node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANAPC4 | ANKRD39 | ENSP00000426654 | ENSP00000377170 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. | Ankyrin repeat domain 39; Belongs to the ANKRD39 family. | 0.582 |
ANAPC4 | BABAM2 | ENSP00000426654 | ENSP00000343412 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. | BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...] | 0.900 |
ANAPC4 | BARD1 | ENSP00000426654 | ENSP00000260947 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. | BRCA1-associated RING domain protein 1; E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II [...] | 0.916 |
ANAPC4 | CDC27 | ENSP00000426654 | ENSP00000434614 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. | Cell division cycle protein 27 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC3/CDC27 family. | 0.999 |
ANAPC4 | UBE2S | ENSP00000426654 | ENSP00000264552 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. | Ubiquitin-conjugating enzyme E2 S; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiqui [...] | 0.992 |
ANKRD23 | ANKRD39 | ENSP00000321679 | ENSP00000377170 | Ankyrin repeat domain-containing protein 23; May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression. | Ankyrin repeat domain 39; Belongs to the ANKRD39 family. | 0.773 |
ANKRD23 | FAHD2B | ENSP00000321679 | ENSP00000410470 | Ankyrin repeat domain-containing protein 23; May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression. | Fumarylacetoacetate hydrolase domain-containing protein 2B; May have hydrolase activity. | 0.433 |
ANKRD23 | FAM178B | ENSP00000321679 | ENSP00000429896 | Ankyrin repeat domain-containing protein 23; May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression. | Protein FAM178B; Family with sequence similarity 178 member B. | 0.412 |
ANKRD36B | ANKRD39 | ENSP00000481149 | ENSP00000377170 | Ankyrin repeat domain 36B; Belongs to the ANKRD36 family. | Ankyrin repeat domain 39; Belongs to the ANKRD39 family. | 0.671 |
ANKRD36B | FAHD2B | ENSP00000481149 | ENSP00000410470 | Ankyrin repeat domain 36B; Belongs to the ANKRD36 family. | Fumarylacetoacetate hydrolase domain-containing protein 2B; May have hydrolase activity. | 0.476 |
ANKRD36B | FAM178B | ENSP00000481149 | ENSP00000429896 | Ankyrin repeat domain 36B; Belongs to the ANKRD36 family. | Protein FAM178B; Family with sequence similarity 178 member B. | 0.460 |
ANKRD39 | ANAPC4 | ENSP00000377170 | ENSP00000426654 | Ankyrin repeat domain 39; Belongs to the ANKRD39 family. | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. | 0.582 |
ANKRD39 | ANKRD23 | ENSP00000377170 | ENSP00000321679 | Ankyrin repeat domain 39; Belongs to the ANKRD39 family. | Ankyrin repeat domain-containing protein 23; May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression. | 0.773 |
ANKRD39 | ANKRD36B | ENSP00000377170 | ENSP00000481149 | Ankyrin repeat domain 39; Belongs to the ANKRD39 family. | Ankyrin repeat domain 36B; Belongs to the ANKRD36 family. | 0.671 |
ANKRD39 | BABAM2 | ENSP00000377170 | ENSP00000343412 | Ankyrin repeat domain 39; Belongs to the ANKRD39 family. | BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...] | 0.577 |
ANKRD39 | BARD1 | ENSP00000377170 | ENSP00000260947 | Ankyrin repeat domain 39; Belongs to the ANKRD39 family. | BRCA1-associated RING domain protein 1; E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II [...] | 0.581 |
ANKRD39 | CDC27 | ENSP00000377170 | ENSP00000434614 | Ankyrin repeat domain 39; Belongs to the ANKRD39 family. | Cell division cycle protein 27 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC3/CDC27 family. | 0.576 |
ANKRD39 | FAHD2B | ENSP00000377170 | ENSP00000410470 | Ankyrin repeat domain 39; Belongs to the ANKRD39 family. | Fumarylacetoacetate hydrolase domain-containing protein 2B; May have hydrolase activity. | 0.622 |
ANKRD39 | FAM178B | ENSP00000377170 | ENSP00000429896 | Ankyrin repeat domain 39; Belongs to the ANKRD39 family. | Protein FAM178B; Family with sequence similarity 178 member B. | 0.590 |
ANKRD39 | UBE2S | ENSP00000377170 | ENSP00000264552 | Ankyrin repeat domain 39; Belongs to the ANKRD39 family. | Ubiquitin-conjugating enzyme E2 S; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiqui [...] | 0.580 |