node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANO1 | ANO8 | ENSP00000347454 | ENSP00000159087 | Anoctamin-1; Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Belongs to the anoctamin family. | Anoctamin-8; Does not exhibit calcium-activated chloride channel (CaCC) activity. | 0.461 |
ANO1 | STIM1 | ENSP00000347454 | ENSP00000478059 | Anoctamin-1; Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Belongs to the anoctamin family. | Stromal interaction molecule 1; Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release- activated Ca(2+) (CRAC) channel subunit ORAI1. Involved in enamel formation. Activated following interaction with STIMATE, leading to promote STIM1 conformational switch. | 0.466 |
ANO5 | ANO8 | ENSP00000315371 | ENSP00000159087 | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity. | Anoctamin-8; Does not exhibit calcium-activated chloride channel (CaCC) activity. | 0.459 |
ANO8 | ANO1 | ENSP00000159087 | ENSP00000347454 | Anoctamin-8; Does not exhibit calcium-activated chloride channel (CaCC) activity. | Anoctamin-1; Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Belongs to the anoctamin family. | 0.461 |
ANO8 | ANO5 | ENSP00000159087 | ENSP00000315371 | Anoctamin-8; Does not exhibit calcium-activated chloride channel (CaCC) activity. | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity. | 0.459 |
ANO8 | ARL14EPL | ENSP00000159087 | ENSP00000472409 | Anoctamin-8; Does not exhibit calcium-activated chloride channel (CaCC) activity. | ARL14 effector protein-like; ADP ribosylation factor like GTPase 14 effector protein like. | 0.496 |
ANO8 | BTBD17 | ENSP00000159087 | ENSP00000364515 | Anoctamin-8; Does not exhibit calcium-activated chloride channel (CaCC) activity. | BTB/POZ domain-containing protein 17; BTB domain containing 17. | 0.519 |
ANO8 | C10orf71 | ENSP00000159087 | ENSP00000363259 | Anoctamin-8; Does not exhibit calcium-activated chloride channel (CaCC) activity. | Cardiac-enriched FHL2-interacting protein; Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. | 0.527 |
ANO8 | FAM20A | ENSP00000159087 | ENSP00000468308 | Anoctamin-8; Does not exhibit calcium-activated chloride channel (CaCC) activity. | Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals. | 0.484 |
ANO8 | FAM20C | ENSP00000159087 | ENSP00000322323 | Anoctamin-8; Does not exhibit calcium-activated chloride channel (CaCC) activity. | Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome. Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity. Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1. I [...] | 0.511 |
ANO8 | GFOD2 | ENSP00000159087 | ENSP00000268797 | Anoctamin-8; Does not exhibit calcium-activated chloride channel (CaCC) activity. | Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly. | 0.499 |
ANO8 | STIM1 | ENSP00000159087 | ENSP00000478059 | Anoctamin-8; Does not exhibit calcium-activated chloride channel (CaCC) activity. | Stromal interaction molecule 1; Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release- activated Ca(2+) (CRAC) channel subunit ORAI1. Involved in enamel formation. Activated following interaction with STIMATE, leading to promote STIM1 conformational switch. | 0.502 |
ANO8 | TBCCD1 | ENSP00000159087 | ENSP00000411253 | Anoctamin-8; Does not exhibit calcium-activated chloride channel (CaCC) activity. | TBCC domain-containing protein 1; Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration. | 0.499 |
ARL14EPL | ANO8 | ENSP00000472409 | ENSP00000159087 | ARL14 effector protein-like; ADP ribosylation factor like GTPase 14 effector protein like. | Anoctamin-8; Does not exhibit calcium-activated chloride channel (CaCC) activity. | 0.496 |
BTBD17 | ANO8 | ENSP00000364515 | ENSP00000159087 | BTB/POZ domain-containing protein 17; BTB domain containing 17. | Anoctamin-8; Does not exhibit calcium-activated chloride channel (CaCC) activity. | 0.519 |
C10orf71 | ANO8 | ENSP00000363259 | ENSP00000159087 | Cardiac-enriched FHL2-interacting protein; Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. | Anoctamin-8; Does not exhibit calcium-activated chloride channel (CaCC) activity. | 0.527 |
FAM20A | ANO8 | ENSP00000468308 | ENSP00000159087 | Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals. | Anoctamin-8; Does not exhibit calcium-activated chloride channel (CaCC) activity. | 0.484 |
FAM20A | FAM20C | ENSP00000468308 | ENSP00000322323 | Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals. | Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome. Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity. Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1. I [...] | 0.998 |
FAM20C | ANO8 | ENSP00000322323 | ENSP00000159087 | Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome. Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity. Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1. I [...] | Anoctamin-8; Does not exhibit calcium-activated chloride channel (CaCC) activity. | 0.511 |
FAM20C | FAM20A | ENSP00000322323 | ENSP00000468308 | Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome. Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity. Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1. I [...] | Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals. | 0.998 |