STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AKR1E2Aldo-keto reductase family 1 member e2; 1,5-anhydro-D-fructose reductase; Catalyzes the NADPH-dependent reduction of 1,5-anhydro- D-fructose (AF) to 1,5-anhydro-D-glucitol (By similarity). Has low NADPH-dependent reductase activity towards 9,10- phenanthrenequinone (in vitro) (320 aa)    
Predicted Functional Partners:
ZPLD1
Zona pellucida-like domain-containing protein 1; Glycoprotein which is a component of the gelatinous extracellular matrix in the cupulae of the vestibular organ
      
 0.561
HS6ST3
Heparan-sulfate 6-O-sulfotransferase 3; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate; Sulfotransferases, membrane bound
      
 0.561
GALNTL6
Polypeptide N-acetylgalactosaminyltransferase-like 6; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor; Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily
      
 0.561
FAM162B
Protein FAM162B; Family with sequence similarity 162 member B
      
 0.557
ZNF776
Zinc finger protein 776; May be involved in transcriptional regulation; Zinc fingers C2H2-type
    
 
 0.513
CCSER1
Serine-rich coiled-coil domain-containing protein 1; Coiled-coil serine rich protein 1
      
 0.474
MFSD6L
Major facilitator superfamily domain-containing protein 6-like; Major facilitator superfamily domain containing 6 like
      
 0.459
THEG
Testicular haploid expressed gene protein; May be involved (but not essential) in spermatogenesis
      
 0.459
AKR7A3
Aflatoxin B1 aldehyde reductase member 3; Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen; Aldo-keto reductases
  
  
 0.435
KCNAB3
Voltage-gated potassium channel subunit beta-3; Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5; Aldo-keto reductases
  
  
 0.426
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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