node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGAP4 | ARHGEF37 | ENSP00000359045 | ENSP00000328083 | Rho GTPase-activating protein 4; Inhibitory effect on stress fiber organization. May down- regulate Rho-like GTPase in hematopoietic cells. | Rho guanine nucleotide exchange factor 37; May act as a guanine nucleotide exchange factor (GEF). | 0.474 |
ARHGAP4 | FCHSD1 | ENSP00000359045 | ENSP00000399259 | Rho GTPase-activating protein 4; Inhibitory effect on stress fiber organization. May down- regulate Rho-like GTPase in hematopoietic cells. | F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL. | 0.576 |
ARHGAP4 | MTSS2 | ENSP00000359045 | ENSP00000341171 | Rho GTPase-activating protein 4; Inhibitory effect on stress fiber organization. May down- regulate Rho-like GTPase in hematopoietic cells. | Protein MTSS 2; Involved in plasma membrane dynamics. Potentiated PDGF- mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation. May function in actin bundling ; Belongs to the MTSS family. | 0.415 |
ARHGAP4 | RHOA | ENSP00000359045 | ENSP00000400175 | Rho GTPase-activating protein 4; Inhibitory effect on stress fiber organization. May down- regulate Rho-like GTPase in hematopoietic cells. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.563 |
ARHGAP44 | ARHGEF37 | ENSP00000368994 | ENSP00000328083 | Rho GTPase-activating protein 44; GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1. In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (By similarity). Limits the initiation of exploratory dendritic filopodia. Recruited to actin- patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin m [...] | Rho guanine nucleotide exchange factor 37; May act as a guanine nucleotide exchange factor (GEF). | 0.495 |
ARHGAP44 | FCHSD1 | ENSP00000368994 | ENSP00000399259 | Rho GTPase-activating protein 44; GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1. In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (By similarity). Limits the initiation of exploratory dendritic filopodia. Recruited to actin- patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin m [...] | F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL. | 0.437 |
ARHGAP44 | RHOA | ENSP00000368994 | ENSP00000400175 | Rho GTPase-activating protein 44; GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1. In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (By similarity). Limits the initiation of exploratory dendritic filopodia. Recruited to actin- patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin m [...] | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.517 |
ARHGEF1 | ARHGEF35 | ENSP00000337261 | ENSP00000367355 | Rho guanine nucleotide exchange factor 1; Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation. | Rho guanine nucleotide exchange factor 35. | 0.509 |
ARHGEF1 | ARHGEF37 | ENSP00000337261 | ENSP00000328083 | Rho guanine nucleotide exchange factor 1; Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation. | Rho guanine nucleotide exchange factor 37; May act as a guanine nucleotide exchange factor (GEF). | 0.490 |
ARHGEF1 | ARHGEF39 | ENSP00000337261 | ENSP00000367638 | Rho guanine nucleotide exchange factor 1; Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation. | Rho guanine nucleotide exchange factor 39; Promotes cell proliferation. | 0.438 |
ARHGEF1 | RHOA | ENSP00000337261 | ENSP00000400175 | Rho guanine nucleotide exchange factor 1; Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.997 |
ARHGEF1 | RHOB | ENSP00000337261 | ENSP00000272233 | Rho guanine nucleotide exchange factor 1; Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation. | Rho-related GTP-binding protein RhoB; Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascul [...] | 0.901 |
ARHGEF35 | ARHGEF1 | ENSP00000367355 | ENSP00000337261 | Rho guanine nucleotide exchange factor 35. | Rho guanine nucleotide exchange factor 1; Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation. | 0.509 |
ARHGEF35 | ARHGEF37 | ENSP00000367355 | ENSP00000328083 | Rho guanine nucleotide exchange factor 35. | Rho guanine nucleotide exchange factor 37; May act as a guanine nucleotide exchange factor (GEF). | 0.521 |
ARHGEF35 | RHOA | ENSP00000367355 | ENSP00000400175 | Rho guanine nucleotide exchange factor 35. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.406 |
ARHGEF35 | RHOB | ENSP00000367355 | ENSP00000272233 | Rho guanine nucleotide exchange factor 35. | Rho-related GTP-binding protein RhoB; Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascul [...] | 0.400 |
ARHGEF37 | ARHGAP4 | ENSP00000328083 | ENSP00000359045 | Rho guanine nucleotide exchange factor 37; May act as a guanine nucleotide exchange factor (GEF). | Rho GTPase-activating protein 4; Inhibitory effect on stress fiber organization. May down- regulate Rho-like GTPase in hematopoietic cells. | 0.474 |
ARHGEF37 | ARHGAP44 | ENSP00000328083 | ENSP00000368994 | Rho guanine nucleotide exchange factor 37; May act as a guanine nucleotide exchange factor (GEF). | Rho GTPase-activating protein 44; GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1. In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (By similarity). Limits the initiation of exploratory dendritic filopodia. Recruited to actin- patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin m [...] | 0.495 |
ARHGEF37 | ARHGEF1 | ENSP00000328083 | ENSP00000337261 | Rho guanine nucleotide exchange factor 37; May act as a guanine nucleotide exchange factor (GEF). | Rho guanine nucleotide exchange factor 1; Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation. | 0.490 |
ARHGEF37 | ARHGEF35 | ENSP00000328083 | ENSP00000367355 | Rho guanine nucleotide exchange factor 37; May act as a guanine nucleotide exchange factor (GEF). | Rho guanine nucleotide exchange factor 35. | 0.521 |