node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABI1 | ABI3 | ENSP00000365312 | ENSP00000225941 | Abl interactor 1; May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl- mediated phosphorylation of ENAH. Recru [...] | ABI gene family member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility; Belongs to the ABI family. | 0.752 |
ABI1 | ABI3BP | ENSP00000365312 | ENSP00000284322 | Abl interactor 1; May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl- mediated phosphorylation of ENAH. Recru [...] | Target of Nesh-SH3; ABI family member 3 binding protein. | 0.688 |
ABI3 | ABI1 | ENSP00000225941 | ENSP00000365312 | ABI gene family member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility; Belongs to the ABI family. | Abl interactor 1; May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl- mediated phosphorylation of ENAH. Recru [...] | 0.752 |
ABI3 | ABI3BP | ENSP00000225941 | ENSP00000284322 | ABI gene family member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility; Belongs to the ABI family. | Target of Nesh-SH3; ABI family member 3 binding protein. | 0.998 |
ABI3BP | ABI1 | ENSP00000284322 | ENSP00000365312 | Target of Nesh-SH3; ABI family member 3 binding protein. | Abl interactor 1; May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl- mediated phosphorylation of ENAH. Recru [...] | 0.688 |
ABI3BP | ABI3 | ENSP00000284322 | ENSP00000225941 | Target of Nesh-SH3; ABI family member 3 binding protein. | ABI gene family member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility; Belongs to the ABI family. | 0.998 |
ABI3BP | AP5B1 | ENSP00000284322 | ENSP00000454303 | Target of Nesh-SH3; ABI family member 3 binding protein. | AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. | 0.451 |
ABI3BP | AZI2 | ENSP00000284322 | ENSP00000419371 | Target of Nesh-SH3; ABI family member 3 binding protein. | 5-azacytidine-induced protein 2; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1. | 0.409 |
ABI3BP | CCDC80 | ENSP00000284322 | ENSP00000206423 | Target of Nesh-SH3; ABI family member 3 binding protein. | Coiled-coil domain-containing protein 80; Promotes cell adhesion and matrix assembly. | 0.428 |
ABI3BP | FXYD2 | ENSP00000284322 | ENSP00000292079 | Target of Nesh-SH3; ABI family member 3 binding protein. | Sodium/potassium-transporting ATPase subunit gamma; May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase; Belongs to the FXYD family. | 0.542 |
ABI3BP | MAMDC2 | ENSP00000284322 | ENSP00000366387 | Target of Nesh-SH3; ABI family member 3 binding protein. | MAM domain containing 2. | 0.427 |
ABI3BP | NDUFAF6 | ENSP00000284322 | ENSP00000379430 | Target of Nesh-SH3; ABI family member 3 binding protein. | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6; Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) at early stages. May play a role in the biogenesis of MT-ND1. | 0.424 |
ABI3BP | SCARB2 | ENSP00000284322 | ENSP00000264896 | Target of Nesh-SH3; ABI family member 3 binding protein. | Lysosome membrane protein 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. | 0.410 |
ABI3BP | TMEM51 | ENSP00000284322 | ENSP00000365176 | Target of Nesh-SH3; ABI family member 3 binding protein. | Transmembrane protein 51. | 0.434 |
AP5B1 | ABI3BP | ENSP00000454303 | ENSP00000284322 | AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. | Target of Nesh-SH3; ABI family member 3 binding protein. | 0.451 |
AZI2 | ABI3BP | ENSP00000419371 | ENSP00000284322 | 5-azacytidine-induced protein 2; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1. | Target of Nesh-SH3; ABI family member 3 binding protein. | 0.409 |
AZI2 | NDUFAF6 | ENSP00000419371 | ENSP00000379430 | 5-azacytidine-induced protein 2; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1. | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6; Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) at early stages. May play a role in the biogenesis of MT-ND1. | 0.415 |
AZI2 | TMEM51 | ENSP00000419371 | ENSP00000365176 | 5-azacytidine-induced protein 2; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1. | Transmembrane protein 51. | 0.442 |
CCDC80 | ABI3BP | ENSP00000206423 | ENSP00000284322 | Coiled-coil domain-containing protein 80; Promotes cell adhesion and matrix assembly. | Target of Nesh-SH3; ABI family member 3 binding protein. | 0.428 |
FXYD2 | ABI3BP | ENSP00000292079 | ENSP00000284322 | Sodium/potassium-transporting ATPase subunit gamma; May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase; Belongs to the FXYD family. | Target of Nesh-SH3; ABI family member 3 binding protein. | 0.542 |