STAT5A protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

STAT5A

Signal transducer and activator of transcription. (793 aa)

Predicted Functional Partners:

JAK2

0.996

JAK1

0.994

EGFR

0.983

STAT3

0.972

SOCS2

0.966

STAT5B

0.966

ERBB4

0.965

CISH

0.963

FLT3

0.961

SOCS4

0.957

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CISH	EGFR	ENSOCUP00000019141	ENSOCUP00000009041	Cytokine inducible SH2 containing protein.	Receptor protein-tyrosine kinase.	0.562
CISH	JAK1	ENSOCUP00000019141	ENSOCUP00000005398	Cytokine inducible SH2 containing protein.	Tyrosine-protein kinase.	0.663
CISH	JAK2	ENSOCUP00000019141	ENSOCUP00000014491	Cytokine inducible SH2 containing protein.	Tyrosine-protein kinase.	0.806
CISH	SOCS2	ENSOCUP00000019141	ENSOCUP00000001084	Cytokine inducible SH2 containing protein.	Suppressor of cytokine signaling 2.	0.508
CISH	SOCS4	ENSOCUP00000019141	ENSOCUP00000003465	Cytokine inducible SH2 containing protein.	Suppressor of cytokine signaling 4.	0.612
CISH	STAT3	ENSOCUP00000019141	ENSOCUP00000009494	Cytokine inducible SH2 containing protein.	Signal transducer and activator of transcription.	0.963
CISH	STAT5A	ENSOCUP00000019141	ENSOCUP00000024325	Cytokine inducible SH2 containing protein.	Signal transducer and activator of transcription.	0.963
CISH	STAT5B	ENSOCUP00000019141	ENSOCUP00000004399	Cytokine inducible SH2 containing protein.	Signal transducer and activator of transcription.	0.956
EGFR	CISH	ENSOCUP00000009041	ENSOCUP00000019141	Receptor protein-tyrosine kinase.	Cytokine inducible SH2 containing protein.	0.562
EGFR	ERBB4	ENSOCUP00000009041	ENSOCUP00000035750	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.944
EGFR	FLT3	ENSOCUP00000009041	ENSOCUP00000004237	Receptor protein-tyrosine kinase.	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.508
EGFR	JAK1	ENSOCUP00000009041	ENSOCUP00000005398	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.953
EGFR	JAK2	ENSOCUP00000009041	ENSOCUP00000014491	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.973
EGFR	SOCS4	ENSOCUP00000009041	ENSOCUP00000003465	Receptor protein-tyrosine kinase.	Suppressor of cytokine signaling 4.	0.409
EGFR	STAT3	ENSOCUP00000009041	ENSOCUP00000009494	Receptor protein-tyrosine kinase.	Signal transducer and activator of transcription.	0.989
EGFR	STAT5A	ENSOCUP00000009041	ENSOCUP00000024325	Receptor protein-tyrosine kinase.	Signal transducer and activator of transcription.	0.983
EGFR	STAT5B	ENSOCUP00000009041	ENSOCUP00000004399	Receptor protein-tyrosine kinase.	Signal transducer and activator of transcription.	0.983
ERBB4	EGFR	ENSOCUP00000035750	ENSOCUP00000009041	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.944
ERBB4	FLT3	ENSOCUP00000035750	ENSOCUP00000004237	Receptor protein-tyrosine kinase.	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.457
ERBB4	JAK1	ENSOCUP00000035750	ENSOCUP00000005398	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.453