node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C2orf16 | CCDC121 | ENSP00000386190 | ENSP00000412150 | Uncharacterized protein C2orf16; Chromosome 2 open reading frame 16. | Coiled-coil domain containing 121. | 0.772 |
C2orf16 | FNDC4 | ENSP00000386190 | ENSP00000264703 | Uncharacterized protein C2orf16; Chromosome 2 open reading frame 16. | Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis. | 0.570 |
C2orf16 | GPN1 | ENSP00000386190 | ENSP00000264718 | Uncharacterized protein C2orf16; Chromosome 2 open reading frame 16. | GPN-loop GTPase 1; Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. May be involved in nuclear localization of XPA. | 0.610 |
C2orf16 | KRTCAP3 | ENSP00000386190 | ENSP00000442400 | Uncharacterized protein C2orf16; Chromosome 2 open reading frame 16. | Keratinocyte associated protein 3. | 0.447 |
C2orf16 | NRBP1 | ENSP00000386190 | ENSP00000369192 | Uncharacterized protein C2orf16; Chromosome 2 open reading frame 16. | Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. | 0.448 |
C2orf16 | SLC4A1AP | ENSP00000386190 | ENSP00000479964 | Uncharacterized protein C2orf16; Chromosome 2 open reading frame 16. | Kanadaptin; Solute carrier family 4 member 1 adaptor protein. | 0.543 |
C2orf16 | ZNF512 | ENSP00000386190 | ENSP00000347648 | Uncharacterized protein C2orf16; Chromosome 2 open reading frame 16. | Zinc finger protein 512; May be involved in transcriptional regulation. | 0.777 |
CCDC121 | C2orf16 | ENSP00000412150 | ENSP00000386190 | Coiled-coil domain containing 121. | Uncharacterized protein C2orf16; Chromosome 2 open reading frame 16. | 0.772 |
CCDC121 | FNDC4 | ENSP00000412150 | ENSP00000264703 | Coiled-coil domain containing 121. | Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis. | 0.541 |
CCDC121 | GPN1 | ENSP00000412150 | ENSP00000264718 | Coiled-coil domain containing 121. | GPN-loop GTPase 1; Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. May be involved in nuclear localization of XPA. | 0.582 |
CCDC121 | IFT172 | ENSP00000412150 | ENSP00000260570 | Coiled-coil domain containing 121. | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity); Belongs to the IFT172 family. | 0.502 |
CCDC121 | KRTCAP3 | ENSP00000412150 | ENSP00000442400 | Coiled-coil domain containing 121. | Keratinocyte associated protein 3. | 0.654 |
CCDC121 | NRBP1 | ENSP00000412150 | ENSP00000369192 | Coiled-coil domain containing 121. | Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. | 0.617 |
CCDC121 | SLC4A1AP | ENSP00000412150 | ENSP00000479964 | Coiled-coil domain containing 121. | Kanadaptin; Solute carrier family 4 member 1 adaptor protein. | 0.515 |
CCDC121 | TBC1D15 | ENSP00000412150 | ENSP00000448182 | Coiled-coil domain containing 121. | TBC1 domain family member 15; Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity). | 0.618 |
CCDC121 | TBC1D17 | ENSP00000412150 | ENSP00000221543 | Coiled-coil domain containing 121. | TBC1 domain family member 17; Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS- 50; the function requires its catalytic activity, however, the involved Rab is not known. | 0.817 |
CCDC121 | ZNF512 | ENSP00000412150 | ENSP00000347648 | Coiled-coil domain containing 121. | Zinc finger protein 512; May be involved in transcriptional regulation. | 0.729 |
FNDC4 | C2orf16 | ENSP00000264703 | ENSP00000386190 | Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis. | Uncharacterized protein C2orf16; Chromosome 2 open reading frame 16. | 0.570 |
FNDC4 | CCDC121 | ENSP00000264703 | ENSP00000412150 | Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis. | Coiled-coil domain containing 121. | 0.541 |
FNDC4 | GPN1 | ENSP00000264703 | ENSP00000264718 | Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis. | GPN-loop GTPase 1; Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. May be involved in nuclear localization of XPA. | 0.426 |