node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AP4E1 | CCDC117 | ENSP00000261842 | ENSP00000249064 | AP-4 complex subunit epsilon-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper [...] | Coiled-coil domain containing 117. | 0.448 |
CCDC117 | AP4E1 | ENSP00000249064 | ENSP00000261842 | Coiled-coil domain containing 117. | AP-4 complex subunit epsilon-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper [...] | 0.448 |
CCDC117 | HSP90AA1 | ENSP00000249064 | ENSP00000335153 | Coiled-coil domain containing 117. | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | 0.607 |
CCDC117 | HSPA4 | ENSP00000249064 | ENSP00000302961 | Coiled-coil domain containing 117. | Heat shock protein family A member 4; Belongs to the heat shock protein 70 family. | 0.488 |
CCDC117 | MEGF11 | ENSP00000249064 | ENSP00000386908 | Coiled-coil domain containing 117. | Multiple epidermal growth factor-like domains protein 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity); Belongs to the MEGF family. | 0.596 |
CCDC117 | MSANTD4 | ENSP00000249064 | ENSP00000304713 | Coiled-coil domain containing 117. | Myb/SANT-like DNA-binding domain-containing protein 4; Myb/SANT DNA binding domain containing 4 with coiled-coils. | 0.536 |
CCDC117 | PTAFR | ENSP00000249064 | ENSP00000442658 | Coiled-coil domain containing 117. | Platelet-activating factor receptor; Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. | 0.492 |
CCDC117 | SLC35B2 | ENSP00000249064 | ENSP00000377401 | Coiled-coil domain containing 117. | Adenosine 3'-phospho 5'-phosphosulfate transporter 1; Mediates the transport of adenosine 3'-phospho 5'- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in activation of the NF-kappa-B and MAPK pathways. | 0.481 |
CCDC117 | STIP1 | ENSP00000249064 | ENSP00000351646 | Coiled-coil domain containing 117. | Stress-induced-phosphoprotein 1; Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity). | 0.839 |
CCDC117 | TCEANC2 | ENSP00000249064 | ENSP00000234827 | Coiled-coil domain containing 117. | Transcription elongation factor A N-terminal and central domain containing 2. | 0.462 |
CCDC117 | VEPH1 | ENSP00000249064 | ENSP00000354919 | Coiled-coil domain containing 117. | Ventricular zone-expressed PH domain-containing protein homolog 1; Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling; Belongs to the MELT/VEPH family. | 0.606 |
HSP90AA1 | CCDC117 | ENSP00000335153 | ENSP00000249064 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | Coiled-coil domain containing 117. | 0.607 |
HSP90AA1 | HSPA4 | ENSP00000335153 | ENSP00000302961 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | Heat shock protein family A member 4; Belongs to the heat shock protein 70 family. | 0.999 |
HSP90AA1 | STIP1 | ENSP00000335153 | ENSP00000351646 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | Stress-induced-phosphoprotein 1; Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity). | 0.999 |
HSPA4 | CCDC117 | ENSP00000302961 | ENSP00000249064 | Heat shock protein family A member 4; Belongs to the heat shock protein 70 family. | Coiled-coil domain containing 117. | 0.488 |
HSPA4 | HSP90AA1 | ENSP00000302961 | ENSP00000335153 | Heat shock protein family A member 4; Belongs to the heat shock protein 70 family. | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | 0.999 |
HSPA4 | STIP1 | ENSP00000302961 | ENSP00000351646 | Heat shock protein family A member 4; Belongs to the heat shock protein 70 family. | Stress-induced-phosphoprotein 1; Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity). | 0.999 |
MEGF11 | CCDC117 | ENSP00000386908 | ENSP00000249064 | Multiple epidermal growth factor-like domains protein 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity); Belongs to the MEGF family. | Coiled-coil domain containing 117. | 0.596 |
MEGF11 | VEPH1 | ENSP00000386908 | ENSP00000354919 | Multiple epidermal growth factor-like domains protein 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity); Belongs to the MEGF family. | Ventricular zone-expressed PH domain-containing protein homolog 1; Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling; Belongs to the MELT/VEPH family. | 0.531 |
MSANTD4 | CCDC117 | ENSP00000304713 | ENSP00000249064 | Myb/SANT-like DNA-binding domain-containing protein 4; Myb/SANT DNA binding domain containing 4 with coiled-coils. | Coiled-coil domain containing 117. | 0.536 |