node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CBLN3 | CCDC137 | ENSP00000267406 | ENSP00000329360 | Cerebellin-3; May be involved in synaptic functions in the CNS. | Coiled-coil domain containing 137. | 0.573 |
CBLN3 | TMEM69 | ENSP00000267406 | ENSP00000361095 | Cerebellin-3; May be involved in synaptic functions in the CNS. | Transmembrane protein 69. | 0.581 |
CBLN3 | ZC3H10 | ENSP00000267406 | ENSP00000257940 | Cerebellin-3; May be involved in synaptic functions in the CNS. | Zinc finger CCCH domain-containing protein 10; Specific regulator of miRNA biogenesis. Binds, via the C3H1- type zinc finger domains, to the binding motif 5'-GCAGCGC-3' on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA. | 0.533 |
CCDC137 | CBLN3 | ENSP00000329360 | ENSP00000267406 | Coiled-coil domain containing 137. | Cerebellin-3; May be involved in synaptic functions in the CNS. | 0.573 |
CCDC137 | DDX27 | ENSP00000329360 | ENSP00000483495 | Coiled-coil domain containing 137. | Probable ATP-dependent RNA helicase DDX27; Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA. | 0.635 |
CCDC137 | GPATCH4 | ENSP00000329360 | ENSP00000396441 | Coiled-coil domain containing 137. | G-patch domain containing 4. | 0.558 |
CCDC137 | NIFK | ENSP00000329360 | ENSP00000285814 | Coiled-coil domain containing 137. | Nucleolar protein interacting with the FHA domain of MKI67. | 0.601 |
CCDC137 | NOL12 | ENSP00000329360 | ENSP00000352021 | Coiled-coil domain containing 137. | Nucleolar protein 12; May bind to 28S rRNA; Belongs to the RRP17 family. | 0.742 |
CCDC137 | NPM1 | ENSP00000329360 | ENSP00000296930 | Coiled-coil domain containing 137. | Nucleophosmin; Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. M [...] | 0.622 |
CCDC137 | RPL8 | ENSP00000329360 | ENSP00000262584 | Coiled-coil domain containing 137. | 60S ribosomal protein L8; Component of the large ribosomal subunit. | 0.615 |
CCDC137 | RRP8 | ENSP00000329360 | ENSP00000254605 | Coiled-coil domain containing 137. | Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] | 0.546 |
CCDC137 | TMEM69 | ENSP00000329360 | ENSP00000361095 | Coiled-coil domain containing 137. | Transmembrane protein 69. | 0.652 |
CCDC137 | ZC3H10 | ENSP00000329360 | ENSP00000257940 | Coiled-coil domain containing 137. | Zinc finger CCCH domain-containing protein 10; Specific regulator of miRNA biogenesis. Binds, via the C3H1- type zinc finger domains, to the binding motif 5'-GCAGCGC-3' on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA. | 0.630 |
DDX27 | CCDC137 | ENSP00000483495 | ENSP00000329360 | Probable ATP-dependent RNA helicase DDX27; Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA. | Coiled-coil domain containing 137. | 0.635 |
DDX27 | GPATCH4 | ENSP00000483495 | ENSP00000396441 | Probable ATP-dependent RNA helicase DDX27; Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA. | G-patch domain containing 4. | 0.678 |
DDX27 | NIFK | ENSP00000483495 | ENSP00000285814 | Probable ATP-dependent RNA helicase DDX27; Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA. | Nucleolar protein interacting with the FHA domain of MKI67. | 0.979 |
DDX27 | NOL12 | ENSP00000483495 | ENSP00000352021 | Probable ATP-dependent RNA helicase DDX27; Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA. | Nucleolar protein 12; May bind to 28S rRNA; Belongs to the RRP17 family. | 0.842 |
DDX27 | NPM1 | ENSP00000483495 | ENSP00000296930 | Probable ATP-dependent RNA helicase DDX27; Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA. | Nucleophosmin; Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. M [...] | 0.671 |
DDX27 | RRP8 | ENSP00000483495 | ENSP00000254605 | Probable ATP-dependent RNA helicase DDX27; Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA. | Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] | 0.915 |
GPATCH4 | CCDC137 | ENSP00000396441 | ENSP00000329360 | G-patch domain containing 4. | Coiled-coil domain containing 137. | 0.558 |