MEF2A protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

MEF2A

Myocyte enhancer factor 2A. (511 aa)

Predicted Functional Partners:

MEF2D

0.978

NFATC4

0.928

NFATC2

0.920

NFATC1

0.917

NFATC3

0.910

NKX2-5

0.903

EP300

0.892

MYOG

0.852

MYOD1

0.841

HDAC4

0.837

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EP300	HDAC4	ENSOCUP00000009840	ENSOCUP00000016303	E1A binding protein p300.	Hist_deacetyl domain-containing protein.	0.630
EP300	MEF2A	ENSOCUP00000009840	ENSOCUP00000018692	E1A binding protein p300.	Myocyte enhancer factor 2A.	0.892
EP300	MEF2D	ENSOCUP00000009840	ENSOCUP00000010475	E1A binding protein p300.	Myocyte enhancer factor 2D.	0.636
EP300	MYOD1	ENSOCUP00000009840	ENSOCUP00000024511	E1A binding protein p300.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.860
EP300	NFATC1	ENSOCUP00000009840	ENSOCUP00000005601	E1A binding protein p300.	RHD domain-containing protein.	0.407
HDAC4	EP300	ENSOCUP00000016303	ENSOCUP00000009840	Hist_deacetyl domain-containing protein.	E1A binding protein p300.	0.630
HDAC4	MEF2A	ENSOCUP00000016303	ENSOCUP00000018692	Hist_deacetyl domain-containing protein.	Myocyte enhancer factor 2A.	0.837
HDAC4	MEF2D	ENSOCUP00000016303	ENSOCUP00000010475	Hist_deacetyl domain-containing protein.	Myocyte enhancer factor 2D.	0.914
HDAC4	MYOD1	ENSOCUP00000016303	ENSOCUP00000024511	Hist_deacetyl domain-containing protein.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.518
HDAC4	MYOG	ENSOCUP00000016303	ENSOCUP00000009928	Hist_deacetyl domain-containing protein.	Myogenin.	0.658
MEF2A	EP300	ENSOCUP00000018692	ENSOCUP00000009840	Myocyte enhancer factor 2A.	E1A binding protein p300.	0.892
MEF2A	HDAC4	ENSOCUP00000018692	ENSOCUP00000016303	Myocyte enhancer factor 2A.	Hist_deacetyl domain-containing protein.	0.837
MEF2A	MEF2D	ENSOCUP00000018692	ENSOCUP00000010475	Myocyte enhancer factor 2A.	Myocyte enhancer factor 2D.	0.978
MEF2A	MYOD1	ENSOCUP00000018692	ENSOCUP00000024511	Myocyte enhancer factor 2A.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.841
MEF2A	MYOG	ENSOCUP00000018692	ENSOCUP00000009928	Myocyte enhancer factor 2A.	Myogenin.	0.852
MEF2A	NFATC1	ENSOCUP00000018692	ENSOCUP00000005601	Myocyte enhancer factor 2A.	RHD domain-containing protein.	0.917
MEF2A	NFATC2	ENSOCUP00000018692	ENSOCUP00000044727	Myocyte enhancer factor 2A.	Nuclear factor of activated T cells 2.	0.920
MEF2A	NFATC3	ENSOCUP00000018692	ENSOCUP00000008660	Myocyte enhancer factor 2A.	Nuclear factor of activated T cells 3.	0.910
MEF2A	NFATC4	ENSOCUP00000018692	ENSOCUP00000030284	Myocyte enhancer factor 2A.	Nuclear factor of activated T cells 4.	0.928
MEF2A	NKX2-5	ENSOCUP00000018692	ENSOCUP00000000038	Myocyte enhancer factor 2A.	NK2 homeobox 5.	0.903