node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CARS1 | CARS2 | ENSP00000369897 | ENSP00000257347 | Cysteine--tRNA ligase, cytoplasmic; cysteinyl-tRNA synthetase 1. | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.913 |
CARS1 | EEF1G | ENSP00000369897 | ENSP00000331901 | Cysteine--tRNA ligase, cytoplasmic; cysteinyl-tRNA synthetase 1. | Elongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components. | 0.941 |
CARS1 | GARS1 | ENSP00000369897 | ENSP00000373918 | Cysteine--tRNA ligase, cytoplasmic; cysteinyl-tRNA synthetase 1. | Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.894 |
CARS1 | IARS1 | ENSP00000369897 | ENSP00000364794 | Cysteine--tRNA ligase, cytoplasmic; cysteinyl-tRNA synthetase 1. | Isoleucine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. | 0.905 |
CARS1 | IARS2 | ENSP00000369897 | ENSP00000355889 | Cysteine--tRNA ligase, cytoplasmic; cysteinyl-tRNA synthetase 1. | Isoleucine--tRNA ligase, mitochondrial; isoleucyl-tRNA synthetase 2, mitochondrial. | 0.901 |
CARS1 | LARS1 | ENSP00000369897 | ENSP00000377954 | Cysteine--tRNA ligase, cytoplasmic; cysteinyl-tRNA synthetase 1. | Leucine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs. | 0.950 |
CARS1 | LARS2 | ENSP00000369897 | ENSP00000498867 | Cysteine--tRNA ligase, cytoplasmic; cysteinyl-tRNA synthetase 1. | Probable leucine--tRNA ligase, mitochondrial; leucyl-tRNA synthetase 2, mitochondrial. | 0.923 |
CARS1 | PARS2 | ENSP00000369897 | ENSP00000360327 | Cysteine--tRNA ligase, cytoplasmic; cysteinyl-tRNA synthetase 1. | Probable proline--tRNA ligase, mitochondrial; prolyl-tRNA synthetase 2, mitochondrial. | 0.900 |
CARS1 | SARS1 | ENSP00000369897 | ENSP00000358939 | Cysteine--tRNA ligase, cytoplasmic; cysteinyl-tRNA synthetase 1. | Serine--tRNA ligase, cytoplasmic; Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). [...] | 0.913 |
CARS1 | YARS1 | ENSP00000369897 | ENSP00000362576 | Cysteine--tRNA ligase, cytoplasmic; cysteinyl-tRNA synthetase 1. | Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.898 |
CARS2 | CARS1 | ENSP00000257347 | ENSP00000369897 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | Cysteine--tRNA ligase, cytoplasmic; cysteinyl-tRNA synthetase 1. | 0.913 |
CARS2 | GARS1 | ENSP00000257347 | ENSP00000373918 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.807 |
CARS2 | IARS1 | ENSP00000257347 | ENSP00000364794 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | Isoleucine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. | 0.902 |
CARS2 | IARS2 | ENSP00000257347 | ENSP00000355889 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | Isoleucine--tRNA ligase, mitochondrial; isoleucyl-tRNA synthetase 2, mitochondrial. | 0.944 |
CARS2 | LARS1 | ENSP00000257347 | ENSP00000377954 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | Leucine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs. | 0.935 |
CARS2 | LARS2 | ENSP00000257347 | ENSP00000498867 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | Probable leucine--tRNA ligase, mitochondrial; leucyl-tRNA synthetase 2, mitochondrial. | 0.928 |
CARS2 | PARS2 | ENSP00000257347 | ENSP00000360327 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | Probable proline--tRNA ligase, mitochondrial; prolyl-tRNA synthetase 2, mitochondrial. | 0.909 |
CARS2 | SARS1 | ENSP00000257347 | ENSP00000358939 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | Serine--tRNA ligase, cytoplasmic; Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). [...] | 0.889 |
CARS2 | YARS1 | ENSP00000257347 | ENSP00000362576 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.882 |
EEF1G | CARS1 | ENSP00000331901 | ENSP00000369897 | Elongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components. | Cysteine--tRNA ligase, cytoplasmic; cysteinyl-tRNA synthetase 1. | 0.941 |