node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC113 | CCDC146 | ENSP00000219299 | ENSP00000285871 | Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation. | Coiled-coil domain containing 146. | 0.569 |
CCDC113 | CCDC96 | ENSP00000219299 | ENSP00000309285 | Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation. | Coiled-coil domain containing 96. | 0.602 |
CCDC113 | CFAP70 | ENSP00000219299 | ENSP00000310829 | Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation. | Cilia and flagella associated protein 70; Belongs to the CFAP70 family. | 0.567 |
CCDC146 | CCDC113 | ENSP00000285871 | ENSP00000219299 | Coiled-coil domain containing 146. | Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation. | 0.569 |
CCDC146 | CCDC65 | ENSP00000285871 | ENSP00000312706 | Coiled-coil domain containing 146. | Dynein regulatory complex subunit 2; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. Belongs to the DRC2 family. | 0.636 |
CCDC146 | CCDC96 | ENSP00000285871 | ENSP00000309285 | Coiled-coil domain containing 146. | Coiled-coil domain containing 96. | 0.658 |
CCDC146 | CFAP161 | ENSP00000285871 | ENSP00000286732 | Coiled-coil domain containing 146. | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly. | 0.558 |
CCDC146 | CFAP70 | ENSP00000285871 | ENSP00000310829 | Coiled-coil domain containing 146. | Cilia and flagella associated protein 70; Belongs to the CFAP70 family. | 0.567 |
CCDC146 | GMNN | ENSP00000285871 | ENSP00000230056 | Coiled-coil domain containing 146. | Geminin; Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle; Belongs to the geminin family. | 0.739 |
CCDC146 | KRT38 | ENSP00000285871 | ENSP00000246646 | Coiled-coil domain containing 146. | Keratin, type I cuticular Ha8; Keratin 38; Belongs to the intermediate filament family. | 0.561 |
CCDC146 | LRRC34 | ENSP00000285871 | ENSP00000414635 | Coiled-coil domain containing 146. | Leucine-rich repeat-containing protein 34; Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro. | 0.577 |
CCDC146 | RAB3IP | ENSP00000285871 | ENSP00000447300 | Coiled-coil domain containing 146. | Rab-3A-interacting protein; Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface forma [...] | 0.620 |
CCDC146 | TSNAXIP1 | ENSP00000285871 | ENSP00000457241 | Coiled-coil domain containing 146. | Translin-associated factor X-interacting protein 1; Possible role in spermatogenesis. | 0.592 |
CCDC65 | CCDC146 | ENSP00000312706 | ENSP00000285871 | Dynein regulatory complex subunit 2; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. Belongs to the DRC2 family. | Coiled-coil domain containing 146. | 0.636 |
CCDC65 | CCDC96 | ENSP00000312706 | ENSP00000309285 | Dynein regulatory complex subunit 2; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. Belongs to the DRC2 family. | Coiled-coil domain containing 96. | 0.488 |
CCDC65 | CFAP161 | ENSP00000312706 | ENSP00000286732 | Dynein regulatory complex subunit 2; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. Belongs to the DRC2 family. | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly. | 0.549 |
CCDC65 | CFAP70 | ENSP00000312706 | ENSP00000310829 | Dynein regulatory complex subunit 2; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. Belongs to the DRC2 family. | Cilia and flagella associated protein 70; Belongs to the CFAP70 family. | 0.529 |
CCDC65 | LRRC34 | ENSP00000312706 | ENSP00000414635 | Dynein regulatory complex subunit 2; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. Belongs to the DRC2 family. | Leucine-rich repeat-containing protein 34; Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro. | 0.511 |
CCDC65 | TSNAXIP1 | ENSP00000312706 | ENSP00000457241 | Dynein regulatory complex subunit 2; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. Belongs to the DRC2 family. | Translin-associated factor X-interacting protein 1; Possible role in spermatogenesis. | 0.443 |
CCDC96 | CCDC113 | ENSP00000309285 | ENSP00000219299 | Coiled-coil domain containing 96. | Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation. | 0.602 |