node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C11orf16 | C11orf42 | ENSP00000318999 | ENSP00000321021 | Uncharacterized protein C11orf16; Chromosome 11 open reading frame 16. | Uncharacterized protein C11orf42; Chromosome 11 open reading frame 42. | 0.454 |
C11orf42 | C11orf16 | ENSP00000321021 | ENSP00000318999 | Uncharacterized protein C11orf42; Chromosome 11 open reading frame 42. | Uncharacterized protein C11orf16; Chromosome 11 open reading frame 16. | 0.454 |
C11orf42 | DKKL1 | ENSP00000321021 | ENSP00000221498 | Uncharacterized protein C11orf42; Chromosome 11 open reading frame 42. | Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility. | 0.444 |
C11orf42 | FAM71F1 | ENSP00000321021 | ENSP00000326652 | Uncharacterized protein C11orf42; Chromosome 11 open reading frame 42. | Protein FAM71F1; Family with sequence similarity 71 member F1. | 0.468 |
C11orf42 | GALNTL5 | ENSP00000321021 | ENSP00000479207 | Uncharacterized protein C11orf42; Chromosome 11 open reading frame 42. | Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5; Probable inactive glycosyltransferase required during spermatid development. May participate in protein loading into the acrosomes and accumulation of ubiquitin-proteasome systems around the head-tail coupling apparatus region. | 0.416 |
C11orf42 | IL22RA1 | ENSP00000321021 | ENSP00000270800 | Uncharacterized protein C11orf42; Chromosome 11 open reading frame 42. | Interleukin-22 receptor subunit alpha-1; Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. | 0.424 |
C11orf42 | LRRC36 | ENSP00000321021 | ENSP00000329943 | Uncharacterized protein C11orf42; Chromosome 11 open reading frame 42. | Leucine-rich repeat-containing protein 36; Leucine rich repeat containing 36. | 0.434 |
C11orf42 | PDCL2 | ENSP00000321021 | ENSP00000295645 | Uncharacterized protein C11orf42; Chromosome 11 open reading frame 42. | Phosducin-like protein 2; May play a role in germ cell maturation; Belongs to the phosducin family. | 0.507 |
C11orf42 | SNX2 | ENSP00000321021 | ENSP00000368831 | Uncharacterized protein C11orf42; Chromosome 11 open reading frame 42. | Sorting nexin-2; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane- deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called e [...] | 0.459 |
C11orf42 | SNX5 | ENSP00000321021 | ENSP00000366998 | Uncharacterized protein C11orf42; Chromosome 11 open reading frame 42. | Sorting nexin-5; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). Acts in part as component of the retromer membrane- deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called e [...] | 0.636 |
C11orf42 | SPESP1 | ENSP00000321021 | ENSP00000312284 | Uncharacterized protein C11orf42; Chromosome 11 open reading frame 42. | Sperm equatorial segment protein 1; Involved in fertilization ability of sperm. Belongs to the SPESP1 family. | 0.447 |
DKKL1 | C11orf42 | ENSP00000221498 | ENSP00000321021 | Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility. | Uncharacterized protein C11orf42; Chromosome 11 open reading frame 42. | 0.444 |
DKKL1 | FAM71F1 | ENSP00000221498 | ENSP00000326652 | Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility. | Protein FAM71F1; Family with sequence similarity 71 member F1. | 0.422 |
DKKL1 | IL22RA1 | ENSP00000221498 | ENSP00000270800 | Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility. | Interleukin-22 receptor subunit alpha-1; Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. | 0.439 |
FAM71F1 | C11orf42 | ENSP00000326652 | ENSP00000321021 | Protein FAM71F1; Family with sequence similarity 71 member F1. | Uncharacterized protein C11orf42; Chromosome 11 open reading frame 42. | 0.468 |
FAM71F1 | DKKL1 | ENSP00000326652 | ENSP00000221498 | Protein FAM71F1; Family with sequence similarity 71 member F1. | Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility. | 0.422 |
GALNTL5 | C11orf42 | ENSP00000479207 | ENSP00000321021 | Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5; Probable inactive glycosyltransferase required during spermatid development. May participate in protein loading into the acrosomes and accumulation of ubiquitin-proteasome systems around the head-tail coupling apparatus region. | Uncharacterized protein C11orf42; Chromosome 11 open reading frame 42. | 0.416 |
IL22RA1 | C11orf42 | ENSP00000270800 | ENSP00000321021 | Interleukin-22 receptor subunit alpha-1; Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. | Uncharacterized protein C11orf42; Chromosome 11 open reading frame 42. | 0.424 |
IL22RA1 | DKKL1 | ENSP00000270800 | ENSP00000221498 | Interleukin-22 receptor subunit alpha-1; Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. | Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility. | 0.439 |
LRRC36 | C11orf42 | ENSP00000329943 | ENSP00000321021 | Leucine-rich repeat-containing protein 36; Leucine rich repeat containing 36. | Uncharacterized protein C11orf42; Chromosome 11 open reading frame 42. | 0.434 |