node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCHCR1 | CDSN | ENSP00000379566 | ENSP00000365465 | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation. | Corneodesmosin; Important for the epidermal barrier integrity. | 0.921 |
CCHCR1 | HLA-C | ENSP00000379566 | ENSP00000365402 | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation. | HLA class I histocompatibility antigen, C alpha chain; Antigen-presenting major histocompatibility complex class I (MHCI) molecule with an important role in reproduction and antiviral immunity. In complex with B2M/beta 2 microglobulin displays a restricted repertoire of self and viral peptides and acts as a dominant ligand for inhibitory and activating killer immunoglobulin receptors (KIRs) expressed on NK cells. In an allogeneic setting, such as during pregnancy, mediates interaction of extravillous trophoblasts with KIR on uterine NK cells and regulate trophoblast invasion necessary [...] | 0.852 |
CCHCR1 | IQCC | ENSP00000379566 | ENSP00000442291 | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation. | IQ motif containing C. | 0.777 |
CCHCR1 | KRT16 | ENSP00000379566 | ENSP00000301653 | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation. | Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance; Belongs to the intermediate filament family. | 0.700 |
CCHCR1 | KRT17 | ENSP00000379566 | ENSP00000308452 | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation. | Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a mark [...] | 0.679 |
CCHCR1 | KRT6A | ENSP00000379566 | ENSP00000369317 | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation. | Keratin, type II cytoskeletal 6A; Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. Belongs to the intermediate filament family. | 0.648 |
CCHCR1 | PSORS1C1 | ENSP00000379566 | ENSP00000259881 | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation. | Psoriasis susceptibility 1 candidate 1. | 0.645 |
CCHCR1 | PSORS1C2 | ENSP00000379566 | ENSP00000259845 | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation. | Psoriasis susceptibility 1 candidate 2. | 0.778 |
CCHCR1 | STAR | ENSP00000379566 | ENSP00000276449 | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation. | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. | 0.778 |
CCHCR1 | TCF19 | ENSP00000379566 | ENSP00000365433 | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation. | Transcription factor 19; Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression. | 0.799 |
CDSN | CCHCR1 | ENSP00000365465 | ENSP00000379566 | Corneodesmosin; Important for the epidermal barrier integrity. | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation. | 0.921 |
CDSN | HLA-C | ENSP00000365465 | ENSP00000365402 | Corneodesmosin; Important for the epidermal barrier integrity. | HLA class I histocompatibility antigen, C alpha chain; Antigen-presenting major histocompatibility complex class I (MHCI) molecule with an important role in reproduction and antiviral immunity. In complex with B2M/beta 2 microglobulin displays a restricted repertoire of self and viral peptides and acts as a dominant ligand for inhibitory and activating killer immunoglobulin receptors (KIRs) expressed on NK cells. In an allogeneic setting, such as during pregnancy, mediates interaction of extravillous trophoblasts with KIR on uterine NK cells and regulate trophoblast invasion necessary [...] | 0.845 |
CDSN | KRT16 | ENSP00000365465 | ENSP00000301653 | Corneodesmosin; Important for the epidermal barrier integrity. | Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance; Belongs to the intermediate filament family. | 0.593 |
CDSN | KRT17 | ENSP00000365465 | ENSP00000308452 | Corneodesmosin; Important for the epidermal barrier integrity. | Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a mark [...] | 0.504 |
CDSN | KRT6A | ENSP00000365465 | ENSP00000369317 | Corneodesmosin; Important for the epidermal barrier integrity. | Keratin, type II cytoskeletal 6A; Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. Belongs to the intermediate filament family. | 0.508 |
CDSN | PSORS1C1 | ENSP00000365465 | ENSP00000259881 | Corneodesmosin; Important for the epidermal barrier integrity. | Psoriasis susceptibility 1 candidate 1. | 0.946 |
CDSN | PSORS1C2 | ENSP00000365465 | ENSP00000259845 | Corneodesmosin; Important for the epidermal barrier integrity. | Psoriasis susceptibility 1 candidate 2. | 0.739 |
CDSN | TCF19 | ENSP00000365465 | ENSP00000365433 | Corneodesmosin; Important for the epidermal barrier integrity. | Transcription factor 19; Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression. | 0.646 |
HLA-C | CCHCR1 | ENSP00000365402 | ENSP00000379566 | HLA class I histocompatibility antigen, C alpha chain; Antigen-presenting major histocompatibility complex class I (MHCI) molecule with an important role in reproduction and antiviral immunity. In complex with B2M/beta 2 microglobulin displays a restricted repertoire of self and viral peptides and acts as a dominant ligand for inhibitory and activating killer immunoglobulin receptors (KIRs) expressed on NK cells. In an allogeneic setting, such as during pregnancy, mediates interaction of extravillous trophoblasts with KIR on uterine NK cells and regulate trophoblast invasion necessary [...] | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation. | 0.852 |
HLA-C | CDSN | ENSP00000365402 | ENSP00000365465 | HLA class I histocompatibility antigen, C alpha chain; Antigen-presenting major histocompatibility complex class I (MHCI) molecule with an important role in reproduction and antiviral immunity. In complex with B2M/beta 2 microglobulin displays a restricted repertoire of self and viral peptides and acts as a dominant ligand for inhibitory and activating killer immunoglobulin receptors (KIRs) expressed on NK cells. In an allogeneic setting, such as during pregnancy, mediates interaction of extravillous trophoblasts with KIR on uterine NK cells and regulate trophoblast invasion necessary [...] | Corneodesmosin; Important for the epidermal barrier integrity. | 0.845 |