node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGEF39 | CCDC107 | ENSP00000367638 | ENSP00000414964 | Rho guanine nucleotide exchange factor 39; Promotes cell proliferation. | Coiled-coil domain containing 107. | 0.402 |
CCDC107 | ARHGEF39 | ENSP00000414964 | ENSP00000367638 | Coiled-coil domain containing 107. | Rho guanine nucleotide exchange factor 39; Promotes cell proliferation. | 0.402 |
CCDC107 | CCDC84 | ENSP00000414964 | ENSP00000334767 | Coiled-coil domain containing 107. | Coiled-coil domain-containing protein 84. | 0.490 |
CCDC107 | DXO | ENSP00000414964 | ENSP00000364498 | Coiled-coil domain containing 107. | Decapping and exoribonuclease protein; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'- pyrophosphohydrolase activity by [...] | 0.477 |
CCDC107 | HBB | ENSP00000414964 | ENSP00000494175 | Coiled-coil domain containing 107. | Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. [Spinorphin]: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation; Belongs to the globin family. | 0.403 |
CCDC107 | LEPROTL1 | ENSP00000414964 | ENSP00000428281 | Coiled-coil domain containing 107. | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. Belongs to the OB-RGRP/VPS55 family. | 0.418 |
CCDC107 | TBC1D12 | ENSP00000414964 | ENSP00000225235 | Coiled-coil domain containing 107. | TBC1 domain family member 12; RAB11A-binding protein that plays a role in neurite outgrowth. | 0.513 |
CCDC107 | TEDC2 | ENSP00000414964 | ENSP00000355022 | Coiled-coil domain containing 107. | Tubulin epsilon and delta complex protein 2; Acts as a positive regulator of ciliary hedgehog signaling. Required for centriole stability. | 0.433 |
CCDC107 | WDR54 | ENSP00000414964 | ENSP00000006526 | Coiled-coil domain containing 107. | WD repeat-containing protein 54; When cross-linked to form dimers and trimers, it has a regulatory effect on ERK signaling pathway activity in response to EGF stimulation. Colocalizes with the EGF receptor in WDR54-specific vesicle where it sustains the internalization and controls the degradation of the EGF receptor after EGF stimulation. | 0.438 |
CCDC84 | CCDC107 | ENSP00000334767 | ENSP00000414964 | Coiled-coil domain-containing protein 84. | Coiled-coil domain containing 107. | 0.490 |
DXO | CCDC107 | ENSP00000364498 | ENSP00000414964 | Decapping and exoribonuclease protein; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'- pyrophosphohydrolase activity by [...] | Coiled-coil domain containing 107. | 0.477 |
HBB | CCDC107 | ENSP00000494175 | ENSP00000414964 | Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. [Spinorphin]: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation; Belongs to the globin family. | Coiled-coil domain containing 107. | 0.403 |
LEPROTL1 | CCDC107 | ENSP00000428281 | ENSP00000414964 | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. Belongs to the OB-RGRP/VPS55 family. | Coiled-coil domain containing 107. | 0.418 |
LEPROTL1 | TBC1D12 | ENSP00000428281 | ENSP00000225235 | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. Belongs to the OB-RGRP/VPS55 family. | TBC1 domain family member 12; RAB11A-binding protein that plays a role in neurite outgrowth. | 0.615 |
TBC1D12 | CCDC107 | ENSP00000225235 | ENSP00000414964 | TBC1 domain family member 12; RAB11A-binding protein that plays a role in neurite outgrowth. | Coiled-coil domain containing 107. | 0.513 |
TBC1D12 | LEPROTL1 | ENSP00000225235 | ENSP00000428281 | TBC1 domain family member 12; RAB11A-binding protein that plays a role in neurite outgrowth. | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. Belongs to the OB-RGRP/VPS55 family. | 0.615 |
TEDC2 | CCDC107 | ENSP00000355022 | ENSP00000414964 | Tubulin epsilon and delta complex protein 2; Acts as a positive regulator of ciliary hedgehog signaling. Required for centriole stability. | Coiled-coil domain containing 107. | 0.433 |
WDR54 | CCDC107 | ENSP00000006526 | ENSP00000414964 | WD repeat-containing protein 54; When cross-linked to form dimers and trimers, it has a regulatory effect on ERK signaling pathway activity in response to EGF stimulation. Colocalizes with the EGF receptor in WDR54-specific vesicle where it sustains the internalization and controls the degradation of the EGF receptor after EGF stimulation. | Coiled-coil domain containing 107. | 0.438 |