node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BOD1L1 | C1orf159 | ENSP00000040738 | ENSP00000368644 | Biorientation of chromosomes in cell division protein 1-like 1; Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2- dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM. Does not regulate spindle orientation ; Belongs to the BOD1 family. | Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159. | 0.498 |
BOD1L1 | DNHD1 | ENSP00000040738 | ENSP00000254579 | Biorientation of chromosomes in cell division protein 1-like 1; Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2- dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM. Does not regulate spindle orientation ; Belongs to the BOD1 family. | Dynein heavy chain domain 1. | 0.466 |
BOD1L1 | FRMD8 | ENSP00000040738 | ENSP00000319726 | Biorientation of chromosomes in cell division protein 1-like 1; Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2- dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM. Does not regulate spindle orientation ; Belongs to the BOD1 family. | FERM domain-containing protein 8; Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface. Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6. | 0.442 |
BOD1L1 | FRRS1L | ENSP00000040738 | ENSP00000477141 | Biorientation of chromosomes in cell division protein 1-like 1; Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2- dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM. Does not regulate spindle orientation ; Belongs to the BOD1 family. | DOMON domain-containing protein FRRS1L; Important modulator of glutamate signaling pathway. | 0.433 |
BOD1L1 | PTCD2 | ENSP00000040738 | ENSP00000370013 | Biorientation of chromosomes in cell division protein 1-like 1; Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2- dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM. Does not regulate spindle orientation ; Belongs to the BOD1 family. | Pentatricopeptide repeat-containing protein 2, mitochondrial; Involved in mitochondrial RNA maturation and mitochondrial respiratory chain function. | 0.453 |
BOD1L1 | SSH2 | ENSP00000040738 | ENSP00000444743 | Biorientation of chromosomes in cell division protein 1-like 1; Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2- dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM. Does not regulate spindle orientation ; Belongs to the BOD1 family. | Protein phosphatase Slingshot homolog 2; Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. | 0.481 |
BOD1L1 | ZNF106 | ENSP00000040738 | ENSP00000263805 | Biorientation of chromosomes in cell division protein 1-like 1; Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2- dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM. Does not regulate spindle orientation ; Belongs to the BOD1 family. | Zinc finger protein 106; RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. | 0.489 |
BOD1L1 | ZNHIT2 | ENSP00000040738 | ENSP00000308548 | Biorientation of chromosomes in cell division protein 1-like 1; Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2- dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM. Does not regulate spindle orientation ; Belongs to the BOD1 family. | Zinc finger HIT domain-containing protein 2; May act as a bridging factor mediating the interaction between the R2TP/Prefoldin-like (R2TP/PFDL) complex and U5 small nuclear ribonucleoprotein (U5 snRNP). Required for the interaction of R2TP complex subunit RPAP3 and prefoldin-like subunit URI1 with U5 snRNP proteins EFTUD2 and PRPF8. May play a role in regulating the composition of the U5 snRNP complex. | 0.447 |
C1orf159 | BOD1L1 | ENSP00000368644 | ENSP00000040738 | Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159. | Biorientation of chromosomes in cell division protein 1-like 1; Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2- dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM. Does not regulate spindle orientation ; Belongs to the BOD1 family. | 0.498 |
C1orf159 | COG1 | ENSP00000368644 | ENSP00000299886 | Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159. | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | 0.474 |
C1orf159 | DNHD1 | ENSP00000368644 | ENSP00000254579 | Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159. | Dynein heavy chain domain 1. | 0.540 |
C1orf159 | FRMD8 | ENSP00000368644 | ENSP00000319726 | Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159. | FERM domain-containing protein 8; Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface. Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6. | 0.510 |
C1orf159 | FRRS1L | ENSP00000368644 | ENSP00000477141 | Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159. | DOMON domain-containing protein FRRS1L; Important modulator of glutamate signaling pathway. | 0.494 |
C1orf159 | PTCD2 | ENSP00000368644 | ENSP00000370013 | Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159. | Pentatricopeptide repeat-containing protein 2, mitochondrial; Involved in mitochondrial RNA maturation and mitochondrial respiratory chain function. | 0.527 |
C1orf159 | SSH2 | ENSP00000368644 | ENSP00000444743 | Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159. | Protein phosphatase Slingshot homolog 2; Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. | 0.470 |
C1orf159 | TRAF2 | ENSP00000368644 | ENSP00000247668 | Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159. | TNF receptor-associated factor 2; Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels [...] | 0.470 |
C1orf159 | ZNF106 | ENSP00000368644 | ENSP00000263805 | Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159. | Zinc finger protein 106; RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. | 0.506 |
C1orf159 | ZNHIT2 | ENSP00000368644 | ENSP00000308548 | Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159. | Zinc finger HIT domain-containing protein 2; May act as a bridging factor mediating the interaction between the R2TP/Prefoldin-like (R2TP/PFDL) complex and U5 small nuclear ribonucleoprotein (U5 snRNP). Required for the interaction of R2TP complex subunit RPAP3 and prefoldin-like subunit URI1 with U5 snRNP proteins EFTUD2 and PRPF8. May play a role in regulating the composition of the U5 snRNP complex. | 0.536 |
COG1 | C1orf159 | ENSP00000299886 | ENSP00000368644 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159. | 0.474 |
DNHD1 | BOD1L1 | ENSP00000254579 | ENSP00000040738 | Dynein heavy chain domain 1. | Biorientation of chromosomes in cell division protein 1-like 1; Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2- dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM. Does not regulate spindle orientation ; Belongs to the BOD1 family. | 0.466 |