node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRD13C | C5orf24 | ENSP00000359982 | ENSP00000378427 | Ankyrin repeat domain-containing protein 13C; Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER. | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family. | 0.428 |
C5orf24 | ANKRD13C | ENSP00000378427 | ENSP00000359982 | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family. | Ankyrin repeat domain-containing protein 13C; Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER. | 0.428 |
C5orf24 | CAB39 | ENSP00000378427 | ENSP00000258418 | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family. | Calcium-binding protein 39; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1. | 0.491 |
C5orf24 | CATSPER3 | ENSP00000378427 | ENSP00000282611 | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family. | Cation channel sperm-associated protein 3; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. | 0.447 |
C5orf24 | LSMEM2 | ENSP00000378427 | ENSP00000315081 | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family. | Leucine rich single-pass membrane protein 2. | 0.506 |
C5orf24 | PBX1 | ENSP00000378427 | ENSP00000405890 | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family. | Pre-B-cell leukemia transcription factor 1; Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhanc [...] | 0.420 |
C5orf24 | PKNOX1 | ENSP00000378427 | ENSP00000291547 | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family. | Homeobox protein PKNOX1; Activates transcription in the presence of PBX1A and HOXA1. | 0.431 |
C5orf24 | PKNOX2 | ENSP00000378427 | ENSP00000298282 | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family. | Homeobox protein PKNOX2; PBX/knotted 1 homeobox 2; Belongs to the TALE/MEIS homeobox family. | 0.591 |
C5orf24 | STK11 | ENSP00000378427 | ENSP00000324856 | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family. | Serine/threonine-protein kinase STK11; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP [...] | 0.422 |
C5orf24 | STRADA | ENSP00000378427 | ENSP00000336655 | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family. | STE20-related kinase adapter protein alpha; Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. | 0.685 |
C5orf24 | ZNF551 | ENSP00000378427 | ENSP00000282296 | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family. | Zinc finger protein 551; May be involved in transcriptional regulation. | 0.431 |
CAB39 | C5orf24 | ENSP00000258418 | ENSP00000378427 | Calcium-binding protein 39; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1. | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family. | 0.491 |
CAB39 | STK11 | ENSP00000258418 | ENSP00000324856 | Calcium-binding protein 39; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1. | Serine/threonine-protein kinase STK11; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP [...] | 0.999 |
CAB39 | STRADA | ENSP00000258418 | ENSP00000336655 | Calcium-binding protein 39; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1. | STE20-related kinase adapter protein alpha; Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. | 0.999 |
CATSPER3 | C5orf24 | ENSP00000282611 | ENSP00000378427 | Cation channel sperm-associated protein 3; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family. | 0.447 |
LSMEM2 | C5orf24 | ENSP00000315081 | ENSP00000378427 | Leucine rich single-pass membrane protein 2. | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family. | 0.506 |
LSMEM2 | ZNF551 | ENSP00000315081 | ENSP00000282296 | Leucine rich single-pass membrane protein 2. | Zinc finger protein 551; May be involved in transcriptional regulation. | 0.505 |
PBX1 | C5orf24 | ENSP00000405890 | ENSP00000378427 | Pre-B-cell leukemia transcription factor 1; Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhanc [...] | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family. | 0.420 |
PBX1 | PKNOX1 | ENSP00000405890 | ENSP00000291547 | Pre-B-cell leukemia transcription factor 1; Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhanc [...] | Homeobox protein PKNOX1; Activates transcription in the presence of PBX1A and HOXA1. | 0.999 |
PBX1 | PKNOX2 | ENSP00000405890 | ENSP00000298282 | Pre-B-cell leukemia transcription factor 1; Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhanc [...] | Homeobox protein PKNOX2; PBX/knotted 1 homeobox 2; Belongs to the TALE/MEIS homeobox family. | 0.917 |