node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRD13D | ATG16L2 | ENSP00000427130 | ENSP00000326340 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | Autophagy-related protein 16-2; May play a role in autophagy. | 0.515 |
ANKRD13D | FAM189A2 | ENSP00000427130 | ENSP00000304435 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | Protein FAM189A2; Family with sequence similarity 189 member A2. | 0.487 |
ANKRD13D | FAM189B | ENSP00000427130 | ENSP00000354958 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | Protein FAM189B; Family with sequence similarity 189 member B. | 0.494 |
ANKRD13D | FAM222A | ENSP00000427130 | ENSP00000443292 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | Protein FAM222A; Family with sequence similarity 222 member A; Belongs to the FAM222 family. | 0.464 |
ANKRD13D | LRRC73 | ENSP00000427130 | ENSP00000361518 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | Leucine-rich repeat-containing protein 73; Leucine rich repeat containing 73. | 0.665 |
ANKRD13D | POLR3H | ENSP00000427130 | ENSP00000347345 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | DNA-directed RNA polymerase III subunit RPC8; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Ep [...] | 0.473 |
ANKRD13D | SLC12A9 | ENSP00000427130 | ENSP00000275730 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | Solute carrier family 12 member 9; May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function. | 0.546 |
ANKRD13D | TEPSIN | ENSP00000427130 | ENSP00000490393 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | AP-4 complex accessory subunit Tepsin; Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. | 0.644 |
ANKRD13D | UBA52 | ENSP00000427130 | ENSP00000388107 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] | 0.797 |
ANKRD13D | VSIG10 | ENSP00000427130 | ENSP00000352172 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | V-set and immunoglobulin domain containing 10. | 0.558 |
ATG16L2 | ANKRD13D | ENSP00000326340 | ENSP00000427130 | Autophagy-related protein 16-2; May play a role in autophagy. | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | 0.515 |
FAM189A2 | ANKRD13D | ENSP00000304435 | ENSP00000427130 | Protein FAM189A2; Family with sequence similarity 189 member A2. | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | 0.487 |
FAM189A2 | FAM189B | ENSP00000304435 | ENSP00000354958 | Protein FAM189A2; Family with sequence similarity 189 member A2. | Protein FAM189B; Family with sequence similarity 189 member B. | 0.655 |
FAM189B | ANKRD13D | ENSP00000354958 | ENSP00000427130 | Protein FAM189B; Family with sequence similarity 189 member B. | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | 0.494 |
FAM189B | FAM189A2 | ENSP00000354958 | ENSP00000304435 | Protein FAM189B; Family with sequence similarity 189 member B. | Protein FAM189A2; Family with sequence similarity 189 member A2. | 0.655 |
FAM222A | ANKRD13D | ENSP00000443292 | ENSP00000427130 | Protein FAM222A; Family with sequence similarity 222 member A; Belongs to the FAM222 family. | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | 0.464 |
LRRC73 | ANKRD13D | ENSP00000361518 | ENSP00000427130 | Leucine-rich repeat-containing protein 73; Leucine rich repeat containing 73. | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | 0.665 |
LRRC73 | POLR3H | ENSP00000361518 | ENSP00000347345 | Leucine-rich repeat-containing protein 73; Leucine rich repeat containing 73. | DNA-directed RNA polymerase III subunit RPC8; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Ep [...] | 0.468 |
LRRC73 | TEPSIN | ENSP00000361518 | ENSP00000490393 | Leucine-rich repeat-containing protein 73; Leucine rich repeat containing 73. | AP-4 complex accessory subunit Tepsin; Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. | 0.625 |
LRRC73 | VSIG10 | ENSP00000361518 | ENSP00000352172 | Leucine-rich repeat-containing protein 73; Leucine rich repeat containing 73. | V-set and immunoglobulin domain containing 10. | 0.556 |