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NR3C1 protein (Oryctolagus cuniculus) - STRING interaction network
"NR3C1" - Glucocorticoid receptor in Oryctolagus cuniculus
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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NR3C1Glucocorticoid receptor ; Receptor for glucocorticoids (GC). Has a dual mode of action- as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5’ UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DC [...] (773 aa)    
Predicted Functional Partners:
NCOR1
Uncharacterized protein (2469 aa)
       
  0.982
NCOA1
Uncharacterized protein (1440 aa)
       
  0.968
OGT
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit ; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta- linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Involved in insulin resis [...] (1046 aa)
       
    0.941
NCOR2
Uncharacterized protein (713 aa)
       
  0.931
NCOA2
Uncharacterized protein (1466 aa)
       
  0.866
C-JUN
C-jun transcription factor (317 aa)
       
  0.863
NCOA3
Uncharacterized protein (1369 aa)
       
  0.842
ARNTL
Uncharacterized protein (632 aa)
       
  0.839
ENSOCUG00000017566
Uncharacterized protein (703 aa)
       
  0.833
ARNTL2
Uncharacterized protein (474 aa)
       
  0.833
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lagomorpha, Leporidae, Lepus cuniculus, New Zealand rabbit, O. cuniculus, Oryctolagus, Oryctolagus cuniculus, domestic rabbit, rabbit, rabbits, rabbits & hares, rabbits and hares
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