STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
H1-4Histone H1.4; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). (221 aa)    
Predicted Functional Partners:
G1TUT9_RABIT
S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family.
   
 
 0.718
LOC100008822
Uncharacterized protein.
    
 
 0.707
CHMP4A
Charged multivesicular body protein 4A.
      
 0.649
CDK2
Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.
   
 0.624
G1TTA9_RABIT
40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.
    
 
 0.589
G1TVC6_RABIT
40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.
    
 
 0.589
G1SGC2_RABIT
Histone H2A; Belongs to the histone H2A family.
   
 0.567
USP47
Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family.
      
 0.563
LOC100340438
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
   
 0.551
ENSOCUP00000032761
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
   
 0.551
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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