node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALMS1 | CCDC136 | ENSP00000482968 | ENSP00000297788 | Alstrom syndrome protein 1; Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells. | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization. | 0.545 |
ALMS1 | GCC2 | ENSP00000482968 | ENSP00000307939 | Alstrom syndrome protein 1; Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells. | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2. | 0.477 |
AP2M1 | CCDC136 | ENSP00000403362 | ENSP00000297788 | AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization. | 0.576 |
AP2M1 | MEGF10 | ENSP00000403362 | ENSP00000423354 | AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] | Multiple epidermal growth factor-like domains protein 10; Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. Necessary for astrocyte-dependent apoptotic neuron clearance in the developing cerebellum. Plays role in muscle cell proliferation, adhesion and motility. [...] | 0.810 |
CCDC136 | ALMS1 | ENSP00000297788 | ENSP00000482968 | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization. | Alstrom syndrome protein 1; Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells. | 0.545 |
CCDC136 | AP2M1 | ENSP00000297788 | ENSP00000403362 | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization. | AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] | 0.576 |
CCDC136 | CTTNBP2 | ENSP00000297788 | ENSP00000160373 | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization. | Cortactin-binding protein 2; Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance. | 0.572 |
CCDC136 | FAM90A7P | ENSP00000297788 | ENSP00000497076 | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization. | Putative protein FAM90A7P; Belongs to the FAM90 family. | 0.570 |
CCDC136 | GCC2 | ENSP00000297788 | ENSP00000307939 | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization. | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2. | 0.634 |
CCDC136 | MEGF10 | ENSP00000297788 | ENSP00000423354 | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization. | Multiple epidermal growth factor-like domains protein 10; Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. Necessary for astrocyte-dependent apoptotic neuron clearance in the developing cerebellum. Plays role in muscle cell proliferation, adhesion and motility. [...] | 0.832 |
CCDC136 | MEGF11 | ENSP00000297788 | ENSP00000386908 | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization. | Multiple epidermal growth factor-like domains protein 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity); Belongs to the MEGF family. | 0.619 |
CCDC136 | MEGF6 | ENSP00000297788 | ENSP00000348982 | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization. | Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6. | 0.624 |
CCDC136 | TMEM8B | ENSP00000297788 | ENSP00000367230 | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization. | Transmembrane protein 8B; May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion; Belongs to the TMEM8 family. | 0.679 |
CCDC136 | ZNF385D | ENSP00000297788 | ENSP00000281523 | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization. | Zinc finger protein 385D. | 0.606 |
CTTNBP2 | CCDC136 | ENSP00000160373 | ENSP00000297788 | Cortactin-binding protein 2; Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance. | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization. | 0.572 |
FAM90A7P | CCDC136 | ENSP00000497076 | ENSP00000297788 | Putative protein FAM90A7P; Belongs to the FAM90 family. | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization. | 0.570 |
GCC2 | ALMS1 | ENSP00000307939 | ENSP00000482968 | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2. | Alstrom syndrome protein 1; Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells. | 0.477 |
GCC2 | CCDC136 | ENSP00000307939 | ENSP00000297788 | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2. | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization. | 0.634 |
MEGF10 | AP2M1 | ENSP00000423354 | ENSP00000403362 | Multiple epidermal growth factor-like domains protein 10; Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. Necessary for astrocyte-dependent apoptotic neuron clearance in the developing cerebellum. Plays role in muscle cell proliferation, adhesion and motility. [...] | AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] | 0.810 |
MEGF10 | CCDC136 | ENSP00000423354 | ENSP00000297788 | Multiple epidermal growth factor-like domains protein 10; Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. Necessary for astrocyte-dependent apoptotic neuron clearance in the developing cerebellum. Plays role in muscle cell proliferation, adhesion and motility. [...] | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization. | 0.832 |