node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAN | ADAMTS15 | ENSP00000387356 | ENSP00000299164 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. | ADAM metallopeptidase with thrombospondin type 1 motif 15. | 0.672 |
ACAN | BCAN | ENSP00000387356 | ENSP00000331210 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. | Brevican core protein; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans; Belongs to the aggrecan/versican proteoglycan family. | 0.989 |
ADAMTS15 | ACAN | ENSP00000299164 | ENSP00000387356 | ADAM metallopeptidase with thrombospondin type 1 motif 15. | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. | 0.672 |
ADAMTS15 | B3GLCT | ENSP00000299164 | ENSP00000343002 | ADAM metallopeptidase with thrombospondin type 1 motif 15. | Beta-1,3-glucosyltransferase; O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan. | 0.430 |
ADAMTS15 | BCAN | ENSP00000299164 | ENSP00000331210 | ADAM metallopeptidase with thrombospondin type 1 motif 15. | Brevican core protein; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans; Belongs to the aggrecan/versican proteoglycan family. | 0.466 |
ADAMTS15 | CD36 | ENSP00000299164 | ENSP00000415743 | ADAM metallopeptidase with thrombospondin type 1 motif 15. | Platelet glycoprotein 4; Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor- ligand complexes. The depende [...] | 0.467 |
ADAMTS15 | FURIN | ENSP00000299164 | ENSP00000483552 | ADAM metallopeptidase with thrombospondin type 1 motif 15. | Furin; Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation. (Microbial infection) Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin. | 0.542 |
ADAMTS15 | POFUT2 | ENSP00000299164 | ENSP00000339613 | ADAM metallopeptidase with thrombospondin type 1 motif 15. | GDP-fucose protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and [...] | 0.438 |
ADAMTS15 | SCARB1 | ENSP00000299164 | ENSP00000261693 | ADAM metallopeptidase with thrombospondin type 1 motif 15. | Scavenger receptor class B member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Belongs to the CD36 family. | 0.430 |
ADAMTS15 | SCARB2 | ENSP00000299164 | ENSP00000264896 | ADAM metallopeptidase with thrombospondin type 1 motif 15. | Lysosome membrane protein 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. | 0.451 |
ADAMTS15 | SERPINE3 | ENSP00000299164 | ENSP00000428316 | ADAM metallopeptidase with thrombospondin type 1 motif 15. | Serpin E3; Probable serine protease inhibitor. | 0.429 |
ADAMTS15 | THSD1 | ENSP00000299164 | ENSP00000258613 | ADAM metallopeptidase with thrombospondin type 1 motif 15. | Thrombospondin type-1 domain-containing protein 1; Thrombospondin type 1 domain containing 1. | 0.446 |
B3GLCT | ADAMTS15 | ENSP00000343002 | ENSP00000299164 | Beta-1,3-glucosyltransferase; O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan. | ADAM metallopeptidase with thrombospondin type 1 motif 15. | 0.430 |
B3GLCT | POFUT2 | ENSP00000343002 | ENSP00000339613 | Beta-1,3-glucosyltransferase; O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan. | GDP-fucose protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and [...] | 0.958 |
B3GLCT | THSD1 | ENSP00000343002 | ENSP00000258613 | Beta-1,3-glucosyltransferase; O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan. | Thrombospondin type-1 domain-containing protein 1; Thrombospondin type 1 domain containing 1. | 0.409 |
BCAN | ACAN | ENSP00000331210 | ENSP00000387356 | Brevican core protein; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans; Belongs to the aggrecan/versican proteoglycan family. | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. | 0.989 |
BCAN | ADAMTS15 | ENSP00000331210 | ENSP00000299164 | Brevican core protein; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans; Belongs to the aggrecan/versican proteoglycan family. | ADAM metallopeptidase with thrombospondin type 1 motif 15. | 0.466 |
CD36 | ADAMTS15 | ENSP00000415743 | ENSP00000299164 | Platelet glycoprotein 4; Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor- ligand complexes. The depende [...] | ADAM metallopeptidase with thrombospondin type 1 motif 15. | 0.467 |
CD36 | FURIN | ENSP00000415743 | ENSP00000483552 | Platelet glycoprotein 4; Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor- ligand complexes. The depende [...] | Furin; Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation. (Microbial infection) Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin. | 0.411 |
FURIN | ADAMTS15 | ENSP00000483552 | ENSP00000299164 | Furin; Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation. (Microbial infection) Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin. | ADAM metallopeptidase with thrombospondin type 1 motif 15. | 0.542 |