node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FAM180B | FHL1 | ENSOCUP00000005500 | ENSOCUP00000039818 | Family with sequence similarity 180 member B. | Four and a half LIM domains 1. | 0.438 |
FAM180B | PPP1R1A | ENSOCUP00000005500 | ENSOCUP00000039736 | Family with sequence similarity 180 member B. | Protein phosphatase 1 regulatory subunit 1A; Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. | 0.466 |
FAM49A | LRATD1 | ENSOCUP00000006812 | ENSOCUP00000001969 | Family with sequence similarity 49 member A. | LRAT domain containing 1. | 0.698 |
FAM49A | PPP1R1A | ENSOCUP00000006812 | ENSOCUP00000039736 | Family with sequence similarity 49 member A. | Protein phosphatase 1 regulatory subunit 1A; Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. | 0.562 |
FHL1 | FAM180B | ENSOCUP00000039818 | ENSOCUP00000005500 | Four and a half LIM domains 1. | Family with sequence similarity 180 member B. | 0.438 |
FHL1 | PPP1R1A | ENSOCUP00000039818 | ENSOCUP00000039736 | Four and a half LIM domains 1. | Protein phosphatase 1 regulatory subunit 1A; Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. | 0.459 |
FXYD1 | PPP1R1A | ENSOCUP00000022422 | ENSOCUP00000039736 | Phospholemman; Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. Belongs to the FXYD family. | Protein phosphatase 1 regulatory subunit 1A; Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. | 0.425 |
FXYD1 | RYR2 | ENSOCUP00000022422 | ENSOCUP00000002126 | Phospholemman; Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. Belongs to the FXYD family. | Ryanodine receptor 2; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. Required for cellular calcium ion homeostasis. Required for embryonic heart development (By similarity). The calcium channel activity is modulated by formation of heterotetramers with RYR3; Belongs to t [...] | 0.540 |
LRATD1 | FAM49A | ENSOCUP00000001969 | ENSOCUP00000006812 | LRAT domain containing 1. | Family with sequence similarity 49 member A. | 0.698 |
LRATD1 | PPP1R1A | ENSOCUP00000001969 | ENSOCUP00000039736 | LRAT domain containing 1. | Protein phosphatase 1 regulatory subunit 1A; Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. | 0.579 |
NAP1L2 | NAP1L3 | ENSOCUP00000025338 | ENSOCUP00000025415 | Nucleosome assembly protein 1 like 2; Belongs to the nucleosome assembly protein (NAP) family. | Nucleosome assembly protein 1 like 3; Belongs to the nucleosome assembly protein (NAP) family. | 0.481 |
NAP1L2 | PPP1R1A | ENSOCUP00000025338 | ENSOCUP00000039736 | Nucleosome assembly protein 1 like 2; Belongs to the nucleosome assembly protein (NAP) family. | Protein phosphatase 1 regulatory subunit 1A; Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. | 0.585 |
NAP1L3 | NAP1L2 | ENSOCUP00000025415 | ENSOCUP00000025338 | Nucleosome assembly protein 1 like 3; Belongs to the nucleosome assembly protein (NAP) family. | Nucleosome assembly protein 1 like 2; Belongs to the nucleosome assembly protein (NAP) family. | 0.481 |
NAP1L3 | PPP1R1A | ENSOCUP00000025415 | ENSOCUP00000039736 | Nucleosome assembly protein 1 like 3; Belongs to the nucleosome assembly protein (NAP) family. | Protein phosphatase 1 regulatory subunit 1A; Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. | 0.468 |
PPP1R1A | FAM180B | ENSOCUP00000039736 | ENSOCUP00000005500 | Protein phosphatase 1 regulatory subunit 1A; Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. | Family with sequence similarity 180 member B. | 0.466 |
PPP1R1A | FAM49A | ENSOCUP00000039736 | ENSOCUP00000006812 | Protein phosphatase 1 regulatory subunit 1A; Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. | Family with sequence similarity 49 member A. | 0.562 |
PPP1R1A | FHL1 | ENSOCUP00000039736 | ENSOCUP00000039818 | Protein phosphatase 1 regulatory subunit 1A; Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. | Four and a half LIM domains 1. | 0.459 |
PPP1R1A | FXYD1 | ENSOCUP00000039736 | ENSOCUP00000022422 | Protein phosphatase 1 regulatory subunit 1A; Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. | Phospholemman; Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. Belongs to the FXYD family. | 0.425 |
PPP1R1A | LRATD1 | ENSOCUP00000039736 | ENSOCUP00000001969 | Protein phosphatase 1 regulatory subunit 1A; Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. | LRAT domain containing 1. | 0.579 |
PPP1R1A | NAP1L2 | ENSOCUP00000039736 | ENSOCUP00000025338 | Protein phosphatase 1 regulatory subunit 1A; Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. | Nucleosome assembly protein 1 like 2; Belongs to the nucleosome assembly protein (NAP) family. | 0.585 |