node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CGREF1 | CGRRF1 | ENSP00000385452 | ENSP00000216420 | Cell growth regulator with EF hand domain protein 1; Mediates cell-cell adhesion in a calcium-dependent manner (By similarity). Able to inhibit growth in several cell lines. | Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines. | 0.960 |
CGRRF1 | CGREF1 | ENSP00000216420 | ENSP00000385452 | Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines. | Cell growth regulator with EF hand domain protein 1; Mediates cell-cell adhesion in a calcium-dependent manner (By similarity). Able to inhibit growth in several cell lines. | 0.960 |
CGRRF1 | CNIH1 | ENSP00000216420 | ENSP00000216416 | Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines. | Protein cornichon homolog 1; Involved in the selective transport and maturation of TGF- alpha family proteins; Belongs to the cornichon family. | 0.544 |
CGRRF1 | FAM8A1 | ENSP00000216420 | ENSP00000259963 | Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines. | Protein FAM8A1; Family with sequence similarity 8 member A1. | 0.501 |
CGRRF1 | GMFB | ENSP00000216420 | ENSP00000350757 | Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines. | Glia maturation factor beta; This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells; Belongs to the actin-binding proteins ADF family. GMF subfamily. | 0.511 |
CGRRF1 | RNF170 | ENSP00000216420 | ENSP00000445725 | Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines. | E3 ubiquitin-protein ligase RNF170; E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. | 0.516 |
CGRRF1 | RNF26 | ENSP00000216420 | ENSP00000312439 | Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines. | E3 ubiquitin-protein ligase RNF26; E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud. Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1. Ubiquitinated SQSTM1 attracts specific vesicle- associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Also acts as a regulator of type I interferon production in response to viral infection by mediating th [...] | 0.447 |
CGRRF1 | RNFT1 | ENSP00000216420 | ENSP00000304670 | Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines. | E3 ubiquitin-protein ligase RNFT1; E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. | 0.592 |
CGRRF1 | SEL1L | ENSP00000216420 | ENSP00000337053 | Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines. | Protein sel-1 homolog 1; Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling. | 0.483 |
CGRRF1 | UBE2J1 | ENSP00000216420 | ENSP00000451261 | Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines. | Ubiquitin-conjugating enzyme E2 J1; Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). Belongs to the ubiquitin-conjugating enzyme family. | 0.464 |
CGRRF1 | UBE2J2 | ENSP00000216420 | ENSP00000383719 | Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines. | Ubiquitin-conjugating enzyme E2 J2; Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). Belongs to the ubiquitin-conjugating enzyme family. | 0.602 |
CNIH1 | CGRRF1 | ENSP00000216416 | ENSP00000216420 | Protein cornichon homolog 1; Involved in the selective transport and maturation of TGF- alpha family proteins; Belongs to the cornichon family. | Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines. | 0.544 |
CNIH1 | GMFB | ENSP00000216416 | ENSP00000350757 | Protein cornichon homolog 1; Involved in the selective transport and maturation of TGF- alpha family proteins; Belongs to the cornichon family. | Glia maturation factor beta; This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells; Belongs to the actin-binding proteins ADF family. GMF subfamily. | 0.483 |
FAM8A1 | CGRRF1 | ENSP00000259963 | ENSP00000216420 | Protein FAM8A1; Family with sequence similarity 8 member A1. | Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines. | 0.501 |
FAM8A1 | RNF170 | ENSP00000259963 | ENSP00000445725 | Protein FAM8A1; Family with sequence similarity 8 member A1. | E3 ubiquitin-protein ligase RNF170; E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. | 0.509 |
FAM8A1 | SEL1L | ENSP00000259963 | ENSP00000337053 | Protein FAM8A1; Family with sequence similarity 8 member A1. | Protein sel-1 homolog 1; Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling. | 0.978 |
FAM8A1 | UBE2J1 | ENSP00000259963 | ENSP00000451261 | Protein FAM8A1; Family with sequence similarity 8 member A1. | Ubiquitin-conjugating enzyme E2 J1; Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). Belongs to the ubiquitin-conjugating enzyme family. | 0.634 |
GMFB | CGRRF1 | ENSP00000350757 | ENSP00000216420 | Glia maturation factor beta; This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells; Belongs to the actin-binding proteins ADF family. GMF subfamily. | Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines. | 0.511 |
GMFB | CNIH1 | ENSP00000350757 | ENSP00000216416 | Glia maturation factor beta; This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells; Belongs to the actin-binding proteins ADF family. GMF subfamily. | Protein cornichon homolog 1; Involved in the selective transport and maturation of TGF- alpha family proteins; Belongs to the cornichon family. | 0.483 |
RNF170 | CGRRF1 | ENSP00000445725 | ENSP00000216420 | E3 ubiquitin-protein ligase RNF170; E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. | Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines. | 0.516 |