node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C1orf189 | C1orf43 | ENSP00000357511 | ENSP00000357507 | Uncharacterized protein C1orf189; Chromosome 1 open reading frame 189. | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43. | 0.550 |
C1orf43 | C1orf189 | ENSP00000357507 | ENSP00000357511 | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43. | Uncharacterized protein C1orf189; Chromosome 1 open reading frame 189. | 0.550 |
C1orf43 | CHMP2A | ENSP00000357507 | ENSP00000469240 | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43. | Charged multivesicular body protein 2a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | 0.658 |
C1orf43 | CRCT1 | ENSP00000357507 | ENSP00000357779 | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43. | Cysteine rich C-terminal 1. | 0.657 |
C1orf43 | EMC7 | ENSP00000357507 | ENSP00000256545 | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43. | ER membrane protein complex subunit 7; Belongs to the EMC7 family. | 0.825 |
C1orf43 | KIAA1109 | ENSP00000357507 | ENSP00000264501 | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43. | Transmembrane protein KIAA1109; KIAA1109. | 0.561 |
C1orf43 | MRFAP1 | ENSP00000357507 | ENSP00000318352 | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43. | Morf4 family associated protein 1. | 0.542 |
C1orf43 | PSMB2 | ENSP00000357507 | ENSP00000362334 | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43. | Proteasome subunit beta type-2; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] | 0.591 |
C1orf43 | PSMB4 | ENSP00000357507 | ENSP00000290541 | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43. | Proteasome subunit beta type-4; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] | 0.633 |
C1orf43 | S100A7A | ENSP00000357507 | ENSP00000357718 | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43. | Protein S100-A7A; May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases. | 0.581 |
C1orf43 | VPS29 | ENSP00000357507 | ENSP00000480853 | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43. | Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans- Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for carg [...] | 0.546 |
CHMP2A | C1orf43 | ENSP00000469240 | ENSP00000357507 | Charged multivesicular body protein 2a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43. | 0.658 |
CHMP2A | EMC7 | ENSP00000469240 | ENSP00000256545 | Charged multivesicular body protein 2a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | ER membrane protein complex subunit 7; Belongs to the EMC7 family. | 0.724 |
CHMP2A | PSMB2 | ENSP00000469240 | ENSP00000362334 | Charged multivesicular body protein 2a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | Proteasome subunit beta type-2; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] | 0.490 |
CHMP2A | PSMB4 | ENSP00000469240 | ENSP00000290541 | Charged multivesicular body protein 2a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | Proteasome subunit beta type-4; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] | 0.496 |
CHMP2A | VPS29 | ENSP00000469240 | ENSP00000480853 | Charged multivesicular body protein 2a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans- Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for carg [...] | 0.605 |
CRCT1 | C1orf43 | ENSP00000357779 | ENSP00000357507 | Cysteine rich C-terminal 1. | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43. | 0.657 |
CRCT1 | S100A7A | ENSP00000357779 | ENSP00000357718 | Cysteine rich C-terminal 1. | Protein S100-A7A; May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases. | 0.646 |
EMC7 | C1orf43 | ENSP00000256545 | ENSP00000357507 | ER membrane protein complex subunit 7; Belongs to the EMC7 family. | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43. | 0.825 |
EMC7 | CHMP2A | ENSP00000256545 | ENSP00000469240 | ER membrane protein complex subunit 7; Belongs to the EMC7 family. | Charged multivesicular body protein 2a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | 0.724 |