node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARL2 | ARL3 | ENSP00000246747 | ENSP00000260746 | ADP-ribosylation factor-like protein 2; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the ef [...] | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliar [...] | 0.458 |
ARL2 | CFAP36 | ENSP00000246747 | ENSP00000342699 | ADP-ribosylation factor-like protein 2; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the ef [...] | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | 0.504 |
ARL3 | ARL2 | ENSP00000260746 | ENSP00000246747 | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliar [...] | ADP-ribosylation factor-like protein 2; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the ef [...] | 0.458 |
ARL3 | C20orf194 | ENSP00000260746 | ENSP00000252032 | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliar [...] | Uncharacterized protein C20orf194; May act as an effector for ARL3. | 0.706 |
ARL3 | CFAP36 | ENSP00000260746 | ENSP00000342699 | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliar [...] | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | 0.974 |
C20orf194 | ARL3 | ENSP00000252032 | ENSP00000260746 | Uncharacterized protein C20orf194; May act as an effector for ARL3. | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliar [...] | 0.706 |
C20orf194 | CFAP36 | ENSP00000252032 | ENSP00000342699 | Uncharacterized protein C20orf194; May act as an effector for ARL3. | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | 0.484 |
CCDC63 | CFAP36 | ENSP00000312399 | ENSP00000342699 | Coiled-coil domain-containing protein 63; Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads. | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | 0.510 |
CCDC63 | RIBC2 | ENSP00000312399 | ENSP00000483356 | Coiled-coil domain-containing protein 63; Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads. | RIB43A domain with coiled-coils 2. | 0.535 |
CCDC63 | TTC29 | ENSP00000312399 | ENSP00000423505 | Coiled-coil domain-containing protein 63; Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads. | Tetratricopeptide repeat domain 29. | 0.502 |
CCDC96 | CFAP36 | ENSP00000309285 | ENSP00000342699 | Coiled-coil domain containing 96. | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | 0.453 |
CFAP36 | ARL2 | ENSP00000342699 | ENSP00000246747 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | ADP-ribosylation factor-like protein 2; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the ef [...] | 0.504 |
CFAP36 | ARL3 | ENSP00000342699 | ENSP00000260746 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliar [...] | 0.974 |
CFAP36 | C20orf194 | ENSP00000342699 | ENSP00000252032 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | Uncharacterized protein C20orf194; May act as an effector for ARL3. | 0.484 |
CFAP36 | CCDC63 | ENSP00000342699 | ENSP00000312399 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | Coiled-coil domain-containing protein 63; Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads. | 0.510 |
CFAP36 | CCDC96 | ENSP00000342699 | ENSP00000309285 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | Coiled-coil domain containing 96. | 0.453 |
CFAP36 | FAM161B | ENSP00000342699 | ENSP00000499021 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | FAM161 centrosomal protein B; Belongs to the FAM161 family. | 0.621 |
CFAP36 | FAM81B | ENSP00000342699 | ENSP00000283357 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | Protein FAM81B; Family with sequence similarity 81 member B. | 0.542 |
CFAP36 | RIBC2 | ENSP00000342699 | ENSP00000483356 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | RIB43A domain with coiled-coils 2. | 0.460 |
CFAP36 | SPICE1 | ENSP00000342699 | ENSP00000295872 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | Spindle and centriole-associated protein 1; Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. | 0.455 |