node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAPN15 | CAPNS1 | ENSP00000219611 | ENSP00000464849 | Calpain-15; Calpain 15; Belongs to the peptidase C2 family. | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | 0.775 |
CAPN15 | CAPNS2 | ENSP00000219611 | ENSP00000400882 | Calpain-15; Calpain 15; Belongs to the peptidase C2 family. | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity. | 0.675 |
CAPN15 | CAST | ENSP00000219611 | ENSP00000422176 | Calpain-15; Calpain 15; Belongs to the peptidase C2 family. | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family. | 0.662 |
CAPN15 | EFCAB7 | ENSP00000219611 | ENSP00000360129 | Calpain-15; Calpain 15; Belongs to the peptidase C2 family. | EF-hand calcium-binding domain-containing protein 7; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2:EVC subcomplex at the base of primary cilia. | 0.557 |
CAPN15 | HERPUD1 | ENSP00000219611 | ENSP00000409555 | Calpain-15; Calpain 15; Belongs to the peptidase C2 family. | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein; Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway. | 0.530 |
CAPN15 | IQCE | ENSP00000219611 | ENSP00000480715 | Calpain-15; Calpain 15; Belongs to the peptidase C2 family. | IQ domain-containing protein E; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (By similarity). Required for proper limb morphogenesis. | 0.488 |
CAPN15 | RNF126 | ENSP00000219611 | ENSP00000292363 | Calpain-15; Calpain 15; Belongs to the peptidase C2 family. | E3 ubiquitin-protein ligase RNF126; E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'- linked polyubiquitination of substrates (By similarity). Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targe [...] | 0.493 |
CAPN15 | ZNF236 | ENSP00000219611 | ENSP00000322361 | Calpain-15; Calpain 15; Belongs to the peptidase C2 family. | Zinc finger protein 236; May be involved in transcriptional regulation. | 0.522 |
CAPN15 | ZNF491 | ENSP00000219611 | ENSP00000313443 | Calpain-15; Calpain 15; Belongs to the peptidase C2 family. | Zinc finger protein 491; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.496 |
CAPN15 | ZNF594 | ENSP00000219611 | ENSP00000461032 | Calpain-15; Calpain 15; Belongs to the peptidase C2 family. | Zinc finger protein 594; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.573 |
CAPNS1 | CAPN15 | ENSP00000464849 | ENSP00000219611 | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | Calpain-15; Calpain 15; Belongs to the peptidase C2 family. | 0.775 |
CAPNS1 | CAPNS2 | ENSP00000464849 | ENSP00000400882 | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity. | 0.885 |
CAPNS1 | CAST | ENSP00000464849 | ENSP00000422176 | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family. | 0.995 |
CAPNS2 | CAPN15 | ENSP00000400882 | ENSP00000219611 | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity. | Calpain-15; Calpain 15; Belongs to the peptidase C2 family. | 0.675 |
CAPNS2 | CAPNS1 | ENSP00000400882 | ENSP00000464849 | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity. | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | 0.885 |
CAPNS2 | CAST | ENSP00000400882 | ENSP00000422176 | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity. | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family. | 0.929 |
CAST | CAPN15 | ENSP00000422176 | ENSP00000219611 | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family. | Calpain-15; Calpain 15; Belongs to the peptidase C2 family. | 0.662 |
CAST | CAPNS1 | ENSP00000422176 | ENSP00000464849 | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family. | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | 0.995 |
CAST | CAPNS2 | ENSP00000422176 | ENSP00000400882 | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family. | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity. | 0.929 |
EFCAB7 | CAPN15 | ENSP00000360129 | ENSP00000219611 | EF-hand calcium-binding domain-containing protein 7; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2:EVC subcomplex at the base of primary cilia. | Calpain-15; Calpain 15; Belongs to the peptidase C2 family. | 0.557 |