node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CBLL2 | OR1J4 | ENSP00000323348 | ENSP00000343521 | E3 ubiquitin-protein ligase CBLL2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates. | Olfactory receptor 1J4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.506 |
CBLL2 | OR5I1 | ENSP00000323348 | ENSP00000301532 | E3 ubiquitin-protein ligase CBLL2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates. | Olfactory receptor 5I1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.447 |
CBLL2 | PPP2R2D | ENSP00000323348 | ENSP00000399970 | E3 ubiquitin-protein ligase CBLL2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates. | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also ma [...] | 0.520 |
CBLL2 | SERTAD4 | ENSP00000323348 | ENSP00000355979 | E3 ubiquitin-protein ligase CBLL2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates. | SERTA domain containing 4. | 0.789 |
CBLL2 | SMCO3 | ENSP00000323348 | ENSP00000381895 | E3 ubiquitin-protein ligase CBLL2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates. | Single-pass membrane protein with coiled-coil domains 3. | 0.571 |
CBLL2 | TRIM63 | ENSP00000323348 | ENSP00000363390 | E3 ubiquitin-protein ligase CBLL2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates. | E3 ubiquitin-protein ligase TRIM63; E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-h [...] | 0.470 |
CBLL2 | UBE3D | ENSP00000323348 | ENSP00000358762 | E3 ubiquitin-protein ligase CBLL2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates. | E3 ubiquitin-protein ligase E3D; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. | 0.589 |
CBLL2 | VIRMA | ENSP00000323348 | ENSP00000297591 | E3 ubiquitin-protein ligase CBLL2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates. | Protein virilizer homolog; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites. Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon corr [...] | 0.738 |
CBLL2 | WTAP | ENSP00000323348 | ENSP00000351141 | E3 ubiquitin-protein ligase CBLL2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates. | Pre-mRNA-splicing regulator WTAP; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Required for accumulation of METTL3 and METTL14 to nuclear speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes. | 0.761 |
CBLL2 | ZC3H13 | ENSP00000323348 | ENSP00000242848 | E3 ubiquitin-protein ligase CBLL2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates. | Zinc finger CCCH domain-containing protein 13; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RN [...] | 0.645 |
OR1J4 | CBLL2 | ENSP00000343521 | ENSP00000323348 | Olfactory receptor 1J4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | E3 ubiquitin-protein ligase CBLL2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates. | 0.506 |
OR1J4 | SMCO3 | ENSP00000343521 | ENSP00000381895 | Olfactory receptor 1J4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Single-pass membrane protein with coiled-coil domains 3. | 0.658 |
OR5I1 | CBLL2 | ENSP00000301532 | ENSP00000323348 | Olfactory receptor 5I1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | E3 ubiquitin-protein ligase CBLL2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates. | 0.447 |
PPP2R2D | CBLL2 | ENSP00000399970 | ENSP00000323348 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also ma [...] | E3 ubiquitin-protein ligase CBLL2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates. | 0.520 |
PPP2R2D | SERTAD4 | ENSP00000399970 | ENSP00000355979 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also ma [...] | SERTA domain containing 4. | 0.795 |
SERTAD4 | CBLL2 | ENSP00000355979 | ENSP00000323348 | SERTA domain containing 4. | E3 ubiquitin-protein ligase CBLL2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates. | 0.789 |
SERTAD4 | PPP2R2D | ENSP00000355979 | ENSP00000399970 | SERTA domain containing 4. | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also ma [...] | 0.795 |
SMCO3 | CBLL2 | ENSP00000381895 | ENSP00000323348 | Single-pass membrane protein with coiled-coil domains 3. | E3 ubiquitin-protein ligase CBLL2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates. | 0.571 |
SMCO3 | OR1J4 | ENSP00000381895 | ENSP00000343521 | Single-pass membrane protein with coiled-coil domains 3. | Olfactory receptor 1J4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.658 |
TRIM63 | CBLL2 | ENSP00000363390 | ENSP00000323348 | E3 ubiquitin-protein ligase TRIM63; E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-h [...] | E3 ubiquitin-protein ligase CBLL2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates. | 0.470 |