node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |

AKR1D1 | CYP17A1 | ENSOCUP00000014594 | ENSOCUP00000015281 | 3-oxo-5-beta-steroid 4-dehydrogenase; Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates; Belongs to the aldo/keto reductase family | Cytochrome P450, family 17, subfamily A, polypeptide 1 | 0.913 |

AKR1D1 | CYP19A1 | ENSOCUP00000014594 | ENSOCUP00000010591 | 3-oxo-5-beta-steroid 4-dehydrogenase; Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates; Belongs to the aldo/keto reductase family | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens | 0.911 |

AKR1D1 | CYP8B1 | ENSOCUP00000014594 | ENSOCUP00000023170 | 3-oxo-5-beta-steroid 4-dehydrogenase; Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates; Belongs to the aldo/keto reductase family | 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; Involved in bile acid synthesis and is responsible for the conversion of 7-alpha-hydroxy-4-cholesten-3-one into 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha-hydroxylated C27 steroids; Belongs to the cytochrome P450 family | 0.961 |

AKR1D1 | HSD11B1 | ENSOCUP00000014594 | ENSOCUP00000003489 | 3-oxo-5-beta-steroid 4-dehydrogenase; Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates; Belongs to the aldo/keto reductase family | Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone | 0.922 |

AKR1D1 | HSD11B2 | ENSOCUP00000014594 | ENSOCUP00000010179 | 3-oxo-5-beta-steroid 4-dehydrogenase; Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates; Belongs to the aldo/keto reductase family | Corticosteroid 11-beta-dehydrogenase isozyme 2; Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids | 0.915 |

AKR1D1 | HSD17B2 | ENSOCUP00000014594 | ENSOCUP00000014316 | 3-oxo-5-beta-steroid 4-dehydrogenase; Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates; Belongs to the aldo/keto reductase family | Hydroxysteroid (17-beta) dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family | 0.913 |

AKR1D1 | HSD17B3 | ENSOCUP00000014594 | ENSOCUP00000007373 | 3-oxo-5-beta-steroid 4-dehydrogenase; Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates; Belongs to the aldo/keto reductase family | Hydroxysteroid (17-beta) dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family | 0.915 |

AKR1D1 | HSD3B7 | ENSOCUP00000014594 | ENSOCUP00000013726 | 3-oxo-5-beta-steroid 4-dehydrogenase; Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates; Belongs to the aldo/keto reductase family | Uncharacterized protein; Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | 0.974 |

AKR1D1 | SRD5A1 | ENSOCUP00000014594 | ENSOCUP00000014623 | 3-oxo-5-beta-steroid 4-dehydrogenase; Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates; Belongs to the aldo/keto reductase family | Steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | 0.949 |

AKR1D1 | SRD5A2 | ENSOCUP00000014594 | ENSOCUP00000001070 | 3-oxo-5-beta-steroid 4-dehydrogenase; Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates; Belongs to the aldo/keto reductase family | Steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) | 0.962 |

CYP17A1 | AKR1D1 | ENSOCUP00000015281 | ENSOCUP00000014594 | Cytochrome P450, family 17, subfamily A, polypeptide 1 | 3-oxo-5-beta-steroid 4-dehydrogenase; Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates; Belongs to the aldo/keto reductase family | 0.913 |

CYP17A1 | CYP19A1 | ENSOCUP00000015281 | ENSOCUP00000010591 | Cytochrome P450, family 17, subfamily A, polypeptide 1 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens | 0.949 |

CYP17A1 | HSD11B1 | ENSOCUP00000015281 | ENSOCUP00000003489 | Cytochrome P450, family 17, subfamily A, polypeptide 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone | 0.527 |

CYP17A1 | HSD11B2 | ENSOCUP00000015281 | ENSOCUP00000010179 | Cytochrome P450, family 17, subfamily A, polypeptide 1 | Corticosteroid 11-beta-dehydrogenase isozyme 2; Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids | 0.496 |

CYP17A1 | HSD17B2 | ENSOCUP00000015281 | ENSOCUP00000014316 | Cytochrome P450, family 17, subfamily A, polypeptide 1 | Hydroxysteroid (17-beta) dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family | 0.962 |

CYP17A1 | HSD17B3 | ENSOCUP00000015281 | ENSOCUP00000007373 | Cytochrome P450, family 17, subfamily A, polypeptide 1 | Hydroxysteroid (17-beta) dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family | 0.983 |

CYP17A1 | SRD5A1 | ENSOCUP00000015281 | ENSOCUP00000014623 | Cytochrome P450, family 17, subfamily A, polypeptide 1 | Steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | 0.976 |

CYP17A1 | SRD5A2 | ENSOCUP00000015281 | ENSOCUP00000001070 | Cytochrome P450, family 17, subfamily A, polypeptide 1 | Steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) | 0.964 |

CYP19A1 | AKR1D1 | ENSOCUP00000010591 | ENSOCUP00000014594 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens | 3-oxo-5-beta-steroid 4-dehydrogenase; Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates; Belongs to the aldo/keto reductase family | 0.911 |

CYP19A1 | CYP17A1 | ENSOCUP00000010591 | ENSOCUP00000015281 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens | Cytochrome P450, family 17, subfamily A, polypeptide 1 | 0.949 |