node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAN | CD44 | ENSOCUP00000024918 | ENSOCUP00000048202 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | CD44 molecule (Indian blood group). | 0.766 |
ACAN | ENSOCUP00000036760 | ENSOCUP00000024918 | ENSOCUP00000036760 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Uncharacterized protein. | 0.516 |
ACAN | TIMP1 | ENSOCUP00000024918 | ENSOCUP00000009228 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). | 0.658 |
ACAN | TIMP3 | ENSOCUP00000024918 | ENSOCUP00000007183 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli (By similarity). | 0.700 |
CD44 | ACAN | ENSOCUP00000048202 | ENSOCUP00000024918 | CD44 molecule (Indian blood group). | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.766 |
CD44 | ENSOCUP00000036760 | ENSOCUP00000048202 | ENSOCUP00000036760 | CD44 molecule (Indian blood group). | Uncharacterized protein. | 0.468 |
CD44 | TIMP1 | ENSOCUP00000048202 | ENSOCUP00000009228 | CD44 molecule (Indian blood group). | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). | 0.689 |
CD44 | TIMP3 | ENSOCUP00000048202 | ENSOCUP00000007183 | CD44 molecule (Indian blood group). | Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli (By similarity). | 0.452 |
ENSOCUP00000036760 | ACAN | ENSOCUP00000036760 | ENSOCUP00000024918 | Uncharacterized protein. | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.516 |
ENSOCUP00000036760 | CD44 | ENSOCUP00000036760 | ENSOCUP00000048202 | Uncharacterized protein. | CD44 molecule (Indian blood group). | 0.468 |
ENSOCUP00000036760 | FGFR1OP2 | ENSOCUP00000036760 | ENSOCUP00000007204 | Uncharacterized protein. | FGFR1 oncogene partner 2. | 0.407 |
ENSOCUP00000036760 | LOC103348521 | ENSOCUP00000036760 | ENSOCUP00000026817 | Uncharacterized protein. | NTR domain-containing protein. | 0.418 |
ENSOCUP00000036760 | OR51D1 | ENSOCUP00000036760 | ENSOCUP00000012376 | Uncharacterized protein. | Olfactory receptor. | 0.563 |
ENSOCUP00000036760 | TIMP1 | ENSOCUP00000036760 | ENSOCUP00000009228 | Uncharacterized protein. | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). | 0.418 |
ENSOCUP00000036760 | TIMP3 | ENSOCUP00000036760 | ENSOCUP00000007183 | Uncharacterized protein. | Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli (By similarity). | 0.418 |
ENSOCUP00000036760 | TIMP4 | ENSOCUP00000036760 | ENSOCUP00000013706 | Uncharacterized protein. | Metalloproteinase inhibitor 4; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family. | 0.418 |
FGFR1OP2 | ENSOCUP00000036760 | ENSOCUP00000007204 | ENSOCUP00000036760 | FGFR1 oncogene partner 2. | Uncharacterized protein. | 0.407 |
LOC103348521 | ENSOCUP00000036760 | ENSOCUP00000026817 | ENSOCUP00000036760 | NTR domain-containing protein. | Uncharacterized protein. | 0.418 |
OR51D1 | ENSOCUP00000036760 | ENSOCUP00000012376 | ENSOCUP00000036760 | Olfactory receptor. | Uncharacterized protein. | 0.563 |
TIMP1 | ACAN | ENSOCUP00000009228 | ENSOCUP00000024918 | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.658 |