node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALG2 | ANXA11 | ENSOCUP00000004920 | ENSOCUP00000003940 | ALG2 alpha-1,3/1,6-mannosyltransferase. | Annexin A11; Required for midbody formation and completion of the terminal phase of cytokinesis (By similarity). Binds specifically to calcyclin in a calcium-dependent manner; Belongs to the annexin family. | 0.821 |
ALG2 | S100A6 | ENSOCUP00000004920 | ENSOCUP00000031840 | ALG2 alpha-1,3/1,6-mannosyltransferase. | Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity). | 0.524 |
ANXA11 | ALG2 | ENSOCUP00000003940 | ENSOCUP00000004920 | Annexin A11; Required for midbody formation and completion of the terminal phase of cytokinesis (By similarity). Binds specifically to calcyclin in a calcium-dependent manner; Belongs to the annexin family. | ALG2 alpha-1,3/1,6-mannosyltransferase. | 0.821 |
ANXA11 | ANXA7 | ENSOCUP00000003940 | ENSOCUP00000045853 | Annexin A11; Required for midbody formation and completion of the terminal phase of cytokinesis (By similarity). Binds specifically to calcyclin in a calcium-dependent manner; Belongs to the annexin family. | Annexin. | 0.914 |
ANXA11 | CD63 | ENSOCUP00000003940 | ENSOCUP00000018861 | Annexin A11; Required for midbody formation and completion of the terminal phase of cytokinesis (By similarity). Binds specifically to calcyclin in a calcium-dependent manner; Belongs to the annexin family. | CD63 antigen; Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal tr [...] | 0.682 |
ANXA11 | CD9 | ENSOCUP00000003940 | ENSOCUP00000045374 | Annexin A11; Required for midbody formation and completion of the terminal phase of cytokinesis (By similarity). Binds specifically to calcyclin in a calcium-dependent manner; Belongs to the annexin family. | Tetraspanin. | 0.581 |
ANXA11 | LOC100344315 | ENSOCUP00000003940 | ENSOCUP00000032113 | Annexin A11; Required for midbody formation and completion of the terminal phase of cytokinesis (By similarity). Binds specifically to calcyclin in a calcium-dependent manner; Belongs to the annexin family. | Uncharacterized protein. | 0.637 |
ANXA11 | PLG | ENSOCUP00000003940 | ENSOCUP00000001518 | Annexin A11; Required for midbody formation and completion of the terminal phase of cytokinesis (By similarity). Binds specifically to calcyclin in a calcium-dependent manner; Belongs to the annexin family. | Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.637 |
ANXA11 | S100A6 | ENSOCUP00000003940 | ENSOCUP00000031840 | Annexin A11; Required for midbody formation and completion of the terminal phase of cytokinesis (By similarity). Binds specifically to calcyclin in a calcium-dependent manner; Belongs to the annexin family. | Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity). | 0.947 |
ANXA11 | S100a10 | ENSOCUP00000003940 | ENSOCUP00000004505 | Annexin A11; Required for midbody formation and completion of the terminal phase of cytokinesis (By similarity). Binds specifically to calcyclin in a calcium-dependent manner; Belongs to the annexin family. | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. | 0.583 |
ANXA11 | SEC31A | ENSOCUP00000003940 | ENSOCUP00000026752 | Annexin A11; Required for midbody formation and completion of the terminal phase of cytokinesis (By similarity). Binds specifically to calcyclin in a calcium-dependent manner; Belongs to the annexin family. | SEC31 homolog A, COPII coat complex component. | 0.632 |
ANXA11 | TSG101 | ENSOCUP00000003940 | ENSOCUP00000031910 | Annexin A11; Required for midbody formation and completion of the terminal phase of cytokinesis (By similarity). Binds specifically to calcyclin in a calcium-dependent manner; Belongs to the annexin family. | Tumor susceptibility 101. | 0.640 |
ANXA7 | ANXA11 | ENSOCUP00000045853 | ENSOCUP00000003940 | Annexin. | Annexin A11; Required for midbody formation and completion of the terminal phase of cytokinesis (By similarity). Binds specifically to calcyclin in a calcium-dependent manner; Belongs to the annexin family. | 0.914 |
ANXA7 | CD63 | ENSOCUP00000045853 | ENSOCUP00000018861 | Annexin. | CD63 antigen; Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal tr [...] | 0.743 |
ANXA7 | CD9 | ENSOCUP00000045853 | ENSOCUP00000045374 | Annexin. | Tetraspanin. | 0.697 |
ANXA7 | PLG | ENSOCUP00000045853 | ENSOCUP00000001518 | Annexin. | Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.719 |
ANXA7 | S100a10 | ENSOCUP00000045853 | ENSOCUP00000004505 | Annexin. | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. | 0.575 |
ANXA7 | TSG101 | ENSOCUP00000045853 | ENSOCUP00000031910 | Annexin. | Tumor susceptibility 101. | 0.646 |
CD63 | ANXA11 | ENSOCUP00000018861 | ENSOCUP00000003940 | CD63 antigen; Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal tr [...] | Annexin A11; Required for midbody formation and completion of the terminal phase of cytokinesis (By similarity). Binds specifically to calcyclin in a calcium-dependent manner; Belongs to the annexin family. | 0.682 |
CD63 | ANXA7 | ENSOCUP00000018861 | ENSOCUP00000045853 | CD63 antigen; Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal tr [...] | Annexin. | 0.743 |