node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CLCC1 | COX10 | ENSP00000349456 | ENSP00000261643 | Chloride channel CLIC-like protein 1; Seems to act as a chloride ion channel. Plays a role in retina development. Belongs to the chloride channel MCLC family. | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the UbiA prenyltransferase family. | 0.611 |
CLCC1 | COX11 | ENSP00000349456 | ENSP00000299335 | Chloride channel CLIC-like protein 1; Seems to act as a chloride ion channel. Plays a role in retina development. Belongs to the chloride channel MCLC family. | Cytochrome c oxidase assembly protein COX11, mitochondrial; Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. | 0.832 |
CLCC1 | COX15 | ENSP00000349456 | ENSP00000016171 | Chloride channel CLIC-like protein 1; Seems to act as a chloride ion channel. Plays a role in retina development. Belongs to the chloride channel MCLC family. | Cytochrome c oxidase assembly protein COX15 homolog; May be involved in the biosynthesis of heme A. Belongs to the COX15/CtaA family. | 0.821 |
CLCC1 | MT-CO1 | ENSP00000349456 | ENSP00000354499 | Chloride channel CLIC-like protein 1; Seems to act as a chloride ion channel. Plays a role in retina development. Belongs to the chloride channel MCLC family. | Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] | 0.604 |
CLCC1 | PIGBOS1 | ENSP00000349456 | ENSP00000484893 | Chloride channel CLIC-like protein 1; Seems to act as a chloride ion channel. Plays a role in retina development. Belongs to the chloride channel MCLC family. | Protein PIGBOS1; Plays a role in regulation of the unfolded protein response triggered by endoplasmic reticulum (ER) stress resulting from the presence of unfolded proteins in the ER lumen. | 0.545 |
CLCC1 | SCO1 | ENSP00000349456 | ENSP00000255390 | Chloride channel CLIC-like protein 1; Seems to act as a chloride ion channel. Plays a role in retina development. Belongs to the chloride channel MCLC family. | Protein SCO1 homolog, mitochondrial; Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Not required for the synthesis of MT-CO2/COX2 but plays a crucial role in stabilizing MT- CO2/COX2 during its subsequent maturation. Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1 (By similarity). Belongs to the SCO1/2 family. | 0.562 |
CLCC1 | SPNS3 | ENSP00000349456 | ENSP00000347721 | Chloride channel CLIC-like protein 1; Seems to act as a chloride ion channel. Plays a role in retina development. Belongs to the chloride channel MCLC family. | Protein spinster homolog 3; Sphingolipid transporter. | 0.599 |
CLCC1 | THYN1 | ENSP00000349456 | ENSP00000341657 | Chloride channel CLIC-like protein 1; Seems to act as a chloride ion channel. Plays a role in retina development. Belongs to the chloride channel MCLC family. | Thymocyte nuclear protein 1; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. | 0.580 |
CLCC1 | UQCRFS1 | ENSP00000349456 | ENSP00000306397 | Chloride channel CLIC-like protein 1; Seems to act as a chloride ion channel. Plays a role in retina development. Belongs to the chloride channel MCLC family. | Cytochrome b-c1 complex subunit Rieske, mitochondrial; [Cytochrome b-c1 complex subunit Rieske, mitochondrial]: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b- c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and su [...] | 0.821 |
CLCC1 | VPS39 | ENSP00000349456 | ENSP00000335193 | Chloride channel CLIC-like protein 1; Seems to act as a chloride ion channel. Plays a role in retina development. Belongs to the chloride channel MCLC family. | Vam6/Vps39-like protein; Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2- dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation. | 0.553 |
COX10 | CLCC1 | ENSP00000261643 | ENSP00000349456 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the UbiA prenyltransferase family. | Chloride channel CLIC-like protein 1; Seems to act as a chloride ion channel. Plays a role in retina development. Belongs to the chloride channel MCLC family. | 0.611 |
COX10 | COX11 | ENSP00000261643 | ENSP00000299335 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the UbiA prenyltransferase family. | Cytochrome c oxidase assembly protein COX11, mitochondrial; Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. | 0.982 |
COX10 | COX15 | ENSP00000261643 | ENSP00000016171 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the UbiA prenyltransferase family. | Cytochrome c oxidase assembly protein COX15 homolog; May be involved in the biosynthesis of heme A. Belongs to the COX15/CtaA family. | 0.999 |
COX10 | MT-CO1 | ENSP00000261643 | ENSP00000354499 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the UbiA prenyltransferase family. | Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] | 0.996 |
COX10 | SCO1 | ENSP00000261643 | ENSP00000255390 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the UbiA prenyltransferase family. | Protein SCO1 homolog, mitochondrial; Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Not required for the synthesis of MT-CO2/COX2 but plays a crucial role in stabilizing MT- CO2/COX2 during its subsequent maturation. Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1 (By similarity). Belongs to the SCO1/2 family. | 0.964 |
COX10 | UQCRFS1 | ENSP00000261643 | ENSP00000306397 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the UbiA prenyltransferase family. | Cytochrome b-c1 complex subunit Rieske, mitochondrial; [Cytochrome b-c1 complex subunit Rieske, mitochondrial]: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b- c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and su [...] | 0.857 |
COX11 | CLCC1 | ENSP00000299335 | ENSP00000349456 | Cytochrome c oxidase assembly protein COX11, mitochondrial; Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. | Chloride channel CLIC-like protein 1; Seems to act as a chloride ion channel. Plays a role in retina development. Belongs to the chloride channel MCLC family. | 0.832 |
COX11 | COX10 | ENSP00000299335 | ENSP00000261643 | Cytochrome c oxidase assembly protein COX11, mitochondrial; Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the UbiA prenyltransferase family. | 0.982 |
COX11 | COX15 | ENSP00000299335 | ENSP00000016171 | Cytochrome c oxidase assembly protein COX11, mitochondrial; Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. | Cytochrome c oxidase assembly protein COX15 homolog; May be involved in the biosynthesis of heme A. Belongs to the COX15/CtaA family. | 0.931 |
COX11 | MT-CO1 | ENSP00000299335 | ENSP00000354499 | Cytochrome c oxidase assembly protein COX11, mitochondrial; Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. | Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] | 0.964 |