node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRD20A3 | CBWD1 | ENSP00000482325 | ENSP00000366617 | Ankyrin repeat domain-containing protein 20A3. | COBW domain containing 1. | 0.512 |
ANKRD20A3 | CBWD6 | ENSP00000482325 | ENSP00000366608 | Ankyrin repeat domain-containing protein 20A3. | COBW domain containing 6; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | 0.550 |
CBWD1 | ANKRD20A3 | ENSP00000366617 | ENSP00000482325 | COBW domain containing 1. | Ankyrin repeat domain-containing protein 20A3. | 0.512 |
CBWD1 | CBWD2 | ENSP00000366617 | ENSP00000259199 | COBW domain containing 1. | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | 0.929 |
CBWD1 | CBWD6 | ENSP00000366617 | ENSP00000366608 | COBW domain containing 1. | COBW domain containing 6; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | 0.626 |
CBWD1 | DOCK8 | ENSP00000366617 | ENSP00000394888 | COBW domain containing 1. | Dedicator of cytokinesis protein 8; Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CC [...] | 0.482 |
CBWD1 | FOXD4 | ENSP00000366617 | ENSP00000371940 | COBW domain containing 1. | Forkhead box D4. | 0.600 |
CBWD1 | KIF22 | ENSP00000366617 | ENSP00000160827 | COBW domain containing 1. | Kinesin-like protein KIF22; Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells. | 0.586 |
CBWD1 | METAP1 | ENSP00000366617 | ENSP00000296411 | COBW domain containing 1. | Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle. | 0.738 |
CBWD1 | MRPL33 | ENSP00000366617 | ENSP00000296102 | COBW domain containing 1. | Mitochondrial ribosomal protein L33. | 0.489 |
CBWD1 | SETD2 | ENSP00000366617 | ENSP00000386759 | COBW domain containing 1. | Histone-lysine N-methyltransferase SETD2; Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate. It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair [...] | 0.501 |
CBWD1 | TCERG1 | ENSP00000366617 | ENSP00000296702 | COBW domain containing 1. | Transcription elongation regulator 1; Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter. | 0.662 |
CBWD2 | CBWD1 | ENSP00000259199 | ENSP00000366617 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | COBW domain containing 1. | 0.929 |
CBWD2 | CBWD6 | ENSP00000259199 | ENSP00000366608 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | COBW domain containing 6; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | 0.828 |
CBWD2 | METAP1 | ENSP00000259199 | ENSP00000296411 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle. | 0.843 |
CBWD2 | MRPL33 | ENSP00000259199 | ENSP00000296102 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | Mitochondrial ribosomal protein L33. | 0.518 |
CBWD2 | SETD2 | ENSP00000259199 | ENSP00000386759 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | Histone-lysine N-methyltransferase SETD2; Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate. It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair [...] | 0.497 |
CBWD2 | TCERG1 | ENSP00000259199 | ENSP00000296702 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | Transcription elongation regulator 1; Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter. | 0.748 |
CBWD6 | ANKRD20A3 | ENSP00000366608 | ENSP00000482325 | COBW domain containing 6; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | Ankyrin repeat domain-containing protein 20A3. | 0.550 |
CBWD6 | CBWD1 | ENSP00000366608 | ENSP00000366617 | COBW domain containing 6; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | COBW domain containing 1. | 0.626 |