node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCK | EDN1 | ENSOCUP00000013458 | ENSOCUP00000011526 | Gastrin domain-containing protein. | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | 0.432 |
CCK | GHRL | ENSOCUP00000013458 | ENSOCUP00000029787 | Gastrin domain-containing protein. | Uncharacterized protein. | 0.930 |
CCK | LOC100345534 | ENSOCUP00000013458 | ENSOCUP00000023317 | Gastrin domain-containing protein. | Gastrin domain-containing protein. | 0.901 |
CCK | MLNR | ENSOCUP00000013458 | ENSOCUP00000012668 | Gastrin domain-containing protein. | Motilin receptor; Belongs to the G-protein coupled receptor 1 family. | 0.684 |
CCK | NMU | ENSOCUP00000013458 | ENSOCUP00000014722 | Gastrin domain-containing protein. | Neuromedin-U-25; Stimulates uterine smooth muscle contraction and causes selective vasoconstriction; Belongs to the NmU family. | 0.528 |
CCK | NTS | ENSOCUP00000013458 | ENSOCUP00000008901 | Gastrin domain-containing protein. | Neurotensin. | 0.918 |
CCK | PPY | ENSOCUP00000013458 | ENSOCUP00000025326 | Gastrin domain-containing protein. | Pancreatic hormone; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions; Belongs to the NPY family. | 0.765 |
EDN1 | CCK | ENSOCUP00000011526 | ENSOCUP00000013458 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Gastrin domain-containing protein. | 0.432 |
EDN1 | EDN3 | ENSOCUP00000011526 | ENSOCUP00000046269 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | 0.965 |
EDN1 | GHRL | ENSOCUP00000011526 | ENSOCUP00000029787 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Uncharacterized protein. | 0.467 |
EDN1 | LOC100345534 | ENSOCUP00000011526 | ENSOCUP00000023317 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Gastrin domain-containing protein. | 0.427 |
EDN1 | MLNR | ENSOCUP00000011526 | ENSOCUP00000012668 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Motilin receptor; Belongs to the G-protein coupled receptor 1 family. | 0.510 |
EDN1 | NMU | ENSOCUP00000011526 | ENSOCUP00000014722 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Neuromedin-U-25; Stimulates uterine smooth muscle contraction and causes selective vasoconstriction; Belongs to the NmU family. | 0.457 |
EDN1 | NTS | ENSOCUP00000011526 | ENSOCUP00000008901 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Neurotensin. | 0.571 |
EDN3 | EDN1 | ENSOCUP00000046269 | ENSOCUP00000011526 | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | 0.965 |
EDN3 | MLNR | ENSOCUP00000046269 | ENSOCUP00000012668 | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | Motilin receptor; Belongs to the G-protein coupled receptor 1 family. | 0.506 |
EDN3 | NMU | ENSOCUP00000046269 | ENSOCUP00000014722 | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | Neuromedin-U-25; Stimulates uterine smooth muscle contraction and causes selective vasoconstriction; Belongs to the NmU family. | 0.440 |
EDN3 | NTS | ENSOCUP00000046269 | ENSOCUP00000008901 | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | Neurotensin. | 0.441 |
GHRL | CCK | ENSOCUP00000029787 | ENSOCUP00000013458 | Uncharacterized protein. | Gastrin domain-containing protein. | 0.930 |
GHRL | EDN1 | ENSOCUP00000029787 | ENSOCUP00000011526 | Uncharacterized protein. | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | 0.467 |