node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALS2 | CFAP410 | ENSP00000264276 | ENSP00000381047 | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). | Cilia and flagella associated protein 410. | 0.875 |
ALS2 | CHCHD10 | ENSP00000264276 | ENSP00000384973 | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). | Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial; May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure. | 0.724 |
ALS2 | MATR3 | ENSP00000264276 | ENSP00000378284 | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). | Matrin 3. | 0.614 |
ALS2 | MATR3-2 | ENSP00000264276 | ENSP00000354346 | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). | Matrin-3; May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. May bind to specific miRNA hairpins. | 0.614 |
ALS2 | NEK1 | ENSP00000264276 | ENSP00000424757 | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). | Serine/threonine-protein kinase Nek1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis (By similarity). Involved in cilium assembly. | 0.942 |
CFAP410 | ALS2 | ENSP00000381047 | ENSP00000264276 | Cilia and flagella associated protein 410. | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). | 0.875 |
CFAP410 | CHCHD10 | ENSP00000381047 | ENSP00000384973 | Cilia and flagella associated protein 410. | Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial; May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure. | 0.631 |
CFAP410 | FXN | ENSP00000381047 | ENSP00000419243 | Cilia and flagella associated protein 410. | Frataxin intermediate form; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has on [...] | 0.597 |
CFAP410 | MATR3 | ENSP00000381047 | ENSP00000378284 | Cilia and flagella associated protein 410. | Matrin 3. | 0.570 |
CFAP410 | MATR3-2 | ENSP00000381047 | ENSP00000354346 | Cilia and flagella associated protein 410. | Matrin-3; May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. May bind to specific miRNA hairpins. | 0.570 |
CFAP410 | MX1 | ENSP00000381047 | ENSP00000381601 | Cilia and flagella associated protein 410. | Interferon-induced GTP-binding protein Mx1, N-terminally processed; Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing g [...] | 0.773 |
CFAP410 | NEK1 | ENSP00000381047 | ENSP00000424757 | Cilia and flagella associated protein 410. | Serine/threonine-protein kinase Nek1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis (By similarity). Involved in cilium assembly. | 0.982 |
CFAP410 | PFKL | ENSP00000381047 | ENSP00000269848 | Cilia and flagella associated protein 410. | ATP-dependent 6-phosphofructokinase, liver type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity). Belongs to the phosphofructokinase type A (PFKA) famil [...] | 0.784 |
CFAP410 | SPATA7 | ENSP00000381047 | ENSP00000377176 | Cilia and flagella associated protein 410. | Spermatogenesis-associated protein 7; Involved in the maintenance of both rod and cone photoreceptor cells (By similarity). It is required for recruitment and proper localization of RPGRIP1 to the photoreceptor connecting cilium (CC), as well as photoreceptor-specific localization of proximal CC proteins at the distal CC (By similarity). Maintenance of protein localization at the photoreceptor-specific distal CC is essential for normal microtubule stability and to prevent photoreceptor degeneration (By similarity). | 0.660 |
CFAP410 | VTN | ENSP00000381047 | ENSP00000226218 | Cilia and flagella associated protein 410. | Vitronectin V10 subunit; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. | 0.606 |
CHCHD10 | ALS2 | ENSP00000384973 | ENSP00000264276 | Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial; May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure. | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). | 0.724 |
CHCHD10 | CFAP410 | ENSP00000384973 | ENSP00000381047 | Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial; May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure. | Cilia and flagella associated protein 410. | 0.631 |
CHCHD10 | MATR3 | ENSP00000384973 | ENSP00000378284 | Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial; May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure. | Matrin 3. | 0.736 |
CHCHD10 | MATR3-2 | ENSP00000384973 | ENSP00000354346 | Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial; May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure. | Matrin-3; May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. May bind to specific miRNA hairpins. | 0.736 |
CHCHD10 | NEK1 | ENSP00000384973 | ENSP00000424757 | Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial; May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure. | Serine/threonine-protein kinase Nek1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis (By similarity). Involved in cilium assembly. | 0.733 |