node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADGRA1 | ADGRD2 | ENSP00000376384 | ENSP00000335156 | Adhesion G protein-coupled receptor A1; Orphan receptor. | Adhesion G-protein coupled receptor D2; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. | 0.621 |
ADGRA1 | ADGRF2 | ENSP00000376384 | ENSP00000296862 | Adhesion G protein-coupled receptor A1; Orphan receptor. | Adhesion G-protein coupled receptor F2; Orphan receptor. | 0.645 |
ADGRA1 | ADGRG3 | ENSP00000376384 | ENSP00000332900 | Adhesion G protein-coupled receptor A1; Orphan receptor. | Adhesion G protein-coupled receptor G3; Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42. Regulates B-cell development (By similarity). Seems to signal through G-alpha(q)-proteins. | 0.638 |
ADGRA1 | ADGRG5 | ENSP00000376384 | ENSP00000342981 | Adhesion G protein-coupled receptor A1; Orphan receptor. | Adhesion G-protein coupled receptor G5; Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking). | 0.664 |
ADGRA1 | ADGRG7 | ENSP00000376384 | ENSP00000273352 | Adhesion G protein-coupled receptor A1; Orphan receptor. | Adhesion G-protein coupled receptor G7; Orphan receptor. | 0.629 |
ADGRA1 | ADGRL1 | ENSP00000376384 | ENSP00000340688 | Adhesion G protein-coupled receptor A1; Orphan receptor. | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity). | 0.659 |
ADGRA1 | ADGRL2 | ENSP00000376384 | ENSP00000359765 | Adhesion G protein-coupled receptor A1; Orphan receptor. | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. | 0.639 |
ADGRA1 | ADGRL3 | ENSP00000376384 | ENSP00000422533 | Adhesion G protein-coupled receptor A1; Orphan receptor. | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. | 0.630 |
ADGRA1 | KNDC1 | ENSP00000376384 | ENSP00000304437 | Adhesion G protein-coupled receptor A1; Orphan receptor. | Kinase non-catalytic C-lobe domain-containing protein 1; RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence. | 0.698 |
ADGRA1 | SCTR | ENSP00000376384 | ENSP00000019103 | Adhesion G protein-coupled receptor A1; Orphan receptor. | Secretin receptor; Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). In addition to regulating the pH of the duodena [...] | 0.817 |
ADGRD2 | ADGRA1 | ENSP00000335156 | ENSP00000376384 | Adhesion G-protein coupled receptor D2; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. | Adhesion G protein-coupled receptor A1; Orphan receptor. | 0.621 |
ADGRF2 | ADGRA1 | ENSP00000296862 | ENSP00000376384 | Adhesion G-protein coupled receptor F2; Orphan receptor. | Adhesion G protein-coupled receptor A1; Orphan receptor. | 0.645 |
ADGRG3 | ADGRA1 | ENSP00000332900 | ENSP00000376384 | Adhesion G protein-coupled receptor G3; Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42. Regulates B-cell development (By similarity). Seems to signal through G-alpha(q)-proteins. | Adhesion G protein-coupled receptor A1; Orphan receptor. | 0.638 |
ADGRG3 | ADGRG5 | ENSP00000332900 | ENSP00000342981 | Adhesion G protein-coupled receptor G3; Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42. Regulates B-cell development (By similarity). Seems to signal through G-alpha(q)-proteins. | Adhesion G-protein coupled receptor G5; Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking). | 0.435 |
ADGRG5 | ADGRA1 | ENSP00000342981 | ENSP00000376384 | Adhesion G-protein coupled receptor G5; Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking). | Adhesion G protein-coupled receptor A1; Orphan receptor. | 0.664 |
ADGRG5 | ADGRG3 | ENSP00000342981 | ENSP00000332900 | Adhesion G-protein coupled receptor G5; Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking). | Adhesion G protein-coupled receptor G3; Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42. Regulates B-cell development (By similarity). Seems to signal through G-alpha(q)-proteins. | 0.435 |
ADGRG7 | ADGRA1 | ENSP00000273352 | ENSP00000376384 | Adhesion G-protein coupled receptor G7; Orphan receptor. | Adhesion G protein-coupled receptor A1; Orphan receptor. | 0.629 |
ADGRL1 | ADGRA1 | ENSP00000340688 | ENSP00000376384 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity). | Adhesion G protein-coupled receptor A1; Orphan receptor. | 0.659 |
ADGRL2 | ADGRA1 | ENSP00000359765 | ENSP00000376384 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. | Adhesion G protein-coupled receptor A1; Orphan receptor. | 0.639 |
ADGRL3 | ADGRA1 | ENSP00000422533 | ENSP00000376384 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. | Adhesion G protein-coupled receptor A1; Orphan receptor. | 0.630 |