node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP2B1 | CABCOCO1 | ENSP00000392043 | ENSP00000328698 | Plasma membrane calcium-transporting ATPase 1; Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-ind [...] | Ciliary-associated calcium-binding coiled-coil protein 1; Calcium-binding protein. May be involved in the control of sperm flagellar movement. | 0.513 |
ATP2B1 | CACNB2 | ENSP00000392043 | ENSP00000320025 | Plasma membrane calcium-transporting ATPase 1; Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-ind [...] | Voltage-dependent L-type calcium channel subunit beta-2; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. | 0.454 |
ATP2B1 | PLCD3 | ENSP00000392043 | ENSP00000479636 | Plasma membrane calcium-transporting ATPase 1; Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-ind [...] | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow. | 0.438 |
ATP2B1 | PLEKHA7 | ENSP00000392043 | ENSP00000435389 | Plasma membrane calcium-transporting ATPase 1; Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-ind [...] | Pleckstrin homology domain-containing family A member 7; Required for zonula adherens biogenesis and maintenance. Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site. Mediates docking of ADAM10 to zonula adherens through a PDZD11- dependent interaction with the ADAM10-binding protein TSPAN33. | 0.477 |
C4orf47 | C5orf49 | ENSP00000368127 | ENSP00000382708 | UPF0602 protein C4orf47; Chromosome 4 open reading frame 47; Belongs to the UPF0602 family. | Uncharacterized protein C5orf49; Chromosome 5 open reading frame 49. | 0.677 |
C4orf47 | CABCOCO1 | ENSP00000368127 | ENSP00000328698 | UPF0602 protein C4orf47; Chromosome 4 open reading frame 47; Belongs to the UPF0602 family. | Ciliary-associated calcium-binding coiled-coil protein 1; Calcium-binding protein. May be involved in the control of sperm flagellar movement. | 0.502 |
C4orf47 | CCDC96 | ENSP00000368127 | ENSP00000309285 | UPF0602 protein C4orf47; Chromosome 4 open reading frame 47; Belongs to the UPF0602 family. | Coiled-coil domain containing 96. | 0.776 |
C5orf49 | C4orf47 | ENSP00000382708 | ENSP00000368127 | Uncharacterized protein C5orf49; Chromosome 5 open reading frame 49. | UPF0602 protein C4orf47; Chromosome 4 open reading frame 47; Belongs to the UPF0602 family. | 0.677 |
C5orf49 | CABCOCO1 | ENSP00000382708 | ENSP00000328698 | Uncharacterized protein C5orf49; Chromosome 5 open reading frame 49. | Ciliary-associated calcium-binding coiled-coil protein 1; Calcium-binding protein. May be involved in the control of sperm flagellar movement. | 0.621 |
C5orf49 | CCDC96 | ENSP00000382708 | ENSP00000309285 | Uncharacterized protein C5orf49; Chromosome 5 open reading frame 49. | Coiled-coil domain containing 96. | 0.571 |
CABCOCO1 | ATP2B1 | ENSP00000328698 | ENSP00000392043 | Ciliary-associated calcium-binding coiled-coil protein 1; Calcium-binding protein. May be involved in the control of sperm flagellar movement. | Plasma membrane calcium-transporting ATPase 1; Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-ind [...] | 0.513 |
CABCOCO1 | C4orf47 | ENSP00000328698 | ENSP00000368127 | Ciliary-associated calcium-binding coiled-coil protein 1; Calcium-binding protein. May be involved in the control of sperm flagellar movement. | UPF0602 protein C4orf47; Chromosome 4 open reading frame 47; Belongs to the UPF0602 family. | 0.502 |
CABCOCO1 | C5orf49 | ENSP00000328698 | ENSP00000382708 | Ciliary-associated calcium-binding coiled-coil protein 1; Calcium-binding protein. May be involved in the control of sperm flagellar movement. | Uncharacterized protein C5orf49; Chromosome 5 open reading frame 49. | 0.621 |
CABCOCO1 | CACNB2 | ENSP00000328698 | ENSP00000320025 | Ciliary-associated calcium-binding coiled-coil protein 1; Calcium-binding protein. May be involved in the control of sperm flagellar movement. | Voltage-dependent L-type calcium channel subunit beta-2; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. | 0.480 |
CABCOCO1 | CCDC96 | ENSP00000328698 | ENSP00000309285 | Ciliary-associated calcium-binding coiled-coil protein 1; Calcium-binding protein. May be involved in the control of sperm flagellar movement. | Coiled-coil domain containing 96. | 0.490 |
CABCOCO1 | FANCM | ENSP00000328698 | ENSP00000267430 | Ciliary-associated calcium-binding coiled-coil protein 1; Calcium-binding protein. May be involved in the control of sperm flagellar movement. | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross- linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork- structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This acti [...] | 0.532 |
CABCOCO1 | PLCD3 | ENSP00000328698 | ENSP00000479636 | Ciliary-associated calcium-binding coiled-coil protein 1; Calcium-binding protein. May be involved in the control of sperm flagellar movement. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow. | 0.673 |
CABCOCO1 | PLEKHA7 | ENSP00000328698 | ENSP00000435389 | Ciliary-associated calcium-binding coiled-coil protein 1; Calcium-binding protein. May be involved in the control of sperm flagellar movement. | Pleckstrin homology domain-containing family A member 7; Required for zonula adherens biogenesis and maintenance. Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site. Mediates docking of ADAM10 to zonula adherens through a PDZD11- dependent interaction with the ADAM10-binding protein TSPAN33. | 0.539 |
CABCOCO1 | TM9SF2 | ENSP00000328698 | ENSP00000493515 | Ciliary-associated calcium-binding coiled-coil protein 1; Calcium-binding protein. May be involved in the control of sperm flagellar movement. | Transmembrane 9 superfamily member 2; In the intracellular compartments, may function as a channel or small molecule transporter. | 0.594 |
CABCOCO1 | ZNF652 | ENSP00000328698 | ENSP00000354686 | Ciliary-associated calcium-binding coiled-coil protein 1; Calcium-binding protein. May be involved in the control of sperm flagellar movement. | Zinc finger protein 652; Functions as a transcriptional repressor. | 0.690 |