node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP1A1 | ATP1A2 | ENSOCUP00000024821 | ENSOCUP00000025793 | Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity). May contribute to blood-heart barrier properties of endocardial endothelium and may control cardiac performance via endothelial Na(+)/H(+) exchange. | Sodium/potassium-transporting ATPase subunit alpha. | 0.902 |
ATP1A1 | ATP1A3 | ENSOCUP00000024821 | ENSOCUP00000045460 | Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity). May contribute to blood-heart barrier properties of endocardial endothelium and may control cardiac performance via endothelial Na(+)/H(+) exchange. | Sodium/potassium-transporting ATPase subunit alpha. | 0.923 |
ATP1A1 | ATP1A4 | ENSOCUP00000024821 | ENSOCUP00000015184 | Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity). May contribute to blood-heart barrier properties of endocardial endothelium and may control cardiac performance via endothelial Na(+)/H(+) exchange. | Sodium/potassium-transporting ATPase subunit alpha. | 0.905 |
ATP1A1 | ATP1B1 | ENSOCUP00000024821 | ENSOCUP00000039420 | Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity). May contribute to blood-heart barrier properties of endocardial endothelium and may control cardiac performance via endothelial Na(+)/H(+) exchange. | Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). | 0.997 |
ATP1A1 | ATP1B2 | ENSOCUP00000024821 | ENSOCUP00000002598 | Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity). May contribute to blood-heart barrier properties of endocardial endothelium and may control cardiac performance via endothelial Na(+)/H(+) exchange. | Sodium/potassium-transporting ATPase subunit beta-2; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known (By similarity). | 0.983 |
ATP1A1 | ATP1B3 | ENSOCUP00000024821 | ENSOCUP00000000299 | Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity). May contribute to blood-heart barrier properties of endocardial endothelium and may control cardiac performance via endothelial Na(+)/H(+) exchange. | Sodium/potassium-transporting ATPase subunit beta-3; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known (By similarity); Belongs to the X(+)/potassium ATPases subunit beta family. | 0.992 |
ATP1A1 | ATP1B4 | ENSOCUP00000024821 | ENSOCUP00000003426 | Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity). May contribute to blood-heart barrier properties of endocardial endothelium and may control cardiac performance via endothelial Na(+)/H(+) exchange. | Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. | 0.957 |
ATP1A1 | FXYD1 | ENSOCUP00000024821 | ENSOCUP00000022422 | Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity). May contribute to blood-heart barrier properties of endocardial endothelium and may control cardiac performance via endothelial Na(+)/H(+) exchange. | Phospholemman; Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. Belongs to the FXYD family. | 0.954 |
ATP1A1 | LOC103349229 | ENSOCUP00000024821 | ENSOCUP00000047357 | Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity). May contribute to blood-heart barrier properties of endocardial endothelium and may control cardiac performance via endothelial Na(+)/H(+) exchange. | FXYD domain-containing ion transport regulator; Belongs to the FXYD family. | 0.985 |
ATP1A1 | PRKACB | ENSOCUP00000024821 | ENSOCUP00000043583 | Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity). May contribute to blood-heart barrier properties of endocardial endothelium and may control cardiac performance via endothelial Na(+)/H(+) exchange. | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. | 0.919 |
ATP1A2 | ATP1A1 | ENSOCUP00000025793 | ENSOCUP00000024821 | Sodium/potassium-transporting ATPase subunit alpha. | Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity). May contribute to blood-heart barrier properties of endocardial endothelium and may control cardiac performance via endothelial Na(+)/H(+) exchange. | 0.902 |
ATP1A2 | ATP1A3 | ENSOCUP00000025793 | ENSOCUP00000045460 | Sodium/potassium-transporting ATPase subunit alpha. | Sodium/potassium-transporting ATPase subunit alpha. | 0.924 |
ATP1A2 | ATP1A4 | ENSOCUP00000025793 | ENSOCUP00000015184 | Sodium/potassium-transporting ATPase subunit alpha. | Sodium/potassium-transporting ATPase subunit alpha. | 0.905 |
ATP1A2 | ATP1B1 | ENSOCUP00000025793 | ENSOCUP00000039420 | Sodium/potassium-transporting ATPase subunit alpha. | Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). | 0.994 |
ATP1A2 | ATP1B2 | ENSOCUP00000025793 | ENSOCUP00000002598 | Sodium/potassium-transporting ATPase subunit alpha. | Sodium/potassium-transporting ATPase subunit beta-2; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known (By similarity). | 0.992 |
ATP1A2 | ATP1B3 | ENSOCUP00000025793 | ENSOCUP00000000299 | Sodium/potassium-transporting ATPase subunit alpha. | Sodium/potassium-transporting ATPase subunit beta-3; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known (By similarity); Belongs to the X(+)/potassium ATPases subunit beta family. | 0.985 |
ATP1A2 | ATP1B4 | ENSOCUP00000025793 | ENSOCUP00000003426 | Sodium/potassium-transporting ATPase subunit alpha. | Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. | 0.978 |
ATP1A2 | FXYD1 | ENSOCUP00000025793 | ENSOCUP00000022422 | Sodium/potassium-transporting ATPase subunit alpha. | Phospholemman; Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. Belongs to the FXYD family. | 0.950 |
ATP1A2 | LOC103349229 | ENSOCUP00000025793 | ENSOCUP00000047357 | Sodium/potassium-transporting ATPase subunit alpha. | FXYD domain-containing ion transport regulator; Belongs to the FXYD family. | 0.982 |
ATP1A2 | PRKACB | ENSOCUP00000025793 | ENSOCUP00000043583 | Sodium/potassium-transporting ATPase subunit alpha. | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. | 0.912 |