node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C15orf61 | C16orf91 | ENSP00000342254 | ENSP00000413100 | Uncharacterized protein C15orf61; Chromosome 15 open reading frame 61. | Protein CCSMST1; Chromosome 16 open reading frame 91. | 0.522 |
C15orf61 | DMAC1 | ENSP00000342254 | ENSP00000350961 | Uncharacterized protein C15orf61; Chromosome 15 open reading frame 61. | Distal membrane-arm assembly complex protein 1; Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I. | 0.431 |
C15orf61 | NDUFAF8 | ENSP00000342254 | ENSP00000400184 | Uncharacterized protein C15orf61; Chromosome 15 open reading frame 61. | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8; Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1). Required to stabilize NDUFAF5. | 0.430 |
C16orf91 | C15orf61 | ENSP00000413100 | ENSP00000342254 | Protein CCSMST1; Chromosome 16 open reading frame 91. | Uncharacterized protein C15orf61; Chromosome 15 open reading frame 61. | 0.522 |
C16orf91 | COX20 | ENSP00000413100 | ENSP00000355486 | Protein CCSMST1; Chromosome 16 open reading frame 91. | Cytochrome c oxidase assembly protein COX20, mitochondrial; Essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Acts as a chaperone in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation, stabilizing the newly synthesized protein and presenting it to metallochaperones SCO1/2 which in turn facilitates the incorporation of the mature MT-CO2/COX2 into the assembling CIV holoenzyme. | 0.682 |
C16orf91 | DMAC1 | ENSP00000413100 | ENSP00000350961 | Protein CCSMST1; Chromosome 16 open reading frame 91. | Distal membrane-arm assembly complex protein 1; Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I. | 0.417 |
C16orf91 | GKN1 | ENSP00000413100 | ENSP00000501093 | Protein CCSMST1; Chromosome 16 open reading frame 91. | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. | 0.484 |
C16orf91 | GKN2 | ENSP00000413100 | ENSP00000329292 | Protein CCSMST1; Chromosome 16 open reading frame 91. | Gastrokine-2; Gastrokine 2. | 0.508 |
C16orf91 | MAGEF1 | ENSP00000413100 | ENSP00000315064 | Protein CCSMST1; Chromosome 16 open reading frame 91. | Melanoma-associated antigen F1; Enhances ubiquitin ligase activity of RING-type zinc finger- containing E3 ubiquitin ligases. Proposed to act through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. MAGEF1-NSMCE1 ubiquitin ligase complex promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors. [...] | 0.405 |
C16orf91 | NDUFAF8 | ENSP00000413100 | ENSP00000400184 | Protein CCSMST1; Chromosome 16 open reading frame 91. | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8; Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1). Required to stabilize NDUFAF5. | 0.421 |
C16orf91 | NTMT1 | ENSP00000413100 | ENSP00000483489 | Protein CCSMST1; Chromosome 16 open reading frame 91. | N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed; Distributive alpha-N-methyltransferase that methylates the N- terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]- Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly [...] | 0.407 |
C16orf91 | UQCC2 | ENSP00000413100 | ENSP00000476140 | Protein CCSMST1; Chromosome 16 open reading frame 91. | Ubiquinol-cytochrome-c reductase complex assembly factor 2; Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Plays a role in the modulation of respiratory chain activities such as oxygen consumption and ATP production and via its modulation of the respiratory chain activity can regulate skeletal muscle differentiation and insulin secretion by pancreatic beta-cells. Involved in cytochrome b translation and/or stability. | 0.616 |
COX20 | C16orf91 | ENSP00000355486 | ENSP00000413100 | Cytochrome c oxidase assembly protein COX20, mitochondrial; Essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Acts as a chaperone in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation, stabilizing the newly synthesized protein and presenting it to metallochaperones SCO1/2 which in turn facilitates the incorporation of the mature MT-CO2/COX2 into the assembling CIV holoenzyme. | Protein CCSMST1; Chromosome 16 open reading frame 91. | 0.682 |
COX20 | UQCC2 | ENSP00000355486 | ENSP00000476140 | Cytochrome c oxidase assembly protein COX20, mitochondrial; Essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Acts as a chaperone in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation, stabilizing the newly synthesized protein and presenting it to metallochaperones SCO1/2 which in turn facilitates the incorporation of the mature MT-CO2/COX2 into the assembling CIV holoenzyme. | Ubiquinol-cytochrome-c reductase complex assembly factor 2; Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Plays a role in the modulation of respiratory chain activities such as oxygen consumption and ATP production and via its modulation of the respiratory chain activity can regulate skeletal muscle differentiation and insulin secretion by pancreatic beta-cells. Involved in cytochrome b translation and/or stability. | 0.887 |
DMAC1 | C15orf61 | ENSP00000350961 | ENSP00000342254 | Distal membrane-arm assembly complex protein 1; Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I. | Uncharacterized protein C15orf61; Chromosome 15 open reading frame 61. | 0.431 |
DMAC1 | C16orf91 | ENSP00000350961 | ENSP00000413100 | Distal membrane-arm assembly complex protein 1; Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I. | Protein CCSMST1; Chromosome 16 open reading frame 91. | 0.417 |
GKN1 | C16orf91 | ENSP00000501093 | ENSP00000413100 | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. | Protein CCSMST1; Chromosome 16 open reading frame 91. | 0.484 |
GKN1 | GKN2 | ENSP00000501093 | ENSP00000329292 | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. | Gastrokine-2; Gastrokine 2. | 0.731 |
GKN2 | C16orf91 | ENSP00000329292 | ENSP00000413100 | Gastrokine-2; Gastrokine 2. | Protein CCSMST1; Chromosome 16 open reading frame 91. | 0.508 |
GKN2 | GKN1 | ENSP00000329292 | ENSP00000501093 | Gastrokine-2; Gastrokine 2. | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. | 0.731 |