node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AARS1 | KARS1 | ENSOCUP00000007663 | ENSOCUP00000029499 | Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. | Lysine--tRNA ligase. | 0.909 |
AARS1 | LARS1 | ENSOCUP00000007663 | ENSOCUP00000029971 | Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. | Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.885 |
AARS1 | LARS2 | ENSOCUP00000007663 | ENSOCUP00000030288 | Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. | Leucyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.900 |
AARS1 | MARS1 | ENSOCUP00000007663 | ENSOCUP00000049774 | Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. | Methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.867 |
AARS1 | QARS1 | ENSOCUP00000007663 | ENSOCUP00000004408 | Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. | Glutaminyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.888 |
AARS1 | SARS1 | ENSOCUP00000007663 | ENSOCUP00000007455 | Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. | Serine--tRNA ligase, cytoplasmic; Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16 [...] | 0.833 |
AARS1 | WARS1 | ENSOCUP00000007663 | ENSOCUP00000047050 | Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. | Tryptophan--tRNA ligase, cytoplasmic; T1-TrpRS has aminoacylation activity while T2-TrpRS lacks it. T1-TrpRS and T2-TrpRS possess angiostatic activity. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (By similarity). | 0.869 |
AARS1 | WARS2 | ENSOCUP00000007663 | ENSOCUP00000010615 | Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. | Tryptophanyl tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.804 |
AARS1 | YARS1 | ENSOCUP00000007663 | ENSOCUP00000008622 | Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. | Tyrosine--tRNA ligase. | 0.983 |
AARS1 | YARS2 | ENSOCUP00000007663 | ENSOCUP00000000022 | Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. | Tyrosine--tRNA ligase. | 0.898 |
KARS1 | AARS1 | ENSOCUP00000029499 | ENSOCUP00000007663 | Lysine--tRNA ligase. | Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.909 |
KARS1 | LARS1 | ENSOCUP00000029499 | ENSOCUP00000029971 | Lysine--tRNA ligase. | Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.983 |
KARS1 | LARS2 | ENSOCUP00000029499 | ENSOCUP00000030288 | Lysine--tRNA ligase. | Leucyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.975 |
KARS1 | MARS1 | ENSOCUP00000029499 | ENSOCUP00000049774 | Lysine--tRNA ligase. | Methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.999 |
KARS1 | QARS1 | ENSOCUP00000029499 | ENSOCUP00000004408 | Lysine--tRNA ligase. | Glutaminyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.984 |
KARS1 | SARS1 | ENSOCUP00000029499 | ENSOCUP00000007455 | Lysine--tRNA ligase. | Serine--tRNA ligase, cytoplasmic; Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16 [...] | 0.809 |
KARS1 | WARS1 | ENSOCUP00000029499 | ENSOCUP00000047050 | Lysine--tRNA ligase. | Tryptophan--tRNA ligase, cytoplasmic; T1-TrpRS has aminoacylation activity while T2-TrpRS lacks it. T1-TrpRS and T2-TrpRS possess angiostatic activity. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (By similarity). | 0.888 |
KARS1 | WARS2 | ENSOCUP00000029499 | ENSOCUP00000010615 | Lysine--tRNA ligase. | Tryptophanyl tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.884 |
KARS1 | YARS1 | ENSOCUP00000029499 | ENSOCUP00000008622 | Lysine--tRNA ligase. | Tyrosine--tRNA ligase. | 0.989 |
KARS1 | YARS2 | ENSOCUP00000029499 | ENSOCUP00000000022 | Lysine--tRNA ligase. | Tyrosine--tRNA ligase. | 0.923 |