node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FKBP4 | FKBP5 | ENSOCUP00000048194 | ENSOCUP00000046356 | Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed; Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May [...] | Peptidylprolyl isomerase. | 0.953 |
FKBP4 | NR3C1 | ENSOCUP00000048194 | ENSOCUP00000046838 | Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed; Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May [...] | Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...] | 0.952 |
FKBP4 | NR3C2 | ENSOCUP00000048194 | ENSOCUP00000002724 | Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed; Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May [...] | Nuclear receptor subfamily 3 group C member 2. | 0.890 |
FKBP4 | PTGES3 | ENSOCUP00000048194 | ENSOCUP00000029851 | Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed; Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May [...] | Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway. | 0.916 |
FKBP4 | STIP1 | ENSOCUP00000048194 | ENSOCUP00000029749 | Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed; Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May [...] | Stress induced phosphoprotein 1. | 0.847 |
FKBP5 | FKBP4 | ENSOCUP00000046356 | ENSOCUP00000048194 | Peptidylprolyl isomerase. | Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed; Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May [...] | 0.953 |
FKBP5 | NR3C1 | ENSOCUP00000046356 | ENSOCUP00000046838 | Peptidylprolyl isomerase. | Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...] | 0.966 |
FKBP5 | NR3C2 | ENSOCUP00000046356 | ENSOCUP00000002724 | Peptidylprolyl isomerase. | Nuclear receptor subfamily 3 group C member 2. | 0.832 |
FKBP5 | PTGES3 | ENSOCUP00000046356 | ENSOCUP00000029851 | Peptidylprolyl isomerase. | Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway. | 0.957 |
FKBP5 | STIP1 | ENSOCUP00000046356 | ENSOCUP00000029749 | Peptidylprolyl isomerase. | Stress induced phosphoprotein 1. | 0.810 |
NCOA1 | NCOA2 | ENSOCUP00000013252 | ENSOCUP00000005169 | Nuclear receptor coactivator. | Nuclear receptor coactivator. | 0.995 |
NCOA1 | NCOR1 | ENSOCUP00000013252 | ENSOCUP00000009022 | Nuclear receptor coactivator. | Nuclear receptor corepressor 1. | 0.756 |
NCOA1 | NR3C1 | ENSOCUP00000013252 | ENSOCUP00000046838 | Nuclear receptor coactivator. | Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...] | 0.927 |
NCOA1 | NR3C2 | ENSOCUP00000013252 | ENSOCUP00000002724 | Nuclear receptor coactivator. | Nuclear receptor subfamily 3 group C member 2. | 0.864 |
NCOA1 | PPARGC1A | ENSOCUP00000013252 | ENSOCUP00000034883 | Nuclear receptor coactivator. | PPARG coactivator 1 alpha. | 0.677 |
NCOA2 | NCOA1 | ENSOCUP00000005169 | ENSOCUP00000013252 | Nuclear receptor coactivator. | Nuclear receptor coactivator. | 0.995 |
NCOA2 | NCOR1 | ENSOCUP00000005169 | ENSOCUP00000009022 | Nuclear receptor coactivator. | Nuclear receptor corepressor 1. | 0.708 |
NCOA2 | NR3C1 | ENSOCUP00000005169 | ENSOCUP00000046838 | Nuclear receptor coactivator. | Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...] | 0.957 |
NCOA2 | NR3C2 | ENSOCUP00000005169 | ENSOCUP00000002724 | Nuclear receptor coactivator. | Nuclear receptor subfamily 3 group C member 2. | 0.625 |
NCOA2 | PPARGC1A | ENSOCUP00000005169 | ENSOCUP00000034883 | Nuclear receptor coactivator. | PPARG coactivator 1 alpha. | 0.417 |