA | PICALM | ENSOCUP00000000009 | ENSOCUP00000022173 | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. | Phosphatidylinositol binding clathrin assembly protein. | 0.804 |
CLTA | SORL1 | ENSOCUP00000000009 | ENSOCUP00000009783 | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. | Sortilin-related receptor; Sorting receptor that directs several proteins to their correct location within the cell. Along with AP-1 complex, involved Golgi apparatus - endosome sorting. Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated. May also sort newly produced amyloid-beta peptides to lysosomes for catabolism. Does not affect APP trafficking from the endoplasmic r [...] | 0.954 |
CLTB | CLTA | ENSOCUP00000012745 | ENSOCUP00000000009 | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. | 0.971 |
CLTB | CLTC | ENSOCUP00000012745 | ENSOCUP00000042961 | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. | Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. | 0.999 |
CLTB | DNAJC6 | ENSOCUP00000012745 | ENSOCUP00000008633 | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. | DnaJ heat shock protein family (Hsp40) member C6. | 0.921 |
CLTB | GAK | ENSOCUP00000012745 | ENSOCUP00000002563 | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. | Cyclin G associated kinase. | 0.997 |
CLTB | GGA2 | ENSOCUP00000012745 | ENSOCUP00000007283 | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. | Golgi associated, gamma adaptin ear containing, ARF binding protein 2. | 0.554 |
CLTB | IGF2R | ENSOCUP00000012745 | ENSOCUP00000038815 | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. | Insulin like growth factor 2 receptor. | 0.554 |
CLTB | PICALM | ENSOCUP00000012745 | ENSOCUP00000022173 | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. | Phosphatidylinositol binding clathrin assembly protein. | 0.782 |
CLTB | SORL1 | ENSOCUP00000012745 | ENSOCUP00000009783 | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. | Sortilin-related receptor; Sorting receptor that directs several proteins to their correct location within the cell. Along with AP-1 complex, involved Golgi apparatus - endosome sorting. Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated. May also sort newly produced amyloid-beta peptides to lysosomes for catabolism. Does not affect APP trafficking from the endoplasmic r [...] | 0.950 |
CLTC | CLTA | ENSOCUP00000042961 | ENSOCUP00000000009 | Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. | 0.999 |