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AKR1D1 protein (Oryctolagus cuniculus) - STRING interaction network
"AKR1D1" - 3-oxo-5-beta-steroid 4-dehydrogenase in Oryctolagus cuniculus
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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AKR1D13-oxo-5-beta-steroid 4-dehydrogenase; Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates; Belongs to the aldo/keto reductase family (326 aa)    
Predicted Functional Partners:
HSD3B7
Uncharacterized protein; Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 (155 aa)
   
 
  0.974
SRD5A2
Steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (254 aa)
     
 
  0.962
CYP8B1
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; Involved in bile acid synthesis and is responsible for the conversion of 7-alpha-hydroxy-4-cholesten-3-one into 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha-hydroxylated C27 steroids; Belongs to the cytochrome P450 family (500 aa)
     
 
  0.961
SRD5A1
Steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) (255 aa)
         
  0.949
HSD11B1
Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone (292 aa)
     
 
  0.922
HSD11B2
Corticosteroid 11-beta-dehydrogenase isozyme 2; Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids (346 aa)
         
  0.915
HSD17B3
Hydroxysteroid (17-beta) dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family (310 aa)
     
 
  0.915
CYP17A1
Cytochrome P450, family 17, subfamily A, polypeptide 1 (508 aa)
     
 
  0.913
HSD17B2
Hydroxysteroid (17-beta) dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family (388 aa)
     
 
  0.913
CYP19A1
Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens (503 aa)
     
 
  0.911
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, Oryctolagus cuniculus, domestic rabbit, rabbit, rabbits
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