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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AURKAIP1Aurora kinase A-interacting protein; May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation (199 aa)    
Predicted Functional Partners:
MRPS31
28S ribosomal protein S31, mitochondrial; Mitochondrial ribosomal protein S31
   
 0.992
MRPS11
28S ribosomal protein S11, mitochondrial; Mitochondrial ribosomal protein S11
   
 0.991
CHCHD1
Coiled-coil-helix-coiled-coil-helix domain-containing protein 1; Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins
   
 0.991
MRPS27
28S ribosomal protein S27, mitochondrial; RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis. Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain. Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu). Involved also in positive regulation of cell proliferation and tumor cell growth
   
 0.988
MRPS21
Mitochondrial ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family
   
 0.987
AURKA
Aurora kinase A; Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDE [...]
    
 0.983
MRPS2
28S ribosomal protein S2, mitochondrial; Mitochondrial ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family
   
  0.983
MRPS7
28S ribosomal protein S7, mitochondrial; Mitochondrial ribosomal protein S7; Belongs to the universal ribosomal protein uS7 family
   
 0.982
MRPS10
28S ribosomal protein S10, mitochondrial; Mitochondrial ribosomal protein S10; Belongs to the universal ribosomal protein uS10 family
   
 0.981
PTCD3
Pentatricopeptide repeat domain-containing protein 3, mitochondrial; Mitochondrial RNA-binding protein that has a role in mitochondrial translation
   
 0.981
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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