node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATXN2 | ATXN2L | ENSP00000446576 | ENSP00000378917 | Ataxin-2; Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. | Ataxin-2-like protein; Involved in the regulation of stress granule and P-body formation. | 0.953 |
ATXN2 | ATXN3 | ENSP00000446576 | ENSP00000496695 | Ataxin-2; Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. | Ataxin-3; Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins. Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key [...] | 0.993 |
ATXN2 | ATXN3L | ENSP00000446576 | ENSP00000369996 | Ataxin-2; Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. | Ataxin-3-like protein; Deubiquitinating enzyme that cleaves both 'Lys-48'-linked and 'Lys-63'-linked poly-ubiquitin chains (in vitro). | 0.961 |
ATXN2 | DDX6 | ENSP00000446576 | ENSP00000478754 | Ataxin-2; Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. | Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts. Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. | 0.993 |
ATXN2 | ITPR1 | ENSP00000446576 | ENSP00000306253 | Ataxin-2; Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. | Inositol 1,4,5-trisphosphate receptor type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). | 0.996 |
ATXN2 | ITPR2 | ENSP00000446576 | ENSP00000370744 | Ataxin-2; Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. | Inositol 1,4,5-trisphosphate receptor type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity). | 0.916 |
ATXN2 | ITPR3 | ENSP00000446576 | ENSP00000363435 | Ataxin-2; Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. | Inositol 1,4,5-trisphosphate receptor type 3; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. | 0.913 |
ATXN2 | LSM12 | ENSP00000446576 | ENSP00000466718 | Ataxin-2; Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. | LSM12 homolog. | 0.985 |
ATXN2 | NUFIP2 | ENSP00000446576 | ENSP00000225388 | Ataxin-2; Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. | Nuclear fragile X mental retardation-interacting protein 2; Binds RNA. | 0.816 |
ATXN2 | PABPC1 | ENSP00000446576 | ENSP00000313007 | Ataxin-2; Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. | Polyadenylate-binding protein 1; Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region deter [...] | 0.998 |
ATXN2L | ATXN2 | ENSP00000378917 | ENSP00000446576 | Ataxin-2-like protein; Involved in the regulation of stress granule and P-body formation. | Ataxin-2; Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. | 0.953 |
ATXN2L | ATXN3 | ENSP00000378917 | ENSP00000496695 | Ataxin-2-like protein; Involved in the regulation of stress granule and P-body formation. | Ataxin-3; Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins. Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key [...] | 0.917 |
ATXN2L | ATXN3L | ENSP00000378917 | ENSP00000369996 | Ataxin-2-like protein; Involved in the regulation of stress granule and P-body formation. | Ataxin-3-like protein; Deubiquitinating enzyme that cleaves both 'Lys-48'-linked and 'Lys-63'-linked poly-ubiquitin chains (in vitro). | 0.903 |
ATXN2L | DDX6 | ENSP00000378917 | ENSP00000478754 | Ataxin-2-like protein; Involved in the regulation of stress granule and P-body formation. | Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts. Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. | 0.952 |
ATXN2L | ITPR1 | ENSP00000378917 | ENSP00000306253 | Ataxin-2-like protein; Involved in the regulation of stress granule and P-body formation. | Inositol 1,4,5-trisphosphate receptor type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). | 0.900 |
ATXN2L | ITPR2 | ENSP00000378917 | ENSP00000370744 | Ataxin-2-like protein; Involved in the regulation of stress granule and P-body formation. | Inositol 1,4,5-trisphosphate receptor type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity). | 0.900 |
ATXN2L | ITPR3 | ENSP00000378917 | ENSP00000363435 | Ataxin-2-like protein; Involved in the regulation of stress granule and P-body formation. | Inositol 1,4,5-trisphosphate receptor type 3; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. | 0.908 |
ATXN2L | LSM12 | ENSP00000378917 | ENSP00000466718 | Ataxin-2-like protein; Involved in the regulation of stress granule and P-body formation. | LSM12 homolog. | 0.986 |
ATXN2L | NUFIP2 | ENSP00000378917 | ENSP00000225388 | Ataxin-2-like protein; Involved in the regulation of stress granule and P-body formation. | Nuclear fragile X mental retardation-interacting protein 2; Binds RNA. | 0.906 |
ATXN2L | PABPC1 | ENSP00000378917 | ENSP00000313007 | Ataxin-2-like protein; Involved in the regulation of stress granule and P-body formation. | Polyadenylate-binding protein 1; Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region deter [...] | 0.917 |