node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BBOF1 | C1orf74 | ENSP00000377577 | ENSP00000294811 | Basal body-orientation factor 1; Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues (By similarity); Belongs to the BBOF1 family. | UPF0739 protein C1orf74; Chromosome 1 open reading frame 74; Belongs to the UPF0739 family. | 0.479 |
C1orf74 | BBOF1 | ENSP00000294811 | ENSP00000377577 | UPF0739 protein C1orf74; Chromosome 1 open reading frame 74; Belongs to the UPF0739 family. | Basal body-orientation factor 1; Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues (By similarity); Belongs to the BBOF1 family. | 0.479 |
C1orf74 | CWF19L1 | ENSP00000294811 | ENSP00000326411 | UPF0739 protein C1orf74; Chromosome 1 open reading frame 74; Belongs to the UPF0739 family. | CWF19-like protein 1; CWF19 like cell cycle control factor 1. | 0.564 |
C1orf74 | NREP | ENSP00000294811 | ENSP00000378996 | UPF0739 protein C1orf74; Chromosome 1 open reading frame 74; Belongs to the UPF0739 family. | Neuronal regeneration-related protein; May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation. | 0.494 |
C1orf74 | NUP155 | ENSP00000294811 | ENSP00000231498 | UPF0739 protein C1orf74; Chromosome 1 open reading frame 74; Belongs to the UPF0739 family. | Nuclear pore complex protein Nup155; Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. | 0.440 |
C1orf74 | RFC5 | ENSP00000294811 | ENSP00000408295 | UPF0739 protein C1orf74; Chromosome 1 open reading frame 74; Belongs to the UPF0739 family. | Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. | 0.463 |
C1orf74 | RHEX | ENSP00000294811 | ENSP00000356093 | UPF0739 protein C1orf74; Chromosome 1 open reading frame 74; Belongs to the UPF0739 family. | Regulator of hemoglobinization and erythroid cell expansion protein; Acts as a signaling transduction factor of the EPO-EPOR signaling pathway promoting erythroid cell differentiation. | 0.446 |
C1orf74 | TRAF3IP3 | ENSP00000294811 | ENSP00000355991 | UPF0739 protein C1orf74; Chromosome 1 open reading frame 74; Belongs to the UPF0739 family. | TRAF3-interacting JNK-activating modulator; May function as an adapter molecule that regulates TRAF3- mediated JNK activation. | 0.544 |
C1orf74 | USP33 | ENSP00000294811 | ENSP00000359829 | UPF0739 protein C1orf74; Chromosome 1 open reading frame 74; Belongs to the UPF0739 family. | Ubiquitin carboxyl-terminal hydrolase 33; Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the ne [...] | 0.418 |
C1orf74 | USP54 | ENSP00000294811 | ENSP00000345216 | UPF0739 protein C1orf74; Chromosome 1 open reading frame 74; Belongs to the UPF0739 family. | Inactive ubiquitin carboxyl-terminal hydrolase 54; Has no peptidase activity; Belongs to the peptidase C19 family. | 0.516 |
C1orf74 | UTP25 | ENSP00000294811 | ENSP00000419005 | UPF0739 protein C1orf74; Chromosome 1 open reading frame 74; Belongs to the UPF0739 family. | Digestive organ expansion factor homolog; Regulates the p53 pathway to control the expansion growth of digestive organs. | 0.518 |
CWF19L1 | C1orf74 | ENSP00000326411 | ENSP00000294811 | CWF19-like protein 1; CWF19 like cell cycle control factor 1. | UPF0739 protein C1orf74; Chromosome 1 open reading frame 74; Belongs to the UPF0739 family. | 0.564 |
CWF19L1 | USP54 | ENSP00000326411 | ENSP00000345216 | CWF19-like protein 1; CWF19 like cell cycle control factor 1. | Inactive ubiquitin carboxyl-terminal hydrolase 54; Has no peptidase activity; Belongs to the peptidase C19 family. | 0.424 |
NREP | C1orf74 | ENSP00000378996 | ENSP00000294811 | Neuronal regeneration-related protein; May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation. | UPF0739 protein C1orf74; Chromosome 1 open reading frame 74; Belongs to the UPF0739 family. | 0.494 |
NUP155 | C1orf74 | ENSP00000231498 | ENSP00000294811 | Nuclear pore complex protein Nup155; Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. | UPF0739 protein C1orf74; Chromosome 1 open reading frame 74; Belongs to the UPF0739 family. | 0.440 |
NUP155 | RFC5 | ENSP00000231498 | ENSP00000408295 | Nuclear pore complex protein Nup155; Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. | Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. | 0.480 |
RFC5 | C1orf74 | ENSP00000408295 | ENSP00000294811 | Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. | UPF0739 protein C1orf74; Chromosome 1 open reading frame 74; Belongs to the UPF0739 family. | 0.463 |
RFC5 | NUP155 | ENSP00000408295 | ENSP00000231498 | Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. | Nuclear pore complex protein Nup155; Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. | 0.480 |
RHEX | C1orf74 | ENSP00000356093 | ENSP00000294811 | Regulator of hemoglobinization and erythroid cell expansion protein; Acts as a signaling transduction factor of the EPO-EPOR signaling pathway promoting erythroid cell differentiation. | UPF0739 protein C1orf74; Chromosome 1 open reading frame 74; Belongs to the UPF0739 family. | 0.446 |
TRAF3IP3 | C1orf74 | ENSP00000355991 | ENSP00000294811 | TRAF3-interacting JNK-activating modulator; May function as an adapter molecule that regulates TRAF3- mediated JNK activation. | UPF0739 protein C1orf74; Chromosome 1 open reading frame 74; Belongs to the UPF0739 family. | 0.544 |