node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADGRA1 | ADGRF2 | ENSP00000376384 | ENSP00000296862 | Adhesion G protein-coupled receptor A1; Orphan receptor. | Adhesion G-protein coupled receptor F2; Orphan receptor. | 0.645 |
ADGRA1 | ADGRV1 | ENSP00000376384 | ENSP00000384582 | Adhesion G protein-coupled receptor A1; Orphan receptor. | Adhesion G-protein coupled receptor V1; G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing th [...] | 0.502 |
ADGRA2 | ADGRF2 | ENSP00000406367 | ENSP00000296862 | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. ADGRA2-tethering function does not rely [...] | Adhesion G-protein coupled receptor F2; Orphan receptor. | 0.608 |
ADGRA2 | ADGRV1 | ENSP00000406367 | ENSP00000384582 | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. ADGRA2-tethering function does not rely [...] | Adhesion G-protein coupled receptor V1; G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing th [...] | 0.429 |
ADGRA3 | ADGRF2 | ENSP00000334952 | ENSP00000296862 | Adhesion G protein-coupled receptor A3; Orphan receptor that may have a role in planar cell polarity pathway; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. | Adhesion G-protein coupled receptor F2; Orphan receptor. | 0.656 |
ADGRA3 | ADGRV1 | ENSP00000334952 | ENSP00000384582 | Adhesion G protein-coupled receptor A3; Orphan receptor that may have a role in planar cell polarity pathway; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. | Adhesion G-protein coupled receptor V1; G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing th [...] | 0.495 |
ADGRF2 | ADGRA1 | ENSP00000296862 | ENSP00000376384 | Adhesion G-protein coupled receptor F2; Orphan receptor. | Adhesion G protein-coupled receptor A1; Orphan receptor. | 0.645 |
ADGRF2 | ADGRA2 | ENSP00000296862 | ENSP00000406367 | Adhesion G-protein coupled receptor F2; Orphan receptor. | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. ADGRA2-tethering function does not rely [...] | 0.608 |
ADGRF2 | ADGRA3 | ENSP00000296862 | ENSP00000334952 | Adhesion G-protein coupled receptor F2; Orphan receptor. | Adhesion G protein-coupled receptor A3; Orphan receptor that may have a role in planar cell polarity pathway; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. | 0.656 |
ADGRF2 | ADGRV1 | ENSP00000296862 | ENSP00000384582 | Adhesion G-protein coupled receptor F2; Orphan receptor. | Adhesion G-protein coupled receptor V1; G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing th [...] | 0.423 |
ADGRF2 | C3AR1 | ENSP00000296862 | ENSP00000302079 | Adhesion G-protein coupled receptor F2; Orphan receptor. | C3a anaphylatoxin chemotactic receptor; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production; Belongs to the G-protein coupled receptor 1 family. | 0.448 |
ADGRF2 | CD2AP | ENSP00000296862 | ENSP00000352264 | Adhesion G-protein coupled receptor F2; Orphan receptor. | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glom [...] | 0.514 |
ADGRF2 | LRRC46 | ENSP00000296862 | ENSP00000269025 | Adhesion G-protein coupled receptor F2; Orphan receptor. | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46. | 0.428 |
ADGRF2 | NPHP3-ACAD11 | ENSP00000296862 | ENSP00000488520 | Adhesion G-protein coupled receptor F2; Orphan receptor. | NPHP3-ACAD11 readthrough. | 0.482 |
ADGRF2 | ZNF723 | ENSP00000296862 | ENSP00000494306 | Adhesion G-protein coupled receptor F2; Orphan receptor. | Zinc finger protein 723; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.571 |
ADGRV1 | ADGRA1 | ENSP00000384582 | ENSP00000376384 | Adhesion G-protein coupled receptor V1; G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing th [...] | Adhesion G protein-coupled receptor A1; Orphan receptor. | 0.502 |
ADGRV1 | ADGRA2 | ENSP00000384582 | ENSP00000406367 | Adhesion G-protein coupled receptor V1; G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing th [...] | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. ADGRA2-tethering function does not rely [...] | 0.429 |
ADGRV1 | ADGRA3 | ENSP00000384582 | ENSP00000334952 | Adhesion G-protein coupled receptor V1; G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing th [...] | Adhesion G protein-coupled receptor A3; Orphan receptor that may have a role in planar cell polarity pathway; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. | 0.495 |
ADGRV1 | ADGRF2 | ENSP00000384582 | ENSP00000296862 | Adhesion G-protein coupled receptor V1; G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing th [...] | Adhesion G-protein coupled receptor F2; Orphan receptor. | 0.423 |
C3AR1 | ADGRF2 | ENSP00000302079 | ENSP00000296862 | C3a anaphylatoxin chemotactic receptor; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production; Belongs to the G-protein coupled receptor 1 family. | Adhesion G-protein coupled receptor F2; Orphan receptor. | 0.448 |