node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CEACAM19 | CLPTM1 | ENSP00000384887 | ENSP00000336994 | CEA cell adhesion molecule 19; Belongs to the immunoglobulin superfamily. CEA family. | Cleft lip and palate transmembrane protein 1; May play a role in T-cell development; Belongs to the CLPTM1 family. | 0.510 |
CLPTM1 | CEACAM19 | ENSP00000336994 | ENSP00000384887 | Cleft lip and palate transmembrane protein 1; May play a role in T-cell development; Belongs to the CLPTM1 family. | CEA cell adhesion molecule 19; Belongs to the immunoglobulin superfamily. CEA family. | 0.510 |
CLPTM1 | GLG1 | ENSP00000336994 | ENSP00000205061 | Cleft lip and palate transmembrane protein 1; May play a role in T-cell development; Belongs to the CLPTM1 family. | Golgi apparatus protein 1; Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils). | 0.524 |
CLPTM1 | HM13 | ENSP00000336994 | ENSP00000381237 | Cleft lip and palate transmembrane protein 1; May play a role in T-cell development; Belongs to the CLPTM1 family. | Minor histocompatibility antigen H13; Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Cleav [...] | 0.546 |
CLPTM1 | HTRA1 | ENSP00000336994 | ENSP00000357980 | Cleft lip and palate transmembrane protein 1; May play a role in T-cell development; Belongs to the CLPTM1 family. | Serine protease HTRA1; Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF- binding proteins. Inhibits sign [...] | 0.549 |
CLPTM1 | ITM2C | ENSP00000336994 | ENSP00000322730 | Cleft lip and palate transmembrane protein 1; May play a role in T-cell development; Belongs to the CLPTM1 family. | Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). | 0.620 |
CLPTM1 | MAD1L1 | ENSP00000336994 | ENSP00000385334 | Cleft lip and palate transmembrane protein 1; May play a role in T-cell development; Belongs to the CLPTM1 family. | Mitotic spindle assembly checkpoint protein MAD1; Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding. | 0.526 |
CLPTM1 | MAD2L1 | ENSP00000336994 | ENSP00000296509 | Cleft lip and palate transmembrane protein 1; May play a role in T-cell development; Belongs to the CLPTM1 family. | Mitotic spindle assembly checkpoint protein MAD2A; Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate. | 0.488 |
CLPTM1 | MTSS1 | ENSP00000336994 | ENSP00000322804 | Cleft lip and palate transmembrane protein 1; May play a role in T-cell development; Belongs to the CLPTM1 family. | Protein MTSS 1; May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton. | 0.553 |
CLPTM1 | UBAC2 | ENSP00000336994 | ENSP00000383911 | Cleft lip and palate transmembrane protein 1; May play a role in T-cell development; Belongs to the CLPTM1 family. | Ubiquitin-associated domain-containing protein 2; Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets. In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin- mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6. | 0.528 |
CLPTM1 | VAC14 | ENSP00000336994 | ENSP00000261776 | Cleft lip and palate transmembrane protein 1; May play a role in T-cell development; Belongs to the CLPTM1 family. | Protein VAC14 homolog; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. | 0.446 |
GLG1 | CLPTM1 | ENSP00000205061 | ENSP00000336994 | Golgi apparatus protein 1; Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils). | Cleft lip and palate transmembrane protein 1; May play a role in T-cell development; Belongs to the CLPTM1 family. | 0.524 |
HM13 | CLPTM1 | ENSP00000381237 | ENSP00000336994 | Minor histocompatibility antigen H13; Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Cleav [...] | Cleft lip and palate transmembrane protein 1; May play a role in T-cell development; Belongs to the CLPTM1 family. | 0.546 |
HM13 | UBAC2 | ENSP00000381237 | ENSP00000383911 | Minor histocompatibility antigen H13; Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Cleav [...] | Ubiquitin-associated domain-containing protein 2; Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets. In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin- mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6. | 0.594 |
HTRA1 | CLPTM1 | ENSP00000357980 | ENSP00000336994 | Serine protease HTRA1; Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF- binding proteins. Inhibits sign [...] | Cleft lip and palate transmembrane protein 1; May play a role in T-cell development; Belongs to the CLPTM1 family. | 0.549 |
HTRA1 | MTSS1 | ENSP00000357980 | ENSP00000322804 | Serine protease HTRA1; Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF- binding proteins. Inhibits sign [...] | Protein MTSS 1; May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton. | 0.496 |
ITM2C | CLPTM1 | ENSP00000322730 | ENSP00000336994 | Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). | Cleft lip and palate transmembrane protein 1; May play a role in T-cell development; Belongs to the CLPTM1 family. | 0.620 |
MAD1L1 | CLPTM1 | ENSP00000385334 | ENSP00000336994 | Mitotic spindle assembly checkpoint protein MAD1; Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding. | Cleft lip and palate transmembrane protein 1; May play a role in T-cell development; Belongs to the CLPTM1 family. | 0.526 |
MAD1L1 | MAD2L1 | ENSP00000385334 | ENSP00000296509 | Mitotic spindle assembly checkpoint protein MAD1; Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding. | Mitotic spindle assembly checkpoint protein MAD2A; Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate. | 0.999 |
MAD2L1 | CLPTM1 | ENSP00000296509 | ENSP00000336994 | Mitotic spindle assembly checkpoint protein MAD2A; Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate. | Cleft lip and palate transmembrane protein 1; May play a role in T-cell development; Belongs to the CLPTM1 family. | 0.488 |