STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CLDND2Claudin domain containing 2. (167 aa)    
Predicted Functional Partners:
MISP3
Uncharacterized protein MISP3; MISP family member 3; Belongs to the MISP family.
   
  
 0.600
LIM2
Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family.
  
  
 0.517
TTC38
Tetratricopeptide repeat domain 38; Belongs to the TTC38 family.
   
  
 0.508
BPIFA3
BPI fold containing family A member 3; Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
   
  
 0.496
CCDC102A
Coiled-coil domain containing 102A.
   
  
 0.454
C12orf73
Uncharacterized protein C12orf73; Chromosome 12 open reading frame 73.
      
 0.437
ANKRD39
Ankyrin repeat domain 39; Belongs to the ANKRD39 family.
   
  
 0.436
PPP1R32
Protein phosphatase 1 regulatory subunit 32.
   
  
 0.434
BPIFA2
BPI fold-containing family A member 2; Has strong antibacterial activity against P. aeruginosa. Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
      
 0.415
BPIFB4
BPI fold-containing family B member 4; May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity); Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
   
  
 0.404
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.