node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKR1D1 | CYP11B2 | ENSOCUP00000014594 | ENSOCUP00000012891 | Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one); Belongs to the aldo/keto reductase family. | Uncharacterized protein; Belongs to the cytochrome P450 family. | 0.922 |
AKR1D1 | CYP17A1 | ENSOCUP00000014594 | ENSOCUP00000015281 | Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one); Belongs to the aldo/keto reductase family. | Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.922 |
AKR1D1 | CYP19A1 | ENSOCUP00000014594 | ENSOCUP00000010591 | Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one); Belongs to the aldo/keto reductase family. | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | 0.913 |
AKR1D1 | CYP21A2 | ENSOCUP00000014594 | ENSOCUP00000006096 | Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one); Belongs to the aldo/keto reductase family. | Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family. | 0.918 |
AKR1D1 | HSD11B2 | ENSOCUP00000014594 | ENSOCUP00000037332 | Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one); Belongs to the aldo/keto reductase family. | Corticosteroid 11-beta-dehydrogenase isozyme 2; Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. | 0.933 |
AKR1D1 | HSD17B8 | ENSOCUP00000014594 | ENSOCUP00000017884 | Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one); Belongs to the aldo/keto reductase family. | Hydroxysteroid 17-beta dehydrogenase 8. | 0.918 |
AKR1D1 | HSD3B7 | ENSOCUP00000014594 | ENSOCUP00000034044 | Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one); Belongs to the aldo/keto reductase family. | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; Belongs to the 3-beta-HSD family. | 0.982 |
AKR1D1 | LOC100346986 | ENSOCUP00000014594 | ENSOCUP00000034335 | Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one); Belongs to the aldo/keto reductase family. | 3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. | 0.971 |
AKR1D1 | SRD5A1 | ENSOCUP00000014594 | ENSOCUP00000014623 | Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one); Belongs to the aldo/keto reductase family. | 3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. | 0.966 |
AKR1D1 | SRD5A2 | ENSOCUP00000014594 | ENSOCUP00000001070 | Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one); Belongs to the aldo/keto reductase family. | 3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. | 0.966 |
CYP11B2 | AKR1D1 | ENSOCUP00000012891 | ENSOCUP00000014594 | Uncharacterized protein; Belongs to the cytochrome P450 family. | Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one); Belongs to the aldo/keto reductase family. | 0.922 |
CYP11B2 | CYP17A1 | ENSOCUP00000012891 | ENSOCUP00000015281 | Uncharacterized protein; Belongs to the cytochrome P450 family. | Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.959 |
CYP11B2 | CYP19A1 | ENSOCUP00000012891 | ENSOCUP00000010591 | Uncharacterized protein; Belongs to the cytochrome P450 family. | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | 0.942 |
CYP11B2 | CYP21A2 | ENSOCUP00000012891 | ENSOCUP00000006096 | Uncharacterized protein; Belongs to the cytochrome P450 family. | Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family. | 0.961 |
CYP11B2 | HSD11B2 | ENSOCUP00000012891 | ENSOCUP00000037332 | Uncharacterized protein; Belongs to the cytochrome P450 family. | Corticosteroid 11-beta-dehydrogenase isozyme 2; Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. | 0.951 |
CYP11B2 | HSD17B8 | ENSOCUP00000012891 | ENSOCUP00000017884 | Uncharacterized protein; Belongs to the cytochrome P450 family. | Hydroxysteroid 17-beta dehydrogenase 8. | 0.919 |
CYP11B2 | HSD3B7 | ENSOCUP00000012891 | ENSOCUP00000034044 | Uncharacterized protein; Belongs to the cytochrome P450 family. | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; Belongs to the 3-beta-HSD family. | 0.549 |
CYP11B2 | LOC100346986 | ENSOCUP00000012891 | ENSOCUP00000034335 | Uncharacterized protein; Belongs to the cytochrome P450 family. | 3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. | 0.956 |
CYP11B2 | SRD5A1 | ENSOCUP00000012891 | ENSOCUP00000014623 | Uncharacterized protein; Belongs to the cytochrome P450 family. | 3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. | 0.925 |
CYP11B2 | SRD5A2 | ENSOCUP00000012891 | ENSOCUP00000001070 | Uncharacterized protein; Belongs to the cytochrome P450 family. | 3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. | 0.924 |