node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC146 | CCDC159 | ENSP00000285871 | ENSP00000468232 | Coiled-coil domain containing 146. | Coiled-coil domain containing 159. | 0.517 |
CCDC159 | CCDC146 | ENSP00000468232 | ENSP00000285871 | Coiled-coil domain containing 159. | Coiled-coil domain containing 146. | 0.517 |
CCDC159 | CIAO3 | ENSP00000468232 | ENSP00000251588 | Coiled-coil domain containing 159. | Cytosolic iron-sulfur assembly component 3; Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect; Belongs to the NARF family. | 0.469 |
CCDC159 | PLPPR2 | ENSP00000468232 | ENSP00000466898 | Coiled-coil domain containing 159. | Phospholipid phosphatase-related protein type 2; Phospholipid phosphatase related 2. | 0.634 |
CCDC159 | RELT | ENSP00000468232 | ENSP00000064780 | Coiled-coil domain containing 159. | Tumor necrosis factor receptor superfamily member 19L; May play a role in apoptosis. Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed. Involved in dental enamel formation. Belongs to the RELT family. | 0.428 |
CCDC159 | SINHCAF | ENSP00000468232 | ENSP00000337477 | Coiled-coil domain containing 159. | SIN3-HDAC complex-associated factor; Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway. Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells. Promotes the stability of SIN3A and its presence on chromatin and is essential for maintaining the potential of ES cells to proliferate rapidly, while ensuring a short G1-phase of the cell cycle, thereby preventing premature lineage priming (By sim [...] | 0.473 |
CCDC159 | SWSAP1 | ENSP00000468232 | ENSP00000310008 | Coiled-coil domain containing 159. | ATPase SWSAP1; ATPase which is preferentially stimulated by single-stranded DNA and is involved in homologous recombination repair (HRR). Has a DNA-binding activity which is independent of its ATPase activity. | 0.483 |
CCDC159 | TMEM205 | ENSP00000468232 | ENSP00000346954 | Coiled-coil domain containing 159. | Transmembrane protein 205; In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin. | 0.455 |
CCDC159 | UROS | ENSP00000468232 | ENSP00000357787 | Coiled-coil domain containing 159. | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme). | 0.468 |
CIAO3 | CCDC159 | ENSP00000251588 | ENSP00000468232 | Cytosolic iron-sulfur assembly component 3; Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect; Belongs to the NARF family. | Coiled-coil domain containing 159. | 0.469 |
PLPPR2 | CCDC159 | ENSP00000466898 | ENSP00000468232 | Phospholipid phosphatase-related protein type 2; Phospholipid phosphatase related 2. | Coiled-coil domain containing 159. | 0.634 |
PLPPR2 | SWSAP1 | ENSP00000466898 | ENSP00000310008 | Phospholipid phosphatase-related protein type 2; Phospholipid phosphatase related 2. | ATPase SWSAP1; ATPase which is preferentially stimulated by single-stranded DNA and is involved in homologous recombination repair (HRR). Has a DNA-binding activity which is independent of its ATPase activity. | 0.454 |
RELT | CCDC159 | ENSP00000064780 | ENSP00000468232 | Tumor necrosis factor receptor superfamily member 19L; May play a role in apoptosis. Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed. Involved in dental enamel formation. Belongs to the RELT family. | Coiled-coil domain containing 159. | 0.428 |
SINHCAF | CCDC159 | ENSP00000337477 | ENSP00000468232 | SIN3-HDAC complex-associated factor; Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway. Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells. Promotes the stability of SIN3A and its presence on chromatin and is essential for maintaining the potential of ES cells to proliferate rapidly, while ensuring a short G1-phase of the cell cycle, thereby preventing premature lineage priming (By sim [...] | Coiled-coil domain containing 159. | 0.473 |
SWSAP1 | CCDC159 | ENSP00000310008 | ENSP00000468232 | ATPase SWSAP1; ATPase which is preferentially stimulated by single-stranded DNA and is involved in homologous recombination repair (HRR). Has a DNA-binding activity which is independent of its ATPase activity. | Coiled-coil domain containing 159. | 0.483 |
SWSAP1 | PLPPR2 | ENSP00000310008 | ENSP00000466898 | ATPase SWSAP1; ATPase which is preferentially stimulated by single-stranded DNA and is involved in homologous recombination repair (HRR). Has a DNA-binding activity which is independent of its ATPase activity. | Phospholipid phosphatase-related protein type 2; Phospholipid phosphatase related 2. | 0.454 |
TMEM205 | CCDC159 | ENSP00000346954 | ENSP00000468232 | Transmembrane protein 205; In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin. | Coiled-coil domain containing 159. | 0.455 |
UROS | CCDC159 | ENSP00000357787 | ENSP00000468232 | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme). | Coiled-coil domain containing 159. | 0.468 |