node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALDOA | ALDOC | ENSOCUP00000041095 | ENSOCUP00000011870 | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein. Belongs to the class I fructose-bisphosphate aldolase family. | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. | 0.971 |
ALDOA | ENO1 | ENSOCUP00000041095 | ENSOCUP00000035294 | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein. Belongs to the class I fructose-bisphosphate aldolase family. | Uncharacterized protein. | 0.929 |
ALDOA | ENO2 | ENSOCUP00000041095 | ENSOCUP00000003109 | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein. Belongs to the class I fructose-bisphosphate aldolase family. | Beta-enolase; Appears to have a function in striated muscle development and regeneration; Belongs to the enolase family. | 0.978 |
ALDOA | ENO3 | ENSOCUP00000041095 | ENSOCUP00000025169 | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein. Belongs to the class I fructose-bisphosphate aldolase family. | Beta-enolase. | 0.988 |
ALDOA | FBP1 | ENSOCUP00000041095 | ENSOCUP00000046019 | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein. Belongs to the class I fructose-bisphosphate aldolase family. | Fructose-1,6-bisphosphatase 1; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism [...] | 0.980 |
ALDOA | GPI | ENSOCUP00000041095 | ENSOCUP00000036902 | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein. Belongs to the class I fructose-bisphosphate aldolase family. | Glucose-6-phosphate isomerase; In the cytoplasm, catalyzes the conversion of glucose-6- phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity). | 0.784 |
ALDOA | PFKP | ENSOCUP00000041095 | ENSOCUP00000026775 | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein. Belongs to the class I fructose-bisphosphate aldolase family. | ATP-dependent 6-phosphofructokinase, platelet type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. | 0.893 |
ALDOA | PGK1 | ENSOCUP00000041095 | ENSOCUP00000012659 | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein. Belongs to the class I fructose-bisphosphate aldolase family. | Phosphoglycerate kinase. | 0.924 |
ALDOA | PKM | ENSOCUP00000041095 | ENSOCUP00000005301 | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein. Belongs to the class I fructose-bisphosphate aldolase family. | Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (By similarity). Stimulates POU5F1-mediated transcriptional activation (By similarity). Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity). | 0.907 |
ALDOA | TPI1 | ENSOCUP00000041095 | ENSOCUP00000019840 | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein. Belongs to the class I fructose-bisphosphate aldolase family. | Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. | 0.994 |
ALDOC | ALDOA | ENSOCUP00000011870 | ENSOCUP00000041095 | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein. Belongs to the class I fructose-bisphosphate aldolase family. | 0.971 |
ALDOC | ENO1 | ENSOCUP00000011870 | ENSOCUP00000035294 | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. | Uncharacterized protein. | 0.794 |
ALDOC | ENO2 | ENSOCUP00000011870 | ENSOCUP00000003109 | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. | Beta-enolase; Appears to have a function in striated muscle development and regeneration; Belongs to the enolase family. | 0.963 |
ALDOC | ENO3 | ENSOCUP00000011870 | ENSOCUP00000025169 | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. | Beta-enolase. | 0.962 |
ALDOC | FBP1 | ENSOCUP00000011870 | ENSOCUP00000046019 | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. | Fructose-1,6-bisphosphatase 1; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism [...] | 0.984 |
ALDOC | GPI | ENSOCUP00000011870 | ENSOCUP00000036902 | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. | Glucose-6-phosphate isomerase; In the cytoplasm, catalyzes the conversion of glucose-6- phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity). | 0.798 |
ALDOC | PFKP | ENSOCUP00000011870 | ENSOCUP00000026775 | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. | ATP-dependent 6-phosphofructokinase, platelet type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. | 0.837 |
ALDOC | PGK1 | ENSOCUP00000011870 | ENSOCUP00000012659 | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. | Phosphoglycerate kinase. | 0.853 |
ALDOC | PKM | ENSOCUP00000011870 | ENSOCUP00000005301 | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. | Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (By similarity). Stimulates POU5F1-mediated transcriptional activation (By similarity). Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity). | 0.680 |
ALDOC | TPI1 | ENSOCUP00000011870 | ENSOCUP00000019840 | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. | Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. | 0.991 |